A trimalleolar ankle fracture is considered unstable and treatment is generally performed operatively. Computed tomography is important for the operative planning by providing an elaborated view of the posterior malleolus.
Trimalleolar ankle fractures have a rising incidence in the last decade with up to 40 per 100,000 people per year. With a growing number of elderly patients, trimalleolar ankle injuries will become more relevant in the form of fragility fractures, posing a particular challenge for trauma surgeons.
In patients with osteoporotic trimalleolar ankle fractures and relevant concomitant conditions, further evidence is awaited to specify indications for open reduction and internal fixation or primary transfixation of the ankle joint.
In younger, more demanding patients, arthroscopic-assisted surgery might improve the outcome, but future research is required to identify patients who will benefit from assisted surgical care.
This review considers current scientific findings regarding all three malleoli to understand the complexity of trimalleolar ankle injuries and provide the reader with an overview of treatment strategies and research, as well as future perspectives.
Cite this article: EFORT Open Rev 2021;6:692-703. DOI: 10.1302/2058-5241.6.200138
The human ankle joint complex can be divided in a talocrural, a talocalcaneonavicular and a subtalar part.1 The talocrural (TC) joint is formed by three bones and a complex ligamentous apparatus. Tibia, fibula and talus are interconnected through collateral ligaments and the syndesmotic ligament complex.2,3
From the tibia, the facies articularis medialis (pilon) and the facies articularis inferior are connected to the talus. Looking at the coronal plane, the tibia shows a slight slope from medial to lateral and is concave-shaped in the sagittal plane (Fig. 1B). Considering the bone mineral density of the tibia, the articular site shows a higher density in comparison to the metaphysis.4–6 Besides the connection between tibia and talus, there exists a close interaction between tibia and fibula. The concave-shaped incisura tibialis matches the convex shape of the fibula (Fig. 1C). The incisura tibialis is formed by the anterior (Chaput’s tubercle) and posterior tubercle of the tibia (Fig. 1C). Likewise, the anterior (Le Fort-Wagstaffe tubercle) and posterior tubercle of the fibula form a convex triangle. The contact zone between tibia and fibula is covered by a thin layer of cartilage forming the syndesmotic recess.7
Furthermore, the fibula is connected with the corresponding articular surface of the talus.8 Due to the length of the fibula, the articular portion reaches further in distal direction in comparison to the medial malleolus.2 Via the syndesmotic complex, the fibula is dynamically fixed to the tibia (Fig. 1 D).9
Over half of the surface of the talus is covered with cartilage without any tendon insertions.10 The shape of the talus is complex, resulting in a changing axis of rotation.11 Looking from above at the trochlea tali, it is wedge-shaped with a broader anterior portion.3 On the medial side, the articulation between talus and malleolus shows a larger contact surface.5,12 In the sagittal plane, there also exists an incongruity between the articular surface of the talus and the distal tibia. The convex-shaped talus has a greater articular surface than the corresponding concave-shaped facies articularis inferior of the tibia (Fig. 1B).13
In the frontal plane, the trochlea of the talus shows a lateral slope of about nine degrees.12 The surface of the talus forms an arched deepening from ventral to dorsal direction, ensuring a rotational stability in dorsoplantar movements.3,12
The ligamentous apparatus of the TC joint can be differentiated into the lateral (LCL), the medial (MCL) and the tibiofibular ligament complex. Among the ligamentous structures of the syndesmosis are the distal anterior tibioﬁbular ligament (ATIFL), the distal posterior tibioﬁbular ligament (PTIFL), the transverse ligament and the interosseous ligament (Fig. 1D). Proximal to that, the interosseus membrane forms also part of the tibiofibular complex.7 All of these structures stabilize the ankle mortise and at the same time allow movements of the fibula in relation to the tibia.14 The ATIFL is trapezoidal-shaped and extends from the Chaput tubercle to the Wagstaff tubercle.15 In the literature, an accessory ligament, called Bassett’s ligament, running inferior and parallel to the ATIFL is described.16 Between the fascicles of the ATIFL lie perforating branches of the peroneal artery.14 In comparison to the interosseous ligament, the ATIFL is weaker, contributing to the fact that the ATIFL can be ruptured, but the interosseus ligament with the osseous membrane remains intact.17 The interosseus ligament is the distal continuation of the osseous membrane and is pyramid-shaped.18 The PTIFL is a strong ligament running from the posterior tibia in distal-lateral direction to the posterior tubercle of the fibula.7 It can be differentiated into a superficial and a deep part, also called the transverse ligament. The transverse ligament runs more horizontally and forms a labrum analogue.7 A frequent anatomic variation is the intermalleolar ligament between PTIFL and transverse ligament.19,20
The LCL complex consists of the anterior talofibular (ATFL), the calcaneofibular (CFL), and the posterior talofibular (PTFL) ligaments. The ATFL typically shows a double-banded morphology and is separated by vascular branches.14,21 It is almost horizontally located to the ankle in neutral position and depending on the position of the foot, one band tightens while the other relaxes.14 Due to its characteristics, it limits anterior displacement of the talus and plantar flexion of the ankle.22 The CFL originates below the ATFL at the fibula and inserts at the posterior region of the lateral surface of the calcaneus.14 Its fibres run obliquely backwards/downwards and the CFL is located directly underneath the peroneal tendons. It is the only ligament of the LCL complex that bridges the TC and subtalar joint.14 The PTFL runs almost horizontally from the fibula to the posterior process of the talus. Single fibres can reinforce the intermalleolar ligament. In neutral position, the PTFL is relaxed and tightens in dorsiflexion.14
The MCL complex (deltoid ligament) consists of a superficial and deep layer. It is a fan-shaped complex reaching from the medial malleolus to the talus, calcaneus and navicular bone, bridging the TC and subtalar joint.23 The sheaths of the tibialis posterior and flexor hallucis tendons pass above the MCL complex.14
The ankle joint is not solely a hinge joint around a constant axis, but rather allows combined rotatory and hinge movements. The axis of rotation changes depending on the degree of dorsiflexion/plantarflexion, leading to a complex movement of the talus in sagittal, coronal and frontal plane.24,25 Due to the interactions between tibia and fibula, the subtalar joint and the Chopart joint, the dorsiflexion leads to an internal rotation, valgization of the rear foot and pronation of the forefoot, whereas in plantarflexion, it comes to an external rotation, varization of the rear foot and supination of the forefoot.2,11,25,26 The normal range of motion in the sagittal plane is 13–33° of dorsiflexion and 23–56° of plantarflexion. Motions in the transverse (internal/external rotation) and coronal plane (varus/valgus) are coupled with motions in the sagittal plane.24
Ankle fractures are common and account for up to 10% of all bone injuries with a rising incidence over the last decades.27,28 According to a nationwide population study in Sweden, closed bi- or trimalleolar fractures had an annual incidence rate of 33 per 100,000 person-years and 20 to 40 per 100,000 persons-years in Denmark.28,29 Interestingly, the peak incidence of trimalleolar fractures is in the age from 60 to 69 years, becoming the second most common ankle fracture type in this age group.28 Elderly women are especially at risk, since women over 60 years with bi- or trimalleolar fracture have the highest incidence of open ankle fractures.29 Due to the predominance in elderly women, some authors claim that trimalleolar fractures should be regarded as fragility fractures.28 There also exists a seasonal variation with increased incidences for ankle fractures during cold winters.28
Different mechanisms, ranging from low to high-energy trauma, can lead to complex ankle fractures with falls from standing heights in combination with ankle distortion presenting the most common cause.28,29 Especially in women over 60 years, falls from a standing position account for over two-thirds of all cases.29 Trimalleolar ankle fractures are typically the result of a low-energy trauma.30
A trimalleolar ankle fracture typically involves the distal fibula (lateral malleolus), medial and posterior malleolus. The first ankle fracture classification system developed by Percival Pott differentiated between uni-, bi- and trimalleolar ankle fractures.31 Despite the reproducibility, the classification system lacks the distinction between stable and unstable fractures.32,33 Lauge-Hansen developed a classification system for ankle fractures based on the mechanism of injury.34 It describes the position of the foot at the time of trauma and the direction of the deforming force.35 Depending on the severity of the ankle injury, different stages (I-IV) can be distinguished. Providing further information about the stability of the injury, the Lauge-Hansen classification had become a widely used classification system for ankle injuries.32 According to the Lauge-Hansen classification, a trimalleolar fracture of the ankle can either be classified as SE IV or PE IV. But the Lauge-Hansen classification system has been challenged due to a poor reproducibility and low inter- and intraobserver reliability.36–39
One of the most commonly used classifications for ankle fractures is the Weber classification, which differentiates fibular fractures relevant to the tibiofibular syndesmosis.40 Despite the fact that the Weber classification system has a high inter- and intraobserver reliability, it is inadequate for multimalleolar fractures.41,42
Biomechanical and clinical research led to the development of classification systems of the medial and posterior malleolus. Medial malleolar fractures can be classified according to Herscovici et al, who differentiate between four types (A–D) of fractures based on the anteroposterior radiograph.43 It is the current standard system regarding the medial malleolus, but inadequate for multimalleolar fractures.44 Indication for operative treatment of medial malleolus fractures rather depends on the degree of displacement and whether it is part of an unstable ankle fracture.44
The posterior malleolus can be classified according to Haraguchi, Bartoníček or Mason. The former developed a computerized tomography (CT)-based classification system for posterior malleolus fractures depending on transverse CT sections.45 Mason et al modified the Haraguchi classification indicating the severity and pathomechanism of the fracture.46 Bartoníček et al postulated a more specific CT-based classification system that also takes the stability of the tibiotalar joint and the integrity of the fibular notch into consideration.47 These classification systems of the posterior malleolus can guide further operative or non-operative treatment, but fail to fully characterize the kind of trimalleolar fracture.
The AO/OTA classification distinguishes between Type A (infra-syndesmotic), B (trans-syndesmotic) and C (supra-syndesmotic) fibular fractures.48 Furthermore, AO/OTA Type B2.3 or B3.3 fractures are trans-syndesmotic fibular fractures with a fracture of the posterolateral rim and medial malleolus. The same applies for AO/OTA type C1.3 and C2.3 fractures involving all three malleoli. Additional qualifications can be added to specify the stability of the syndesmosis or concomitant injuries (e.g. Le Fort-Wagstaffe tubercle). The AO/OTA classification lacks a description of the fracture configuration of the medial and posterior malleolus. This is noteworthy, since the size of the posterior fragment and displacement are factors to consider for the choice of treatment.49
Ideally, a classification system should have a high inter-/intraobeserver reliability, be widely recognized, relevant for prognosis and applicatory in research and clinic. The most comprehensive classification system is the AO/OTA classification. It is widely recognized, easy to use in clinical practice and provides information about the kind of trimalleolar fracture with focus on the fibula. However, an important factor, the configuration of the posterior malleolus fragment, is not represented in the AO/OTA classification.
In general, it is accepted that trimalleolar fractures are treated operatively.50,51 But in selected groups, where satisfactory initial closed reduction is possible, a conservative treatment can lead to a comparable outcome.52 A randomized controlled trial comparing close contact casting with surgery of unstable ankle fractures among 620 older adults found satisfactory results following conservative treatment.53 Even after three years of non-operative treatment, the equivalence in function between both groups remained.54 The conservative therapy consisted of a close contact cast below the knee applied under anaesthesia, non-weight-bearing for four weeks and full weight-bearing by week six to eight. Regular radiographs were conducted to monitor joint congruency.53 Nineteen percent of patients needed conversion to internal fixation due to a loss of fracture reduction, and the non-operative group had a six times higher probability of a radiologic malunion.53 Unfortunately, the type of malleolar fracture was only described as relevant to the syndesmosis and not classified according to one of the common classification systems. Due to that fact and the exclusion criteria of the study, the results should be interpreted with caution and cannot simply be transferred to the management of trimalleolar ankle fractures.
In contrast, a prospective randomized study of 43 patients with displaced ankle fractures in patients aged over 55 years showed an inferior outcome for non-operative treatment.55 Thirty-eight percent of the conservative group showed a loss of reduction and a limited range of motion in comparison to the open reduction and internal fixation (ORIF) group at follow-up.55
A retrospective study of 19 patients with non-operatively treated displaced bimalleolar and trimalleolar fractures reported an excellent functional outcome after 20 years.56 However, it is not feasible to draw reliable conclusions for the treatment of trimalleolar fractures, because only four patients with a trimalleolar fracture were available for final clinical and radiological evaluation.
The current literature strongly advocates the operative treatment of ankle fractures involving the posterior malleolus. In their critical review, Rammelt and Bartoníček analysed the importance of the posterior malleolus with conclusive data supporting the direct open reduction and fixation of posterior malleolar fragments.57 Vacas-Sánchez et al proposed a CT-based algorithm for fixation of the posterior malleolus and Wang et al showed good functional outcomes following operative treatment of the posterior malleolus.58,59
Timing to surgery
Depending on the fracture configuration, the management and timing to definite surgery can differ significantly. Dislocated trimalleolar ankle fractures should be reduced immediately, re-establishing joint congruity and reducing concomitant soft tissue injury.60 If closed reduction is unsatisfactory, an immediate open reduction should be achieved. Furthermore, emergency indications for an operative treatment are:
severe soft tissue injury,
Despite the emergency operative treatment, there is a controversy about the optimal timing of surgery of closed trimalleolar ankle fractures. It spans from the period of a few hours up to several days of delay in order to minimize soft tissue swelling.63 A retrospective cohort study in Norway with 1011 patients showed no difference regarding postoperative length of stay, complications, and functional outcomes in patients with closed ankle fractures treated with ORIF during the first 8h, 8h to 6 days and > 6 days.64 Other studies are in line with these findings, reporting no difference regarding postoperative wound infections between early and delayed surgery groups.65–67 In contrast, a case series of Schepers et al found a significant difference regarding wound complications between patients treated within one day and with delay.68 They also performed a literature review including six studies showing a significant increase of wound complications when surgery was delayed.63,66,68-73 Considering the published studies, their heterogeneity and partially low quality, there is no definite recommendation for the optimal timing of the operative treatment of closed ankle fractures (Table 1). In clinical practice, the evaluation of soft tissue status is still an important piece of information and can lead to a delayed surgery in case of excess soft tissue swelling.66 Latest studies showed no difference regarding different time categories and further studies are necessary to determine the best timing of surgery. In clinical practice, the time of surgery also depends on staff and operating capacities so that definite operative treatment is neither feasible nor successful in many cases.
Overview timing to surgery of closed ankle fractures
|Author||Journal/Year||Timing to surgery|
|Naumann64||Injury 2017||Up to 6 days|
|Breederveld65||Injury 1988||5 to 8 days|
|Singh66||Journal of Orthopaedic Surgery 2015||Within 24 hours|
|Schepers68||International Orthopaedics 2013||Within 24 hours|
|Saithna63||European Journal of Orthopaedic Surgery & Traumatology 2009||Up to 6 days|
|Carragee69||The Journal of Bone and Joint Surgery [Br] 1991||Up to 4 days|
|Carragee70||The Journal of Trauma 1993||Within 24 hours|
|Høiness71||Annales Chirurgiae et Gynaecologiae 2000||Within 8 hours|
|Adamson72||Injury Extra 2009||Within 24 hours|
|Sukeik73||Orthopaedic Proceedings 2011||Within 24 hours|
For choosing the optimal surgical treatment and implants, there are some important factors to be considered:
Soft tissue injury
Bone mineral density (non-osteoporotic vs. osteoporotic)
Functional demand of the patients
Trimalleolar ankle fractures with severe soft tissue injury or open fractures pose a particular challenge. The incidence of open ankle fractures is about 3%, but is expected to increase especially in older patients.29,74,75 An open ankle fracture is an independent risk factor for wound complications and thus for a poorer outcome.76 Concomitant conditions such as diabetes, smoking or vascular diseases increase postoperative wound complications and can lead to an amputation below the knee.77–80 In these selected cases with severe soft tissue injury and relevant concomitant injuries, an external fixation might be a viable option for fracture treatment.81
The management of osteoporotic ankle fractures is challenging and internal fixation is associated with an increased risk of sepsis, nonunion, malunion and delayed wound healing.82–84 In elderly patients, tibio-talo-calcaneal (TTC) nailing is an alternative surgical treatment option.85–87 A prospective randomized control trial by Georgiannos et al showed that elderly patients following tibio-talo-calcaneal nailing had fewer postoperative complications in comparison to open reduction and internal fixation.85 The mean age of patients treated with TTC ranged from 77 to 82 years with an Olerud and Molander ankle score of < 60, representing an elderly low-demanding patient population.85–87 The peak incidence of trimalleolar fractures is in the age from 60 to 69 years and thus primary ankle transfixation with TTC does not present the optimal operative treatment in these cases. In the following, the surgical options to anatomically restore the ankle joint function in trimalleolar ankle fractures will be outlined.
The standard approach is a lateral incision above the distal fibula. In the classical AO technique, open anatomical reduction is secured, fixed with a lag screw and a lateral neutralization plate (e.g. one-third tubular plate).40,60 Today, this technique and implants are commonly used in daily routine.88
In elderly patients with reduced bone mineral density, lateral locking plates can be advantageous in comparison to traditional compression plating when soft tissue coverage is sufficient.89 Biomechanical studies showed that locking plates provide a higher construct stability in specimens with reduced bone mineral density.90,91 In trimalleolar ankle fractures with normal bone mineral density, fibular locking plates do not show a mechanical advantage.92 But the use of locking compression plates results in a better clinical and radiological outcome in comparison to standard one-third tubular plates.93 The level and extent of fibular injury needs to be considered when choosing the adequate plating system. Disadvantages of locking plates are that they provide minimal compression across the fracture (without lag screw), higher costs and ‘thicker’ plate size, causing a possibly higher wound complication rate.89,94,95 But in a randomized control trial comparing locking and non-locking neutralization plates, there was no difference regarding the complication rates.96 Minimally invasive locking plate osteosynthesis of distal fibular fractures may be a viable option in critical soft tissue conditions.97 Therefore, a smaller incision is made at the distal end of the fibula and the locking plate is inserted from the distal side in a proximal direction using a locking drill sleeve.97 Furthermore, a locking plate system allows to safely fix distal fragments with small fragment locking screws in distal fibular fractures.89
Beside the standard lateral plating, posterolateral antiglide plate fixation is an alternative. Biomechanical studies showed an improved construct stability in comparison to lateral locking plates in osteoporotic bone.98 Posterolateral and posterior antiglide plate fixation led to satisfactory clinical and radiological outcome comparable to lateral plating.99–101 A significant complication of posterolateral plating is a peroneal tendon lesion, that can lead to high rates of hardware removal.102 But the more currently conducted studies report a low complication rate, including minimal presence of peroneal lesions.99,103 The antiglide plate can be inserted via a lateral or posterolateral approach, depending on the fracture configuration. A posterolateral approach is used in case of a concomitant fracture of the posterior malleolus requiring open reduction and internal fixation.100,104 The distal fibula is openly reduced and fixed from the posterior side with a neutralizing one-third tubular plate with or without lag screw.100
In contrast to open surgical fixation of distal fibular fractures, a percutaneous method was developed to minimize soft tissue stress while providing a reliable fixation method. Biomechanically, an intramedullary fibular nail provides a robust construct stability with a greater torque-to-failure compared to standard plating.105 A prospective randomized control study in elderly patients showed a lower wound infection rate of fibular nailing in comparison to standard ORIF and a superior cost-effectiveness.95 Especially in high risk patients, fibular nailing seems to be a safe treatment choice with a low infection complication rate.106 A review of 1008 patients treated with intramedullary fixation of distal fibular fractures states excellent clinical and functional outcomes.107 Due to the closed reduction and mini-incision technique at the distal tip of the fibula, comminuted fractures pose a difficulty, whereas intramedullary nailing can be impossible and conversion to plate fixation is mandatory.108 There are some technical difficulties that need to be taken into consideration. The distal fibular entry point is crucial, the base of the nail should be left flush with the cortex at the tip of the fibula, one distal locking screw is sufficient and the careful placement of one or two proximal locking screws is essential.109 Modern fibular nail implants provide several options for distal locking screws.110
The indications for fixation of the posterior malleolus are disputed.111–114 A review about the long-term outcome of 866 posterior malleolar fractures reported comparable results of operatively and non-operatively treated patients.112 If a stable ankle mortise can be achieved through medial and lateral fixation and there is no joint impaction or a large intercalated fragment, patients may not benefit from posterior plating considering the additional risks.114
For a long time, the extent and displacement of the posterior malleolus fragment was decisive for indication to surgery. A fragment displacement of more than 2 mm or the involvement of one-quarter to one-third of the articular surface on the lateral radiograph were critical indications for operative treatment.115–118 CT-based classifications of the posterior malleolus were developed, since the interpretation of plain radiographs poorly assess the posterior fragment size and configuration.47,119,120 The proposed classification by Bartoníček and Rammelt may be used as a guide for decision making, but important factors have to be considered. Operative treatment aims to re-establish posterior stability while restoring the size and articular surface of the tibial pilon, the stabilizing function of the posterior tibiofibular ligament and the integrity of the fibular notch.121 The quality of reduction and joint congruity are significant factors influencing prognosis.122 To achieve these goals, there are different operative strategies depending on the fragment configuration and concomitant injuries. Open reduction and internal fixation can be performed direct or indirect.121,123 Indirect methods involve anterior to posterior (AP) screw fixation and transfibular reduction with AP screws.123
AP screws are indicated in non-displaced single, large fragments of the posterior malleolus without intercalary fragment (Bartoníček and Rammelt Type 4).121 The posterior malleolus is reduced by ligamentotaxis and secured with a pointed reduction clamp between the anterior and posterior tibial tubercles. Following radiographic confirmation and ideally direct visualization of the reduction, the fragment is fixed with anterior to posterior screws.57 Biomechanical and clinical studies showed that AP screw fixation seems to be inferior compared to buttress/posterolateral plating.115,116,124 This is a fact the surgeon has to consider before choosing the fixation method, but also weighing the contributed risks of the different approaches.
Direct reduction of the posterior malleolus can be achieved via a posteromedial or posterolateral approach. The posterolateral approach is indicated in posterior malleolus fractures with relatively small diameter (Bartoníček and Rammelt Type 2 & 4) and the presence of intercalary fragments.121 According to the Mason classification, Mason Type 2 and 3 posterior malleolar fractures are treated with a posterolateral approach and only Type 1 fractures with trans-syndesmotic fixation.125 The posterolateral approaches allow open reduction and internal fixation of the posterior malleolus as well as the treatment of distal fibular fractures.99 Open reduction and internal fixation of the posterior malleolus can be performed with posterior screw or plate fixation depending on the fracture configuration and bone quality.121 There is no uniform recommendation for when to use screws, e.g. 3.5 mm lag screws, one-third tubular plates or locking plates. In osteoporotic bone, a locking plate fixation might be advantageous.126 Important structures that are at risk are the sural nerve, peroneal tendons and the flexor hallucis longus muscle.121,127 In a cadaveric study, lesions to the tibialis anterior tendon were seen through posterior to anterior K-wires.128 The posterolateral approach offers advantages over indirect fixation methods involving direct visualization and reduction as well as the possibility to remove small osteochondral fragments.121 Clinical studies showed a better outcome of direct posterior in comparison to indirect reduction with comparable complication rates.129–132 In comparison to the indirect fixation method, the posterolateral approach is currently endorsed, but large randomized control trials are needed to prove its superiority.
The posteromedial approach is useful in posterior malleolus fractures with a posteromedial fragment involving the medial malleolus (Bartoníček and Rammelt Type 3).104,121 It can also be combined with a posterolateral approach to treat trimalleolar fractures with the involvement of the entire posterior plafond.133,134 Similar to the posterolateral approach, open fracture reduction of the posterior and medial malleolus can be secured with screws and/or plates.135 Structures at special risk are the tibialis posterior tendon, flexor digitorum longus muscle and the neurovascular bundle.121 If an appropriate reduction can be achieved, the outcome is satisfactory with low complication rates.104,133,135 But the studies included only small patient numbers and long-term outcomes are missing.
In trimalleolar ankle fractures, the trend goes towards directly fixing the posterior malleolus fragment since it leads to a superior quality of reduction and better clinical outcome.131,132,136 Direct fixation can prevent syndesmotic diastasis and thus contributes to prompt rehabilitation.113,137 In a current study, Yang et al propose that in cases without fixation of the posterior malleolus, the syndesmotic screw should be removed three months postoperatively since early removal led to a higher rate of syndesmotic diastasis.137 Open reduction and internal fixation of the posterior fragment restores the integrity of the posterior portion of the syndesmosis and thereby reduces the need for trans-syndesmotic fixation.57,131,136,138,139 But if the intraoperative testing after fracture fixation shows a syndesmotic instability, an additional trans-syndesmotic fixation is necessary. Trans-syndesmotic fixation can be achieved through dynamic or static fixation. A meta-analysis of 11 cadaveric studies showed that a dynamic fixation system (suture button) provides less rigidity in comparison to metal screws.140 Looking at the clinical and radiological outcome, the dynamic fixation for acute syndesmotic injuries is superior compared to static screw fixation.141–144 But these studies included mainly syndesmotic injuries with or without a unilateral malleolar fracture.141–144 Thus, these results cannot simply be transferred to the treatment of trimalleolar ankle fractures and future studies need to prove superiority of dynamic stabilization devices.
Traditionally, open reduction and internal fixation of medial malleolus fractures is indicated in trimalleolar ankle fractures.44 Considering the age distribution and peak incidence of trimalleolar ankle fractures, fixation of the medial malleolus may provide an additional stability in these osteoporotic bones.50 But Hoelsbrekken et al showed that non-operative management of minimally displaced medial malleolus fractures after fracture reduction in bi- or trimalleolar ankle fractures results in equivalent outcomes.145 A prospective randomized controlled trial regarding the management of medial malleolus fractures in unstable ankle fractures is awaited, hopefully providing further Level I evidence.146
Operative management includes open and percutaneous techniques with tension-band wiring, plate and/or screw fixation. Open surgical approaches are the anteromedial and direct medial approach. Advantages are the direct visualization of the fracture, inspection of the articular surface and possibility to retrieve interposing reduction obstacles.44 Due to the extensile approach, soft tissue is more likely compromised and the great saphenous vein and nerve are at special risk when performing an anteromedial approach.44 This has led to the development of minimally invasive and solely percutaneous techniques. With a minimally invasive approach, the articular surface can be inspected via a mini-arthrotomy, fracture reduction visualized and fixation performed through percutaneous screw fixation.147 Advantages are the reduced soft tissue stripping, but especially purely percutaneous screw fixation can compromise bone union due to interposing periosteal flaps.148 The choice of implant depends on fracture configuration, bone quality and soft tissue injury. Screws are the most frequently used implant and are indicated in oblique fractures of the medial malleolus.149 Following the traditional AO technique, two parallel partially threaded cancellous lag screws are inserted – preferably into the anterior colliculus.44 This classic approach is challenged by a randomized control trial by Buckley et al, who compared double to single-screw fixation and found comparable results.150 In osteoporotic bone, fully threaded screws or even bicortical fixation can provide more compression and lower rates of radiological loosening.151,152
In cases of distal avulsions (Herscovici type B) or severe comminution, stainless steel tension-band wiring (TBW) constructs are superior in comparison to screws.153 Also, in transverse fractures of the medial malleolus (Herscovici type C), TBW seems to be advantageous.149 The disadvantage of TBW is the frequently observed wire migration in up to one fifth of patients and prominent metalwork causing medial pain and implant removal.154,155 Due to these associated complications, new low-profile knotless systems were developed that still need to prove their reliability.156
In vertical fractures (Herscovici type D) of the medial malleolus, antiglide plating provides a biomechanical superior fixation compared to screws.157 Due to a higher load to failure and increased compression of the fracture, antiglide plating should be used with additional lag screws.44 The disadvantage of plate fixation is a larger exposure, as compared to screws requiring good soft tissue conditions.
New implants, such as headless or bioabsorbable screws were developed to reduce medial site pain and supersede implant removal, but prospective studies with a high scientific quality are missing to justify routine clinical use.44
Arthroscopic-assisted open reduction and internal fixation (AORIF)
In recent years, there has been a growing number of studies regarding arthroscopic-assisted open reduction and internal fixation (AORIF) in acute ankle fractures.158–160 A review analysing the long-term outcome after 1822 operatively treated ankle fractures showed that only 79.2% of the optimally reduced fractures showed a good to excellent long-term outcome.51 Due to the arthroscopic findings in acute ankle fractures, the unsatisfactory results in optimally reduced fractures are attributed to traumatic chondral lesions.161–164 But the majority of studies performing AORIF included isolated malleolar fractures 158. Only one study compared ORIF and AORIF in bimalleolar or trimalleolar ankle fractures.158,160 Baumbach et al showed that patients with bimalleolar or trimalleolar ankle fractures following AORIF in comparison to ORIF had a significantly better outcome regarding the functional score four years after surgery.160 The median age of the included patients undergoing AORIF was 46 years, representing a younger and higher-demand patient population, in which arthroscopic-assisted ankle surgery is typically performed.158,160 Due to the fact that there only exists one comparative study regarding AORIF in trimalleolar ankle fractures, further studies providing Level I evidence for indications of arthroscopic-assisted surgery in trimalleolar ankle fractures are awaited.
In the authors’ opinion, future research regarding trimalleolar ankle fractures will need to focus on two different patient populations and their distinct characteristics to derive appropriate treatment protocols. On the one side, there is a growing number of elderly patients with osteoporotic fractures and relevant concomitant conditions in which internal fixation to restore anatomical ankle joint congruity poses a particular challenge. Future studies need to provide further evidence to specify indications for open reduction and internal fixation or primary transfixation of the ankle joint in these elderly patients. On the other side, the current trend towards direct fixation of the posterior malleolus needs to prove superiority regarding the long-term outcome in comparison to indirect surgical techniques in trimalleolar ankle fractures. In younger, higher-demanding patients, arthroscopic-assisted open reduction and internal fixation might improve the outcome, but studies are needed to identify patients who will benefit from assisted surgical care.
Trimalleolar ankle fractures are unstable and their treatment is generally facilitated operatively. Computed tomography is essential for classification and operative planning. The posterior malleolus gained in importance in the last few years and current clinical evidence is endorsing direct open reduction and internal fixation to provide a stable and accurate reduction. Incidence of trimalleolar fractures peaks in higher age groups and is becoming more relevant in fracture care in the future due to the demographic development. Elderly patients with osteoporotic trimalleolar ankle fractures and concomitant conditions pose a particular challenge and further evidence is needed regarding the optimal surgical treatment.
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The authors would like to thank Fritz Seidl, M.A. Interpreting and Translating, for proof-reading and language-editing the manuscript.
The authors declare no conflict of interest relevant to this work.
No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.
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