Abstract
Purpose
Due to substantial increase in obesity, the demand for total knee arthroplasty (TKA) in obese and morbidly obese patients is higher than ever. This review aims to investigate mid- to long-term complications, revision rates, and outcome for morbidly obese, compared with non-obese after TKA.
Methods
A systematic search was conducted in May 2021. Included studies reported revision rates for morbidly obese and non-obese with a mean follow-up of at least 2 years. Reported knee society score (KSS) has been used to compare the functional outcome. PRISMA protocol was followed, and PROSPERO registered (ID: CRD42021254119).
Results
From 12 studies that met the inclusion criteria, a total of 1031 cases of morbidly obese and 9797 cases of non-obese controls were included. The risk ratio for revision was 1.48 for the morbidly obese, compared with non-obese (95% CI: 0.98 to 2.24; P = 0.06). Regarding aseptic and septic revision, the risk ratio was 1.44 (95% CI: 0.64 to 3.25; P = 0.37) and 2.22 (95% CI: 0.89 to 5.57; P = 0.09), respectively. The morbidly obese scored lower in Objective Knee Society Score (OKSS) and Functional Knee Society Score (FKSS) both preoperatively and postoperatively, compared with the non-obese; however, the two groups improved equally in function scores OKSS (P= 0.967) and FKSS (P = 0.834). Overall risk ratio for complications was 1.56 (95% CI: 0.98 to 2.48; P = 0.06).
Conclusions
The gained benefit in functional outcome surpasses the increase in risk of revision and complications for the morbidly obese in TKA surgery.
Introduction
Total knee arthroplasty (TKA) is a safe, popular, and reliable surgical treatment of pain and disability from degenerative knee arthrosis. Obesity is a growing problem worldwide, and WHO reports that rates of obesity continue to grow and that 650 million people were found obese in 2016 (1). BMI has increased 0.4 and 0.5 kg/m2 each decade for men and women, respectively, from 1980 to 2008 (2). Normal weight is defined as 18.5–24.9 kg/m2, overweight: 25–29.9 kg/m2, obesity: ≥ 30 kg/m2, and obesity class III, which this study will be investigating, ≥ 40 kg/m2 (3). Obesity class III is also known as morbidly obese. A consequence of obesity is a greater load on weight-bearing joints. Obesity correlates to osteoarthritis (OA) and is known to disproportionally increase and accelerate knee arthrosis (4, 5, 6, 7). Aging as well is correlated with OA (8, 9, 10), and since the world’s population is getting older, this further increases the demand for arthroplasty independently of obesity. Although there is a high demand for TKA in obese and morbidly obese at present, the demand is expected to increase even further in the future (11).
Several studies have found increased short-term complications in obese and morbidly obese patients after TKA (12, 13, 14, 15, 16). Studies investigating mid- to long-term complications and outcome in morbidly obese have been more ambiguous due to smaller sample sizes and low event rates (7). One review has found an increased long-term revision rate in morbidly obese (17), another only found increased septic revision (18), and a third failed to conclude anything with certainty (19). This review aims to investigate mid- to long-term complications and outcome for morbidly obese, compared with non-obese after TKA – taken the latest studies in the field into consideration. The outcome will be measured as revision rate and functional outcome. Reported complications will be compared.
Methods
Search strategy
This review was conducted in accordance with Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) (20, 21) and registered on PROSPERO (ID: CRD42021254119). A systematic search was conducted in May 2021 in relevant databases (PubMed and Embase from 1985 to May 2021). To correctly identify the relevant studies, the terminologies total knee replacement as well as total knee arthroplasty were used. In order to conduct one united search where all suffixes of the words obese and morbid are included, the symbol ‘*’ has been used as a part of the search.
The following search string has been used: ‘(total knee replacement OR total knee arthroplasty) AND morbid* obes*’. A total of 555 results were found, 282 results from PubMed and 273 results from Embase. After the removal of 175 duplicates, the 380 remaining results were screened (Fig. 1).
Flowchart of identification, screening, eligibility, and inclusion of studies.
Citation: EFORT Open Reviews 7, 5; 10.1530/EOR-21-0090
Eligibility criteria
To clearly investigate the difference in complications and the outcome for morbidly obese, compared with non-obese after TKA, the following inclusion criteria were chosen: The studies must report revision rate for morbidly obese (BMI: ≥ 40 kg/m2) and non-obese (BMI: ≤ 30 kg/m2) after TKA. Studies comparing morbidly obese with normal weight (BMI: 18.5–25 kg/m2) will also be included. Only studies with a mean of at least 2 years of follow-up were included. Studies must be published in English. JT has screened the 380 studies found in the search and screened relevant reference lists for additional inclusion. If possible, eligibility could not be determined by title or abstract screening, full articles were assessed. Before final inclusion, full article texts were assessed against eligibility criteria by MA and JT together to confirm consensus on final inclusion.
Risk of bias assessment
All included studies are retrospective, there were no available RCTs which met the eligibility criteria, and we, therefore, did not find risk and bias regarding allocation or blinding. The risk of selection bias was not considered significant as all studies included reported all cases operated within a given time frame selected by their BMI grouping. Only studies reporting revision rates have been included. The exclusion of studies omitting revision rates have been chosen to reduce the potential risk of reporting bias.
Data items
Data from the included studies have been extracted into a data sheet. If a study has multiple BMI groups within the inclusion criteria, the groups have been merged into one single group. Several studies reported revision rate and complications in percentage and not in actual events. To create a forest plot, percentages have been calculated back to actual events. When necessary, means and range will be approximated from the figures in the report. Data extracted are the following: number of patients and TKAs, revision rates, BMI, patients’ mean age, follow-up time, pre- and postoperative objective and functional Knee Society Scores, overall complications rate, prosthetic loosening, superficial wound infection, and thromboembolic events. Other data regarding complications will be extracted if considered important.
Statistical analysis
The risk ratios for revision have been quantitatively pooled using a random effect model. The results were reported using a forest plot, including individual and pooled point estimates along with 95% CIs. Heterogeneity was calculated using the I2 statistic.
A Welch t-test has been used to compare Knee Society Score improvements. To compare Knee Society Score preoperative and postoperative a paired t-test has been used. Data analysis was performed using RevMan 5.4 (Cochrane Collaboration) and R 3.6.1. Significance was defined as P ≤ 0.05.
Results
Search results
In this study, 555 results were identified on PubMed and Embase, in which 175 results were duplicates. All remaining titles were screened of which 155 studies were further assessed for abstract or full article. Ten passed the inclusion criteria. In total, 74 studies from reference lists were screened and assessed for eligibility. From these, two further studies were included. The flowchart of identification to inclusion is presented in Fig. 1. In total, 12 studies were included in this review (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33).
Cohort demographics
Studies from 1996 to 2019 matched the reviews criteria. The BMI range of the morbidly obese group is from 40 to 68.2 kg/m2, compared with 18 to 30 kg/m2 in the non-obese group. A total of 1031 TKAs were performed in the morbidly obese group and 9797 were performed in the non-obese group. Hakim et al. (25) and Bordini et al. (32) did not report age differences between their BMI groups but reported the mean age of all patients to be 64.3 years (48–83 years) and 72 years (71.8–72.1), respectively. Both studies claim no age differences to be seen in the two groups. When comparing the other 10 studies, the morbidly obese group is an average of 6.7 years younger than patients in the non-obese group. In Table 1, the reported BMI and patient-age of each study are shown. All studies have a mean follow-up of at least 2 years, with a range of 0.5–17 years. Seven out of the 12 studies reported mean follow-up for both groups. When comparing these seven studies, an overall of 0.5 years in follow-up difference between the two groups is found. Dewan et al. (27) had the biggest follow-up difference, 2 years of difference between the two groups. The six other studies showed a range of 0–0.5 years of follow-up difference. Bordini et al. (32) only reported mean follow-up for all patients (3.1 years). Naziri et al. (22) did not give any mean follow-up independently for the two groups but reported that patients were matched within 4 months. Hakim et al. (25) had a follow-up period with a mean of 10.8 years (4–17 years) and reported no difference in follow-up between the two groups. All follow-up information is presented in Table 2.
Demographic information of the included studies. Showing year of publication, mean BMI in kg/m2 in the morbidly obese and non-obese group, and mean age in years in the morbidly obese and non-obese group.
| Study | Year | Mean BMI (range) | Mean age (range) | ||
|---|---|---|---|---|---|
| Morbidly obese | Non-obese | Morbidly obese | Non-obese | ||
| Amin et al. (29) | 2006 | 43 (40–61) | 27 (23–30) | 62 (40–80) | 63 (42–80) |
| Bordini et al. (32) | 2009 | NR (>40) | NR (<30) | NR (NR) | NR (NR) |
| Chen et al. (28) | 2016 | NR (>40) | NR (<25) | 61 (NR) | 68 (NR) |
| Dewan et al. (27) | 2009 | 44 (>40) | 25 (20–29) | 58 (NR) | 66 (NR) |
| Ersozlu et al. (26) | 2007 | 42 (40–45) | 27 (24–30) | 60 (NR) | 67 (NR) |
| Foran et al. (33) | 2004 | 43 (40–47) | 26 (18–30) | 65 (32–84) | 70 (42–84) |
| Hakim et al. (25) | 2019 | 46 (40–68.2) | NR (21–29.99) | NR (NR) | NR (NR) |
| Krushell et al. (24) | 2007 | 44 (40–53) | 26 (20–29) | 67 (48–81) | 69 (39–82) |
| Mont et al. (31) | 1996 | NR (>40) | NR (<30) | 61 (30-70) | 58 (30-76) |
| Naziri et al. (22) | 2013 | 54 (50–66) | 28 (25–30) | 60 (43–74) | 59 (45–75) |
| Ponnusamy et al. (30) | 2018 | 47 (NR) | 25 (NR) | 61 (NR) | 70 (NR) |
| Spicer et al. (23) | 2001 | NR (>40) | NR (<30) | 63 (41–78) | 70 (35–83) |
NR, not reported.
Number of cases and mean follow-up in the morbidly obese groups (MO) and non-obese groups (NO) from all the studies. Follow-up and range are reported in years, revision rate in %. P value presents a revision rate difference between the two BMI groups.
| Study | Year | Patients (knees) | Follow-up, years (range) | Revision, % | P value | |||
|---|---|---|---|---|---|---|---|---|
| MO | NO | MO | NO | MO | NO | |||
| Amin et al. (29) | 2006 | 38 (41) | 38 (41) | 3.2 (0.5–5.5) | 3.7 (0.5–5.6) | 26 | 0 | 0.01 |
| Bordini et al. (32) | 2009 | NR (172) | NR (6532) | NR (1.5–6) | NR (1.5–6) | 2 | 2 | NR |
| Chen et al. (28) | 2016 | 117 (117) | 2108 (2108) | NR (2-10) | NR (2-10) | 2 | 1 | 0.703 |
| Dewan et al. (27) | 2009 | 31 (41) | 67 (85) | 4 (NR) | 6 (NR) | 7 | 5 | 0.816 |
| Ersozlu et al. (26) | 2007 | 21 (42) | 20 (40) | 2.7 (2–3.3) | 2.7 (2–3.3) | 0 | 0 | NR |
| Foran et al. (33) | 2004 | 11 (12) | 68 (78) | 6.6 (5–8.9) | 6.9 (5–10.3) | 8 | 0 | 0.02 |
| Hakim et al. (25) | 2019 | 127 (162) | 37 (38) | 10.1 (4–NR) | NR (4–NR) | 2 | 3 | NR |
| Krushell et al. (24) | 2007 | NR (39) | NR (39) | 7.5 (5.2–14.1) | 7.5 (5–13.2) | 5 | 0 | NR |
| Mont et al. (31) | 1996 | 45 (50) | 45 (50) | 5.4 (2–12) | 5.2 (2–11.3) | 8 | 4 | NR |
| Naziri et al. (22) | 2013 | 95 (101) | 95 (101) | 5.2 (3–7.1) | NR | 7 | 3 | 0.28 |
| Ponnusamy et al. (30) | 2018 | 195 (195) | 260 (260) | NR (3–NR) | NR (3–NR) | 7 | 7 | NR |
| Spicer et al. (23) | 2001 | NR (59) | 371 (425) | 6.1 (4–12) | 6.3 (4–12) | 5 | 3 | NR |
NR, not reported.
Outcome
Revision rates
Two studies reported significantly higher revision rates for morbid obese, compared with non-obese (29, 33). Amin et al. (29) found the biggest difference between the two groups, 26% morbidly obese revisions, compared with 0% (P = 0.01) in non-obese. Three studies did not find significant difference (22, 27, 28). The rest of the studies did not report statistical testing of the difference between the groups. Table 2 presents all revision rates reported. All together the morbidly obese group had a mean revision rate of 6.6%, compared with 2.3% in the non-obese group. A forest plot of overall revision rates is presented in Fig. 2. The risk ratio for revision is 1.48 for the morbidly obese, compared with the non-obese (95% CI: 0.98 to 2.24; P = 0.06). The 95% CIs from all studies overlap which suggest low heterogeneity. The I 2 equals 2%, this likewise indicate homogeneity across all studies. Due to the high number of patients in both groups and the narrow CI, Ponnusamy et al. (30) weighted highest, 34.7%. Ponnusamy et al. (30) did not find a higher revision rate for morbidly obese patients. However, their super obese subgroup (BMI: 50+ kg/m2) had significantly higher septic revisions than all the other subgroups with BMI less than 40 kg/m2 (P = 0.03).
Forest plot of risk ratios for revision among TKA performed in morbidly obese and non-obese patients. Events refer to the number of revisions for each group, and the total indicates the number of knees operated in each group. M–H, Mantel–Haenszel; df, degrees of freedom.
Citation: EFORT Open Reviews 7, 5; 10.1530/EOR-21-0090
Six studies reported aseptic revision (22, 24, 25, 29, 30, 32), and seven studies reported septic revision (22, 24, 25, 26, 29, 30, 32). The risk ratio for aseptic revision is 1.44 for morbidly obese, compared with non-obese (95% CI: 0.64 to 3.25; P = 0.37), and the risk ratio for septic revision is 2.22 for morbidly obese, compared with non-obese (95% CI: 0.89 to 5.57; P = 0.09). Forest plots of aseptic and septic revisions is shown in Figs 3 and 4.
Forest plot of risk ratios for aseptic revision among TKA performed in morbidly obese and non-obese patients. Events refer to the number of aseptic revisions for each group, and total indicates the number of knees operated in each group. M–H, Mantel–Haenszel; df, degrees of freedom.
Citation: EFORT Open Reviews 7, 5; 10.1530/EOR-21-0090
Forest plot of risk ratios for septic revision TKA performed in morbidly obese and non-obese patients. Events refer to the number of septic revisions for each group, and total indicates the number of knees operated in each group. M–H, Mantel–Haenszel; df, degrees of freedom.
Citation: EFORT Open Reviews 7, 5; 10.1530/EOR-21-0090
Knee Society Scores
Ten of the studies report Objective Knee Society Score (OKSS) and eight of the studies report Functional Knee Society Score (FKSS) (Table 3). The morbidly obese group and the non-obese group scored significantly higher in OKSS and FKSS at follow-up, compared with before TKA (P < 0.001). The morbidly obese improved from a mean of 43 (range: 0–78) to 87 (range: 32–100) in OKSS, compared with a mean of 46 (range: 0–83) to 90 (range: 45–100) in the non-obese group. In FKSS, the morbidly obese scored a mean of 40 (range: 0–85) preoperative and improved to 68 (range: 0–100) postoperative, compared with 46 (range: 0–97) to 76 (range: 20–100) in the non-obese group. The morbidly obese improved a mean of 47.3 in OKSS, compared to 47.0 in the non-obese group (P = 0.967). In FKSS, the morbidly obese improved a mean of 29.4, compared to 30.4 in the non-obese group (P = 0.834).
Objective and Functional Knee Society Score (OKSS and FKSS) for morbidly obese (MO) and non-obese (NO). Pre- and post-operative scores as well as improvement values are mean.
| Study | Year | Preoperative (range) | Postoperative (range) | Improvement | |||
|---|---|---|---|---|---|---|---|
| MO | NO | MO | NO | MO | NO | ||
| Objective Knee Society Score | |||||||
| Amin et al. (29) | 2006 | 28 (0–57) | 30 (0–56) | 86 (32–97) | 91 (45–100) | 58 | 61 |
| Chen et al. (28) | 2016 | 33 (NR) | 40 (NR) | 83 (NR) | 85 (NR) | 50 | 45 |
| Dewan et al. (27) | 2009 | 53 (NR) | 55 (NR) | 85 (NR) | 89 (NR) | 32 | 34 |
| Ersozlu et al. (26) | 2007 | 61 (42–76) | 70 (61–83) | 87 (57–94) | 91 (64–97) | 26 | 21 |
| Hakim et al. (25) | 2019 | 46 (NR) | 43 (NR) | 84 (NR) | 86 (NR) | 38 | 42 |
| Krushell et al. (24) | 2007 | 30 (14–65) | 34 (13–70) | 91 (50–100) | 94 (50–100) | 61 | 60 |
| Mont et al. (31) | 1996 | 42 (30–52) | NR (NR) | 88 (50–100) | 91 (NR) | 46 | NR |
| Naziri et al. (22) | 2013 | 53 (23–78) | 50 (35–69) | 91 (58–100) | 94 (66–100) | 42 | 44 |
| Ponnusamy et al. (30) | 2018 | NR (NR) | NR (NR) | NR (NR) | NR (NR) | 79 | 73 |
| Spicer et al. (23) | 2001 | 45 (NR) | 48 (NR) | 86 (NR) | 91 (NR) | 41 | 43 |
| Functional Knee Society Score | |||||||
| Amin et al. (29) | 2006 | 51 (0–75) | 52 (10–80) | 76 (30–100) | 83 (35–100) | 25 | 31 |
| Chen et al. (28) | 2016 | 39 (NR) | 53 (NR) | 58 (NR) | 74 (NR) | 20 | 21 |
| Dewan et al. (27) | 2009 | 42 (NR) | 46 (NR) | 68 (NR) | 66 (NR) | 26 | 20 |
| Ersozlu et al. (26) | 2007 | 46 (39–74) | 56 (64–97) | 80 (55–83) | 86 (60–100) | 46 | 30 |
| Hakim et al. (25) | 2019 | 37 (NR) | 39 (NR) | 72 (NR) | 80 (NR) | 35 | 41 |
| Krushell et al. (24) | 2007 | 31 (0–50) | 38 (0–80) | 44 (0–90) | 64 (20–100) | 13 | 26 |
| Naziri et al. (22) | 2013 | 52 (0–85) | 54 (35–70) | 82 (30–100) | 90 (64–100) | 30 | 36 |
| Spicer et al. (23) | 2001 | 20 (NR) | 30 (NR) | 60 (NR) | 68 (NR) | 40 | 38 |
NR, not reported.
Complications
Out of the included studies, six reported more frequent complication rates in the morbidly obese (22, 24, 27, 28, 29, 31). In four studies, the complication rates are fairly close (25, 26, 30, 32). Two studies did not report complications (23, 33). Six studies reported overall complication rate (22, 25, 26, 27, 29, 32), and six studies reported superficial wound infection rate (22, 25, 26, 29, 30, 31). Overall complication rate was 19.5% in the morbidly obese, compared with 10.0% in the non-obese. The risk ratio for overall complications for morbidly obese, compared with non-obese was 1.56 (95% CI: 0.98 to 2.48; P = 0.06) (Fig. 5). When comparing superficial wound infection rates an increased rate was seen in the morbidly obese with a mean of 7.2%, compared with 1.8% in the non-obese. The risk ratio for superficial wound infection was 2.32 for morbidly obese, compared with non-obese (95% CI: 1.30 to 4.13; P = 0.005) (Fig. 6). The largest reported difference between the two groups was in Amin et al. (29), with 32% overall complications in morbidly obese, compared with 0% in the non-obese group. Conversely, Hakim et al. (25) found a 10.5% overall complication rate in the non-obese, compared with 9.9% in the morbidly obese. However, the non-obese group had only 38 subjects and the study did show significantly higher overall complication rate in the morbidly obese, compared to their obese subgroup (BMI: 30–40 kg/m2). Mont et al. (31) reported 12% of wound healing problems for morbidly obese, compared with 2% in non-obese. However, they did not find significant difference in final outcome between the morbidly obese and the non-obese groups (P = 0.7). Other complications found in the included studies are presented in Table 4.
Forest plot of risk ratio for overall complications in morbidly obese compared with non-obese patients. Events refer to the number of complications in each group, and total indicates the number of knees operated in each group. M–H, Mantel–Haenszel; df, degrees of freedom.
Citation: EFORT Open Reviews 7, 5; 10.1530/EOR-21-0090
Forest plot of risk ratio for superficial wound infection in morbidly obese compared with non-obese patients. Events refer to the number of superficial wound infections in each group, and total indicates the number of knees operated in each group. M–H, Mantel–Haenszel; df, degrees of freedom.
Citation: EFORT Open Reviews 7, 5; 10.1530/EOR-21-0090
Complications found in all studies.
| Study | Year | Morbidly obese | Non-obese |
|---|---|---|---|
| Amin et al. (29) | 2006 | Overall complication rate: 32% | Overall complication rate: 0% |
| Superficial wound infection: 17% | Superficial wound infection: 0% | ||
| Radiographic loosening: 4.9% | Radiographic loosening: 0% | ||
| Bordini et al. (32) | 2009 | Overall complication rate: 5.2% | Overall complication rate: 4.4% |
| Thromboembolic events: 0% | Thromboembolic events: 0.3% | ||
| Chen et al. (28) | 2016 | 30-day readmission: 6% | 30-day readmission: 3% |
| Dewan et al. (27) | 2009 | Overall complication rate: 26% | Overall complication rate: 15% |
| Infection 7% | Infection 4% | ||
| Ersozlu et al. (26) | 2007 | Overall complication rate: 30% | Overall complication rate: 25% |
| Superficial wound infection: 19% | Superficial wound infection: 5% | ||
| Foran et al. (33) | 2004 | NR | NR |
| Hakim et al. (25) | 2019 | Overall complication rate: 9.9% | Overall complication rate: 10.5% |
| Superficial wound infection: 2% | Superficial wound infection: 3% | ||
| Late deep infection: 0.6% | Late deep infection: 0% | ||
| Skin necrosis: 0.6% | Skin necrosis: 0% | ||
| Transient peronal palsy: 0.6% | Transient peronal palsy: 0.6% | ||
| Tromboembolic event: 1.9% | Tromboembolic event: 2.6% | ||
| Patellar clunk syndrome: 1.2% | Patellar clunk syndrome: 2.6% | ||
| Krushell et al. (24) | 2007 | Wound healing problems 20.5% | Wound healing problems 0% |
| Osteolysis or wear: 2.6% | Osteolysis or wear: 0% | ||
| Deep vein thrombosis: 2.6% | Deep vein thrombosis: 2.6% | ||
| Mont et al. (31) | 1996 | Superficial wound infection: 2% | Superficial wound infection: 0% |
| Wound healing problems 12% | Wound healing problems 2% | ||
| *Chronic knee pain: 8% | |||
| Naziri et al. (22) | 2013 | Overall complication rate: 14% | Overall complication rate: 5% |
| Superficial wound infection: 1% | Superficial wound infection: 0% | ||
| Wound healing problems 1% | Wound healing problems 0% | ||
| Ponnusamy et al. (30) | 2018 | Thromboembolic events: 0.5% | Thromboembolic events: 1.9% |
| Superficial wound infection: 9.2% | Superficial wound infection: 4.6% | ||
| 90 days readmission: 8.7% | 90 days readmission: 6.2% | ||
| Spicer et al. (23) | 2001 | NR | NR |
*4% had chronic pain prior to TKA.
NR, not reported.
Discussion
This review did not with certainty find morbidly obese to have an increased risk ratio for revision (P = 0.06). We found the true risk ratio for revision in morbidly obese, compared with non-obese after TKA to be between 0.98 to 2.24, with a certainty of 95%. The largest impact on our risk ratio for revision was reported by Ponnusamy et al., with a 34.7% weight. Ponnusamy et al. did not find any revision rate difference between the morbidly obese and non-obese groups. When calculating the risk ratio for revision excluding this study, a significant difference is found. Studies with a mean follow-up of at least 2 years were included in this review. Including studies with longer mean follow-up periods might better show a potential increased risk of revision in morbidly obese, however, few studies with longer follow-up periods exist. Only studies reporting revision rates have been included. The exclusion of studies omitting revision rates have been chosen to reduce the potential risk of reporting bias. Studies have suggested an increased risk of septic revision for morbidly obese (14, 18, 34, 35). When comparing studies with mid- to long-term follow-up, the risk ratio for septic revision is 2.22 for morbidly obese, compared with non-obese. However, a significant difference could not be found (P = 0.09). Nonetheless, this could indicate that morbidly obese have a higher risk ratio for septic revision than aseptic revision, 2.22 compared with 1.44 respectively. In this review, increased revision rate in morbidly obese cannot fully be confirmed. Increased aseptic loosening in morbidly obese has been attributed to higher degrees of mechanical stress (29, 36). Most morbidly obese have lower activity levels, and the overall mechanical stress might not be as big as earlier anticipated (37). Some studies have suggested the use of short-stemmed tibial components to help mitigate the risk of aseptic loosening (38, 39). Garceau et al. investigated this further and found significantly less tibial loosening when using short-stemmed tibial components in morbidly obese (40). They suggest that stemmed tibia may be considered in high-risk patients. In this study we did not find an increased risk of aseptic loosening in the morbidly obese using standard primary tibia components.
This review showed lower pre- and postoperative OKSS and FKSS in morbidly obese, compared with non-obese. However, the mean improvement was equivalent between the two groups. The objective and functional outcome such as pain relief, range of motion (ROM), knee alignment, knee stability, walking distance, and stair climbing vastly improve for the morbidly obese as well as for the non-obese. All patients regardless of BMI have great gain in functional outcome after TKA.
Ten out of 12 included studies reported mean age in their weight groups. All together the morbidly obese were a mean of 6.7 years younger than the non-obese. This indicates that morbidly obese are likely to develop severe arthrosis of the knee at an earlier age than non-obese, confirming the results of earlier studies (4, 5, 6, 7). Moreover, the age difference between the groups with almost 7 years younger average age in the morbidly obese group, means that this group is inherently more likely to fail earlier as young age itself is also an independent risk factor for early revision (41). If the morbidly obese and the non-obese groups had been stratified for age, more complications might have been found in the morbidly obese group.
A statistical analysis included all studies has not been possible because of the several different complications, which have been reported. However, most studies reported increased complication rates in morbidly obese. Six studies reported overall complications and the morbidly obese had a risk ratio of 1.56 for overall complications, compared with the non-obese (95% CI: 0.98 to 2.48; P = 0.06). Noticeably Amin et al. found an overall complication rate of 32% in the morbidly obese, compared with 0% in the non-obese (29). Comparing the six studies reporting superficial wound infection, a significantly increased risk ratio of 2.32 for morbidly obese, compared with non-obese was found (95% CI, 1.30 to 4.13; P = 0.005). Hakim et al. found significantly longer surgical incision length in morbidly obese patients, and suggest that this might be a co-factor for superficial infection (25). Other studies with a focus on perioperative and short-term complications in morbidly obese have likewise found a significant superficial infection rate (14, 24, 35, 42, 43), and also found an increased deep infection rate (14, 42). Prolonged operative times during TKA have been found to correlate with an increased infection rate (44, 45, 46). Operation time in obese is prolonged which partly could explain the increased infection rate. Another explanation could be a weakened immune response in obese. Krishnan et al. found significantly less macrophages matured from monocytes in obese individuals (47). In general, obese individuals have more comorbidities such as diabetes, which has shown significantly higher infection rates after arthroplasty (16).
It has been suggested that morbidly obese should optimize their condition prior to TKA (48, 49). However, studies investigating preoperative bariatric surgery have shown mixed results, and some studies have even reported the same or worse outcome (50, 51). A possible explanation for worse outcome in bariatric patients is concomitant malnutrition in this population (52). Patients may remain in catabolic state for 2 years after gastric bypass (53). Martin et al. investigated this in their review, and would neither encourage nor discourage preoperative bariatric surgery (54). Nelson et al. suggest that morbid obesity is not independently correlated with perioperative complications, and found a strong confound between low serum albumin levels and perioperative complications (55).
Conclusions
This review has found that morbidly obese have a 1.48 risk ratio for revision, compared with non-obese patients after TKA (95% CI: 0.98 to 2.24; P = 0.06). This could indicate that morbidly obese are more likely to need revision after TKA; however, the correlation between morbid obesity and revision rate may not be as high as earlier studies have concluded. A statistically significant risk of septic revision for morbidly obese, compared with non-obese, could not be found (P = 0.09). However, the risk ratio for septic revision in morbidly obese is 2.22, compared with a 1.44 risk ratio for aseptic revision. To better investigate the long-term revision rate, more studies with long-term follow-ups are needed. Morbidly obese patients in average scored lower OKSS and FKSS both prior and after TKA. However, they improve just as much in OKSS and FKSS as non-obese patients after TKA. The morbidly obese had increased risk of superficial wound infection with a risk ratio of 2.32 (95% CI: 1.30 to 4.13; P = 0.005) and a 1.56 risk ratio for overall complications (95% CI: 0.98 to 2.48; P = 0.06), compared with non-obese patients. We consider the gained benefit for the morbidly obese in functional outcome to surpass the risk in TKA. However, the morbidly obese patient should be encouraged to lose weight before TKA as well as after TKA.
ICMJE Conflict of Interest Statement
The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the work reported.
Funding Statement
This work did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector.
References
- 2.↑
Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y & Bahalim AN et al.National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet 2011 377 557–567. (https://doi.org/10.1016/S0140-6736(1062037-5)
- 3.↑
Weir CB, Jan A. BMI classification percentile and cut off points. In StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2021.
- 4.↑
Singer SP, Dammerer D, Krismer M, Liebensteiner MC. Maximum lifetime body mass index is the appropriate predictor of knee and hip osteoarthritis. Archives of Orthopaedic and Trauma Surgery 2018 138 99–103. (https://doi.org/10.1007/s00402-017-2825-5)
- 5.↑
Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK. Obesity and osteoarthritis in knee, hip and/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskeletal Disorders 2008 9 132. (https://doi.org/10.1186/1471-2474-9-132)
- 6.↑
Reijman M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, Bierma-Zeinstra SM. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Annals of the Rheumatic Diseases 2007 66 158–162. (https://doi.org/10.1136/ard.2006.053538)
- 7.↑
Kulkarni K, Karssiens T, Kumar V, Pandit H. Obesity and osteoarthritis. Maturitas 2016 89 22–28. (https://doi.org/10.1016/j.maturitas.2016.04.006)
- 8.↑
Shane Anderson A, Loeser RF. Why is osteoarthritis an age-related disease? Best Practice and Research: Clinical Rheumatology 2010 24 15–26. (https://doi.org/10.1016/j.berh.2009.08.006)
- 9.↑
Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, Goldring SR, Jones G, Teichtahl AJ, Pelletier JP. Osteoarthritis. Nature Reviews: Disease Primers 2016 2 16072. (https://doi.org/10.1038/nrdp.2016.72)
- 10.↑
Xia B, Di C, Zhang J, Hu S, Jin H, Tong P. Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcified Tissue International 2014 95 495–505. (https://doi.org/10.1007/s00223-014-9917-9)
- 11.↑
Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. Journal of Bone and Joint Surgery: American Volume 2007 89 780–785. (https://doi.org/10.2106/JBJS.F.00222)
- 12.↑
Friedman RJ, Hess S, Berkowitz SD, Homering M. Complication rates after hip or knee arthroplasty in morbidly obese patients. Clinical Orthopaedics and Related Research 2013 471 3358–3366. (https://doi.org/10.1007/s11999-013-3049-9)
- 13.↑
Schwarzkopf R, Thompson SL, Adwar SJ, Liublinska V, Slover JD. Postoperative complication rates in the ‘super-obese’ hip and knee arthroplasty population. Journal of Arthroplasty 2012 27 397–401. (https://doi.org/10.1016/j.arth.2011.04.017)
- 14.↑
Winiarsky R, Barth P, Lotke P. Total knee arthroplasty in morbidly obese patients. Journal of Bone and Joint Surgery: American Volume 1998 80 1770–1774. (https://doi.org/10.2106/00004623-199812000-00006)
- 15.↑
Mnatzaganian G, Ryan P, Norman PE, Davidson DC, Hiller JE. Use of routine hospital morbidity data together with weight and height of patients to predict in-hospital complications following total joint replacement. BMC Health Services Research 2012 12 380–. (https://doi.org/10.1186/1472-6963-12-380)
- 16.↑
Malinzak RA, Ritter MA, Berend ME, Meding JB, Olberding EM, Davis KE. Morbidly obese, diabetic, younger, and unilateral joint arthroplasty patients have elevated total joint arthroplasty infection rates. Journal of Arthroplasty 2009 24 (6 Supplement) 84–88. (https://doi.org/10.1016/j.arth.2009.05.016)
- 17.↑
Boyce L, Prasad A, Barrett M, Dawson-Bowling S, Millington S, Hanna SA, Achan P. The outcomes of total knee arthroplasty in morbidly obese patients: a systematic review of the literature. Archives of Orthopaedic and Trauma Surgery 2019 139 553–560. (https://doi.org/10.1007/s00402-019-03127-5)
- 18.↑
Chaudhry H, Ponnusamy K, Somerville L, McCalden RW, Marsh J, Vasarhelyi EM. Revision rates and functional outcomes among severely, morbidly, and super-obese patients following primary total knee arthroplasty: a systematic review and meta-analysis. JBJS Reviews 2019 7 e9. (https://doi.org/10.2106/JBJS.RVW.18.00184)
- 19.↑
Vaishya R, Vijay V, Wamae D, Agarwal AK. Is total knee replacement justified in the morbidly obese? A systematic review. Cureus 2016 8 e804. (https://doi.org/10.7759/cureus.804)
- 20.↑
Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA & PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews 2015 4 1. (https://doi.org/10.1186/2046-4053-4-1)
- 21.↑
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA & PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015 350 g7647. (https://doi.org/10.1136/bmj.g7647)
- 22.↑
Naziri Q, Issa K, Malkani AL, Bonutti PM, Harwin SF, Mont MA. Bariatric orthopaedics: total knee arthroplasty in super-obese patients (BMI > 50 kg/m2). Survivorship and complications. Clinical Orthopaedics and Related Research 2013 471 3523–3530. (https://doi.org/10.1007/s11999-013-3154-9)
- 23.↑
Spicer DD, Pomeroy DL, Badenhausen WE, Schaper Jr LA, Curry JI, Suthers KE, Smith MW. Body mass index as a predictor of outcome in total knee replacement. International Orthopaedics 2001 25 246–249. (https://doi.org/10.1007/s002640100255)
- 24.↑
Krushell RJ, Fingeroth RJ. Primary total knee arthroplasty in morbidly obese patients: a 5- to 14-year follow-up study. Journal of Arthroplasty 2007 22 (Supplement 2) 77–80. (https://doi.org/10.1016/j.arth.2007.03.024)
- 25.↑
Hakim J, Volpin G, Amashah M, Alkeesh F, Khamaisy S, Cohen M, Ownallah J. Long-term outcome of total knee arthroplasty in patients with morbid obesity. International Orthopaedics 2020 44 95–104. (https://doi.org/10.1007/s00264-019-04378-y)
- 26.↑
Ersozlu S, Akkaya T, Ozgur AF, Sahin O, Senturk I, Tandogan R. Bilateral staged total knee arthroplasty in obese patients. Archives of Orthopaedic and Trauma Surgery 2008 128 143–148. (https://doi.org/10.1007/s00402-007-0356-1)
- 27.↑
Dewan A, Bertolusso R, Karastinos A, Conditt M, Noble PC, Parsley BS. Implant durability and knee function after total knee arthroplasty in the morbidly obese patient. Journal of Arthroplasty 2009 24 89 .e3–94.e3. (https://doi.org/10.1016/j.arth.2009.04.024)
- 28.↑
Chen JY, Lo NN, Chong HC, Bin Abd Razak HR, Pang HN, Tay DK, Chia SL, Yeo SJ. The influence of body mass index on functional outcome and quality of life after total knee arthroplasty. Bone and Joint Journal 2016 98 - B 780–785. (https://doi.org/10.1302/0301-620X.98B6.35709)
- 29.↑
Amin AK, Clayton RA, Patton JT, Gaston M, Cook RE, Brenkel IJ. Total knee replacement in morbidly obese patients. Results of a prospective, matched study. Journal of Bone and Joint Surgery: British Volume 2006 88 1321–1326. (https://doi.org/10.1302/0301-620X.88B10.17697)
- 30.↑
Ponnusamy KE, Marsh JD, Somerville LE, McCalden RW, Vasarhelyi EM. Ninety-day costs, reoperations, and readmissions for primary total knee arthroplasty patients With varying body mass index levels. Journal of Arthroplasty 2018 33 S157–S161. (https://doi.org/10.1016/j.arth.2018.02.019)
- 31.↑
Mont MA, Mathur SK, Krackow KA, Loewy JW, Hungerford DS. Cementless total knee arthroplasty in obese patients. A comparison with a matched control group. Journal of Arthroplasty 1996 11 153–156. (https://doi.org/10.1016/s0883-5403(0580009-9)
- 32.↑
Bordini B, Stea S, Cremonini S, Viceconti M, De Palma R, Toni A. Relationship between obesity and early failure of total knee prostheses. BMC Musculoskeletal Disorders 2009 10 29. (https://doi.org/10.1186/1471-2474-10-29)
- 33.↑
Foran JRH, Mont MA, Etienne G, Jones LC, Hungerford DS. The outcome of total knee arthroplasty in obese patients. Journal of Bone and Joint Surgery: American Volume 2004 86 1609–1615. (https://doi.org/10.2106/00004623-200408000-00002)
- 34.↑
Werner BC, Evans CL, Carothers JT, Browne JA. Primary total knee arthroplasty in super-obese patients: dramatically higher postoperative complication rates even compared to revision surgery. Journal of Arthroplasty 2015 30 849–853. (https://doi.org/10.1016/j.arth.2014.12.016)
- 35.↑
Dowsey MM, Liew D, Stoney JD, Choong PF. The impact of pre-operative obesity on weight change and outcome in total knee replacement: a prospective study of 529 consecutive patients. Journal of Bone and Joint Surgery: British Volume 2010 92 513–520. (https://doi.org/10.1302/0301-620X.92B4.23174)
- 36.↑
Gunst S, Fessy MH. The effect of obesity on mechanical failure after total knee arthroplasty. Annals of Translational Medicine 2015 3 310. (https://doi.org/10.3978/j.issn.2305-5839.2015.10.37)
- 37.↑
McClung CD, Zahiri CA, Higa JK, Amstutz HC, Schmalzried TP. Relationship between body mass index and activity in hip or knee arthroplasty patients. Journal of Orthopaedic Research 2000 18 35–39. (https://doi.org/10.1002/jor.1100180106)
- 38.↑
Steere JT, Sobieraj MC, DeFrancesco CJ, Israelite CL, Nelson CL, Kamath AF. Prophylactic tibial stem fixation in the obese: comparative early results in primary total knee arthroplasty. Knee Surgery and Related Research 2018 30 227–233. (https://doi.org/10.5792/ksrr.18.022)
- 39.↑
Parratte S, Ollivier M, Lunebourg A, Verdier N, Argenson JN. Do stemmed tibial components in total knee arthroplasty improve outcomes in patients with obesity? Clinical Orthopaedics and Related Research 2017 475 137–145. (https://doi.org/10.1007/s11999-016-4791-6)
- 40.↑
Garceau SP, Harris NH, Felberbaum DL, Teo GM, Weinblatt AI, Long WJ. Reduced aseptic loosening with fully cemented short-stemmed tibial components in primary cemented total knee arthroplasty. Journal of Arthroplasty 2020 35 1591.e3–1594.e3. (https://doi.org/10.1016/j.arth.2020.01.084)
- 41.↑
Khan M, Osman K, Green G, Haddad FS. The epidemiology of failure in total knee arthroplasty: avoiding your next revision. Bone and Joint Journal 2016 98 - B (Supplement A) 105–112. (https://doi.org/10.1302/0301-620X.98B1.36293)
- 42.↑
Kerkhoffs GM, Servien E, Dunn W, Dahm D, Bramer JA, Haverkamp D. The influence of obesity on the complication rate and outcome of total knee arthroplasty: a meta-analysis and systematic literature review. Journal of Bone and Joint Surgery: American Volume 2012 94 1839–1844. (https://doi.org/10.2106/JBJS.K.00820)
- 43.↑
Ward DT, Metz LN, Horst PK, Kim HT, Kuo AC. Complications of morbid obesity in total joint arthroplasty: risk stratification based on BMI. Journal of Arthroplasty 2015 30 (9 Supplement) 42–46. (https://doi.org/10.1016/j.arth.2015.03.045)
- 44.↑
Peersman G, Laskin R, Davis J, Peterson MG, Richart T. Prolonged operative time correlates with increased infection rate after total knee arthroplasty. HSS Journal 2006 2 70–72. (https://doi.org/10.1007/s11420-005-0130-2)
- 45.↑
Gadinsky NE, Manuel JB, Lyman S, Westrich GH. Increased operating room time in patients with obesity during primary total knee arthroplasty: conflicts for scheduling. Journal of Arthroplasty 2012 27 1171–1176. (https://doi.org/10.1016/j.arth.2011.12.012)
- 46.↑
Duchman KR, Pugely AJ, Martin CT, Gao Y, Bedard NA, Callaghan JJ. Operative time affects short-term complications in total joint arthroplasty. Journal of Arthroplasty 2017 32 1285–1291. (https://doi.org/10.1016/j.arth.2016.12.003)
- 47.↑
Krishnan EC, Trost L, Aarons S, Jewell WR. Study of function and maturation of monocytes in morbidly obese individuals. Journal of Surgical Research 1982 33 89–97. (https://doi.org/10.1016/0022-4804(8290012-9)
- 48.↑
Wooten C, Curtin B. Morbid obesity and total joint replacement: is it okay to say no? Orthopedics 2016 39 207–209. (https://doi.org/10.3928/01477447-20160628-02)
- 49.↑
Keeney BJ, Austin DC, Jevsevar DS. Preoperative weight loss for morbidly obese patients undergoing total knee arthroplasty: determining the necessary amount. Journal of Bone and Joint Surgery: American Volume 2019 101 1440–1450. (https://doi.org/10.2106/JBJS.18.01136)
- 50.↑
Inacio MC, Paxton EW, Fisher D, Li RA, Barber TC, Singh JA. Bariatric surgery prior to total joint arthroplasty may not provide dramatic improvements in post-arthroplasty surgical outcomes. Journal of Arthroplasty 2014 29 1359–1364. (https://doi.org/10.1016/j.arth.2014.02.021)
- 51.↑
Severson EP, Singh JA, Browne JA, Trousdale RT, Sarr MG, Lewallen DG. Total knee arthroplasty in morbidly obese patients treated with bariatric surgery: a comparative study. Journal of Arthroplasty 2012 27 1696–1700. (https://doi.org/10.1016/j.arth.2012.03.005)
- 52.↑
Peterson LA, Cheskin LJ, Furtado M, Papas K, Schweitzer MA, Magnuson TH, Steele KE. Malnutrition in bariatric surgery candidates: multiple micronutrient deficiencies prior to surgery. Obesity Surgery 2016 26 833–838. (https://doi.org/10.1007/s11695-015-1844-y)
- 53.↑
Dalcanale L, Oliveira CP, Faintuch J, Nogueira MA, Rondó P, Lima VM, Mendonça S, Pajecki D, Mancini M, Carrilho FJ. Long-term nutritional outcome after gastric bypass. Obesity Surgery 2010 20 181–187. (https://doi.org/10.1007/s11695-009-9916-5)
- 54.↑
Martin JR, Jennings JM, Dennis DA. Morbid obesity and total knee arthroplasty: a growing problem. Journal of the American Academy of Orthopaedic Surgeons 2017 25 188–194. (https://doi.org/10.5435/JAAOS-D-15-00684)
- 55.↑
Nelson CL, Elkassabany NM, Kamath AF, Liu J. Low albumin levels, more than morbid obesity, are associated with complications after TKA. Clinical Orthopaedics and Related Research 2015 473 3163–3172. (https://doi.org/10.1007/s11999-015-4333-7)
