New advances in intra-operative imaging in trauma

in EFORT Open Reviews
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Peter H. Richter Orthopaedic Trauma Department, Universität Ulm, Germany

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Florian Gebhard Orthopaedic Trauma Department, Universität Ulm, Germany

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Alexander Eickhoff Orthopaedic Trauma Department, Universität Ulm, Germany

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Konrad Schütze Orthopaedic Trauma Department, Universität Ulm, Germany

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P. H. Richter, Department of Trauma, Hand, and Reconstructive Surgery, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm, Germany. Email: peter.richter@uniklinik-ulm.de
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  • The invention of flat-panel detectors led to a revolution in medical imaging. The major benefits of this technology are a higher image quality and dose reduction. Flat-panel detectors have proved to be superior to standard C-arms (= C-arm with radiograph source and image intensifier).

  • Cone-beam computed tomography (cone-beam CT) is a 3D data set, which can be acquired with a flat-panel detector. The cone-shaped beam is used for 3D data generation. For cone-beam CT acquisition, the flat-panel detector rotates around the patient lying on the operating table. Intra-operative cone-beam CT can be a very helpful tool in orthopaedic surgery. Immediate control of fracture reduction and implant positioning in high image quality can reduce the need for secondary revision surgery due to implant malposition.

  • In recent years there has been a revival of standard fan beam CT technology in operating rooms. Fixed and mobile systems are available. Fixed systems are typically placed on a sliding gantry. Different mobile intra-operative CT scanners were recently introduced. Due to their mobility, they are not bound to a specific operating room. The use of standard intra-operative CT scanners results in high 3D image quality but, in comparison with a cone-beam CT scanner, fluoroscopy is not possible.

  • The introduction of flat-panel detectors has led to improvements in intra-operative image quality combined with dose reduction. The possibility of high-quality 3D imaging in combination with navigation can assure optimal implant placement. Due to immediate control of the osteosynthesis, revision surgery at a later time can be prevented.

Cite this article: EFORT Open Rev 2018;3 DOI: 10.1302/2058-5241.3.170055

Abstract

  • The invention of flat-panel detectors led to a revolution in medical imaging. The major benefits of this technology are a higher image quality and dose reduction. Flat-panel detectors have proved to be superior to standard C-arms (= C-arm with radiograph source and image intensifier).

  • Cone-beam computed tomography (cone-beam CT) is a 3D data set, which can be acquired with a flat-panel detector. The cone-shaped beam is used for 3D data generation. For cone-beam CT acquisition, the flat-panel detector rotates around the patient lying on the operating table. Intra-operative cone-beam CT can be a very helpful tool in orthopaedic surgery. Immediate control of fracture reduction and implant positioning in high image quality can reduce the need for secondary revision surgery due to implant malposition.

  • In recent years there has been a revival of standard fan beam CT technology in operating rooms. Fixed and mobile systems are available. Fixed systems are typically placed on a sliding gantry. Different mobile intra-operative CT scanners were recently introduced. Due to their mobility, they are not bound to a specific operating room. The use of standard intra-operative CT scanners results in high 3D image quality but, in comparison with a cone-beam CT scanner, fluoroscopy is not possible.

  • The introduction of flat-panel detectors has led to improvements in intra-operative image quality combined with dose reduction. The possibility of high-quality 3D imaging in combination with navigation can assure optimal implant placement. Due to immediate control of the osteosynthesis, revision surgery at a later time can be prevented.

Cite this article: EFORT Open Rev 2018;3 DOI: 10.1302/2058-5241.3.170055

Introduction

A rapid evolution in technology can be observed all over the world. Whether it is electric self-driving cars, drone transportation or outer space travel, it is difficult to keep up with all the novelties we are confronted with on a daily basis. This evolution does not stop at the gates of medicine, which has also led to major advances in intra-operative imaging. Without intra-operative imaging, modern orthopaedic trauma surgery would not be possible. Most surgical procedures are highly dependent on optimal intra-operative visualization. Standard C-arms are equipped with a radiograph source and image intensifier. New implants and the trend for minimally invasive surgery and approaches made progression in intra-operative imaging inevitable. Because of a rapid evolution in intra-operative imaging, it is challenging to maintain an overview of the new technology and systems which are currently available. The aim of this publication is to present the latest advances in intra-operative imaging in trauma surgery.

But what exactly are the demands of the new and innovative intra-operative imaging devices for this special field of surgery?

The primary and main purpose of an imaging device is to assure an excellent image quality. Ideally, image quality should be increased without an accompanying increase in radiation. Further, important demands are a large field of view, the possibility of collimation and magnification, artifact reduction, 3D capability and other tools such as automatic implant detection or length measurement. Moreover, a combination with a navigation system should be possible.

Flat-panel detectors

The invention of flat-panel detectors led to a revolution in medical imaging. In the beginning, these detectors could only be installed in fixed systems. The major benefits of this technology are a high image quality and dose reduction compared with a standard C-arm. 1 Weis et al compared the radiation dose during paediatric interventions using a flat-panel and a standard C-arm. A significant reduction of radiation with the flat-panel C-arm could be seen (upper gastro-intestinal investigation 45 ± 38 μGy*m2 versus 11 ± 9 μGy*m2). 2,3 Furthermore, the use of flat-panel detectors results in zero geometrical distortion, wider dynamic range and high spatial resolution (pixel size 100 to 194 µm versus 2.2 to 3.5 Lp/mm). 4 A total of 60 536 grey levels can be visualized with flat-panel detectors, which is a 16-fold increase compared with standard C-arms. This leads to improved soft-tissue visualization.

Nowadays, flat-panel technology can also be incorporated into mobile C-arms (Fig. 1), which are mandatory for most orthopaedic procedures. 5 They are suitable for orthopaedic surgery as their use assures optimal dose efficiency in the operating room. Guillou et al discovered that mobile flat-panel C-arms can reduce the intra-operative dose compared with fixed systems during endovascular interventions. 6 Another major benefit of flat-panel detectors is the increased field of view of fluoroscopic images due to a larger detector diameter compared with standard C-arms. The detector size can reach up to 43 × 43 cm, in mobile C-arms 30 × 30 cm versus a maximum 31 cm diameter (standard C-arm). The entire pelvis can be visualized with a single fluoroscopic image. 7,8 Furthermore, because of a slimmer detector form, the ‘source to image distance’ is increased, leading to more workspace (⩽ 93 cm) for the surgeon and minimally invasive instruments. Another feature of modern mobile flat-panel C-arms is asymmetric collimation to motorized steering, giving the surgeon the possibility to store multiple positions, which can be reached automatically. 9

Fig. 1
Fig. 1

Mobile flat-panel detector with large source to image distance.

Citation: EFORT Open Reviews 3, 5; 10.1302/2058-5241.3.170055

Despite the many superior properties of flat-panel C-arms, many hospital administrations are still reserved regarding its purchase because of high acquisition costs. Patient and staff radiation safety is certainly of utmost importance, and therefore costs should not be the most relevant factor if a new C-arm is needed. It can be very confusing to decide which C-arm is most suitable for different surgical departments. The surgeon has to keep in mind that the C-arm choice is directly linked to image quality and dose efficiency. Even among flat-panel C-arms there are significant differences regarding these entities. 10

Cone-beam computed tomography

Cone-beam CT is a 3D data set, which can be acquired with a flat-panel detector. The cone-shaped beam is used for 3D data generation. For cone-beam CT acquisition, the flat-panel detector rotates around the patient lying on the operating table. Afterwards, the data set is sent to a computer for post-processing and a 3D image is generated. This data set can be visualized in multiplanar reconstructions (MPR) or volume-rendered in 3D (volume-rendering technique (VRT)). 11 Limitations include increased artifacts due to scatter radiation compared with a regular CT.

A comparison between cone-beam and standard multi-slice fan beam CT regarding the intra-operative radiation dose remains difficult. Neither system has been proven to be superior so far. 12,13 We evaluated different 3D cone-beam protocols in comparison with a multi-slice CT using Rando-Alderon phantoms. At the thoracolumbar junction, a high- and low-dose cone-beam protocol was used. The dose of the high-dose protocol was comparable with the CT. However, it could be reduced by 75% due to the low-dose protocol. Therefore, it is mandatory to use the ideal protocol for the correct anatomical region and intervention. 14 Most of the systems on the market were initially used for vascular and cardiac interventions or procedures. Intra-operative cone-beam CT can be a helpful tool in orthopaedic surgery as well. Immediate control of fracture reduction and implant positioning in high image quality can reduce the need for secondary revision surgery due to implant malposition. 15

Different systems are now available for orthopaedic surgery. The most prominent system is the o-arm (Medtronic, USA). It is a mobile cone-beam CT typically used for spine surgery. Only a few other indications have been published, ranging from sternoclavicular dislocation to syndesmotic reduction. 16,17 The main indication of the o-arm remains in pedicle screw placement in combination with an intra-operative navigation system. The combination of these systems can reduce the pedicle screw malposition rate. 18 The o-arm can also be a helpful tool for ilio-sacral screw placement. 19

By comparison, the Artis zeego (Siemens, Germany) is a fixed floor-based, 3D flat-panel C-arm (Fig. 2). Operating rooms with a fixed imaging device are called hybrid operating rooms. Initially developed for vascular and cardiac surgery, the importance of the Artis zeego for orthopaedic surgery is growing. A major benefit of the Artis zeego is the possibility of interdisciplinary use. Different departments can share the high acquisition costs leading to an optimal utilization of the system. 8 In orthopaedic trauma care, this system can also be used for a large variety of indications. Cancienne et al proved its feasibility for ankle surgery. 20 The main indications remain spinal and pelvic fractures. A complete pelvis can be visualized with a single 3D scan (Fig. 3). This can be an essential help during fracture reduction and implantation of ilio-sacral or trans-iliac trans-sacral screws. In combination with a navigation system (BrainLab Curve, BrainLab, Germany), we demonstrated that implantation accuracy was significantly increased compared with standard 3D navigation. 7

Fig. 2
Fig. 2

Hybrid operating room - floor-based 3D flat-panel detector with cone-beam CT capability and fully integrated navigation system.

Citation: EFORT Open Reviews 3, 5; 10.1302/2058-5241.3.170055

Fig. 3
Fig. 3

Large 3D-volume - an entire pelvis can be visualized with a single scan.

Citation: EFORT Open Reviews 3, 5; 10.1302/2058-5241.3.170055

Intra-operative fan beam computed tomography

Since the 1990s, CT has been used for orthopaedic trauma procedures. In the beginning, the operating team had to join the radiologist in a conventional CT facility, which was not designed for open surgery. 21 Only minimally invasive interventions, preferably of the pelvis, could be performed. The accuracy of the implanted screws was high and a CT scanner could also be combined with a navigation system. 22 Even though the image quality and screw accuracy were compelling, many surgeons stopped working with these systems because of the cumbersome setting and the development of mobile 3D C-arms. 23 In recent years there was a revival of CT technology in operating rooms. Fixed and mobile systems are available.

Fixed systems are typically placed on a sliding gantry. Thereby the CT scanner can be parked away from the operating table if not needed. A navigation system can be linked to the CT scanner assuring optimal placement accuracy. 24

Different mobile intra-operative CT scanners were recently introduced. 25,26 Due to their mobility, they are not bound to a specific operating room. However, some of the CT scanners are fixed to the operating table and cannot be used in operating rooms with permanently fixed table columns. Furthermore, there has to be enough room in the operating room for the CT scanner. The Airo (BrainLab, Germany) is automatically combined with a navigation system. The first clinical trials in spine surgery showed promising results. 26,27 The use of intra-operative CT scanners results in high 3D image quality, but in comparison with a cone-beam CT scanner, fluoroscopy is not possible. If fluoroscopy images have to be performed during surgery, an additional C-arm must be provided.

Radiation safety

For some of the mentioned imaging devices, a radiology technician and/or a radiologist are required, mainly depending on the laws of the country in which the system is operated.

With new advances in intra-operative imaging, radiation safety becomes more important. It is mandatory to stand behind a radiation protection wall or to leave the operating room during cone-beam or CT scans; thereby, the exposure of the surgical staff can be eliminated during the scan. Furthermore, a lead apron and thyroid collar should always be worn. Lead goggles can offer additional protection to the eyes. 28 Another option to raise radiation awareness is the use of real-time dosimeters allowing direct visualization of the radiation (Fig. 4).

Fig. 4
Fig. 4

Real-time dosimetry with Raysafe (Unfors Raysafe; Sweden).

Citation: EFORT Open Reviews 3, 5; 10.1302/2058-5241.3.170055

Conclusions

The introduction of flat-panel detectors has led to improvements in intra-operative image quality combined with dose reduction. The possibility of high-quality 3D imaging in combination with navigation can assure optimal implant placement. Due to immediate control of the osteosynthesis, revision surgery at a later time can be prevented. The rapid evolution of intra-operative imaging has just begun. It is important to continuously develop imaging in trauma surgery to ensure that patient and staff safety can be further optimized.

Open access

This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.

ICMJE Conflict of interest statement

F. Gebhard and P. Richter declare honoraria for presentations from Siemens Healthcare, activity outside the submitted work. F. Gebhard declares board membership of AO Foundation, activity outside the submitted work.

Funding statement

The author or one or more of the authors have received or will receive benefits for personal or professional use from a commercial party related directly or indirectly to the subject of this article. In addition, benefits have been or will be directed to a research fund, foundation, educational institution, or other non-profit organization with which one or more of the authors are associated.

References

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    Weis M , Hagelstein C , Diehm T , Schoenberg SO , Neff KW . Comparison of image quality and radiation dose between an image-intensifier system and a newer-generation flat-panel detector system— technical phantom measurements and evaluation of clinical imaging in children. Pediatr Radiol 2016;46:286-92.

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    Cowen AR , Davies AG , Sivananthan MU . The design and imaging characteristics of dynamic, solid-state, flat-panel x-ray image detectors for digital fluoroscopy and fluorography. Clin Radiol 2008;63:1073-85.

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    Richter PH , Gebhard F , Dehner C , Scola A . Accuracy of computer-assisted iliosacral screw placement using a hybrid operating room. Injury 2016;47:402-7.

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    Richter PH , Yarboro S , Kraus M , Gebhard F . One year orthopaedic trauma experience using an advanced interdisciplinary hybrid operating room. Injury 2015;46(suppl 4):S129-34.

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    Richter PH , Grafenberg A , Bodky M , Schmidgunst C , Schwabenland I . [Capability of flat-panel-technology in 2-D/3-D]. OP-Journal 2014;30:169-177. DOI:

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    Richter PH , Steinbrener J , Schicho A , Gebhard F . Does the choice of mobile C-arms lead to a reduction of the intraoperative radiation dose? Injury 2016;47:1608-12.

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    Raj S , Irani FG , Tay KH , Tan BS . C-arm cone beam computed tomography: a new tool in the interventional suite. Ann Acad Med Singapore 2013;42:585-92.

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    Hirota S , Nakao N , Yamamoto S et al.. Cone-beam CT with flat-panel-detector digital angiography system: early experience in abdominal interventional procedures. Cardiovasc Intervent Radiol 2006;29:1034-8.

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    Koyama S , Aoyama T , Oda N , Yamauchi-Kawaura C . Radiation dose evaluation in tomosynthesis and C-arm cone-beam CT examinations with an anthropomorphic phantom. Med Phys 2010;37:4298-306.

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    Kraus M , Fischer E , Gebhard F , Richter PH . Image quality and effective dose of a robotic flat panel 3D C-arm vs computed tomography. Int J Med Robot 2016;12:743-50.

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    Qureshi S , Lu Y , McAnany S , Baird E . Three-dimensional intraoperative imaging modalities in orthopaedic surgery: a narrative review. J Am Acad Orthop Surg 2014;22:800-9.

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    Sullivan JP , Warme BA , Wolf BR . Use of an O-arm intraoperative computed tomography scanner for closed reduction of posterior sternoclavicular dislocations. J Shoulder Elbow Surg 2012;21:e17-e20.

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    Hsu AR , Gross CE , Lee S . Intraoperative O-arm computed tomography evaluation of syndesmotic reduction: case report. Foot Ankle Int 2013;34:753-9.

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    Verma SK , Singh PK , Agrawal D et al.. O-arm with navigation versus C-arm: a review of screw placement over 3 years at a major trauma center. Br J Neurosurg 2016;30:658-61.

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    Kinon MD , Desai R , Loriaux D , Houten JK . Image-guided percutaneous internal fixation of sacral fracture. J Clin Neurosci 2016;23:146-8.

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    Cancienne JM , Crosen MP , Yarboro SR . Use of a hybrid operating room to improve reduction of syndesmotic injuries in ankle fractures: a case report. J Foot Ankle Surg 2016;55:1052-6.

    • PubMed
    • Search Google Scholar
    • Export Citation
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    Gay SB , Sistrom C , Wang GJ et al.. Percutaneous screw fixation of acetabular fractures with CT guidance: preliminary results of a new technique. AJR Am J Roentgenol 1992;158:819-22.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Pieske O , Landersdorfer C , Trumm C et al.. CT-guided sacroiliac percutaneous screw placement in unstable posterior pelvic ring injuries: accuracy of screw position, injury reduction and complications in 71 patients with 136 screws. Injury 2015;46:333-9.

    • PubMed
    • Search Google Scholar
    • Export Citation
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    Yarboro SR , Richter PH , Kahler DM . [The evolution of 3D imaging in orthopedic trauma care. German version]. Unfallchirurg 2016;119:811-6.

  • 24.

    Peng KT , Li YY , Hsu WH et al.. Intraoperative computed tomography with integrated navigation in percutaneous iliosacral screwing. Injury 2013;44:203-8.

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    Barsa P , Frőhlich R , Šercl M , Buchvald P , Suchomel P . The intraoperative portable CT scanner-based spinal navigation: a viable option for instrumentation in the region of cervico-thoracic junction. Eur Spine J 2016;25:1643-50.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Hecht N , Kamphuis M , Czabanka M et al.. Accuracy and workflow of navigated spinal instrumentation with the mobile AIRO(®) CT scanner. Eur Spine J 2016;25:716-23.

  • 27.

    Czabanka M , Haemmerli J , Hecht N et al.. Spinal navigation for posterior instrumentation of C1-2 instability using a mobile intraoperative CT scanner. J Neurosurg Spine 2017;27:268-75.

    • PubMed
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    Matityahu A , Duffy RK , Goldhahn S et al.. The Great Unknown-A systematic literature review about risk associated with intraoperative imaging during orthopaedic surgeries. Injury 2017;48:1727-34.

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    • Export Citation

 

  • Collapse
  • Expand
  • Fig. 1

    Mobile flat-panel detector with large source to image distance.

  • Fig. 2

    Hybrid operating room - floor-based 3D flat-panel detector with cone-beam CT capability and fully integrated navigation system.

  • Fig. 3

    Large 3D-volume - an entire pelvis can be visualized with a single scan.

  • Fig. 4

    Real-time dosimetry with Raysafe (Unfors Raysafe; Sweden).

  • 1.

    Cowen AR , Kengyelics SM , Davies AG . Solid-state, flat-panel, digital radiography detectors and their physical imaging characteristics. Clin Radiol 2008;63:487-98.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Weis M , Hagelstein C , Diehm T , Schoenberg SO , Neff KW . Comparison of image quality and radiation dose between an image-intensifier system and a newer-generation flat-panel detector system— technical phantom measurements and evaluation of clinical imaging in children. Pediatr Radiol 2016;46:286-92.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Seibert JA . Flat-panel detectors: how much better are they? Pediatr Radiol 2006;36(S2):173-81.

  • 4.

    Cowen AR , Davies AG , Sivananthan MU . The design and imaging characteristics of dynamic, solid-state, flat-panel x-ray image detectors for digital fluoroscopy and fluorography. Clin Radiol 2008;63:1073-85.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Krettek C , Gebhard F . [Development of intraoperative C-arm imaging in trauma surgery]. Unfallchirurg 2012;115:100-6.

  • 6.

    Guillou M , Maurel B , Necib H et al.. Comparison of radiation exposure during endovascular treatment of peripheral arterial disease with flat-panel detectors on mobile C-arm vs. fixed systems. Ann Vasc Surg 2018;47:104-13.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Richter PH , Gebhard F , Dehner C , Scola A . Accuracy of computer-assisted iliosacral screw placement using a hybrid operating room. Injury 2016;47:402-7.

  • 8.

    Richter PH , Yarboro S , Kraus M , Gebhard F . One year orthopaedic trauma experience using an advanced interdisciplinary hybrid operating room. Injury 2015;46(suppl 4):S129-34.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Richter PH , Grafenberg A , Bodky M , Schmidgunst C , Schwabenland I . [Capability of flat-panel-technology in 2-D/3-D]. OP-Journal 2014;30:169-177. DOI:

  • 10.

    Richter PH , Steinbrener J , Schicho A , Gebhard F . Does the choice of mobile C-arms lead to a reduction of the intraoperative radiation dose? Injury 2016;47:1608-12.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11.

    Raj S , Irani FG , Tay KH , Tan BS . C-arm cone beam computed tomography: a new tool in the interventional suite. Ann Acad Med Singapore 2013;42:585-92.

  • 12.

    Hirota S , Nakao N , Yamamoto S et al.. Cone-beam CT with flat-panel-detector digital angiography system: early experience in abdominal interventional procedures. Cardiovasc Intervent Radiol 2006;29:1034-8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Koyama S , Aoyama T , Oda N , Yamauchi-Kawaura C . Radiation dose evaluation in tomosynthesis and C-arm cone-beam CT examinations with an anthropomorphic phantom. Med Phys 2010;37:4298-306.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Kraus M , Fischer E , Gebhard F , Richter PH . Image quality and effective dose of a robotic flat panel 3D C-arm vs computed tomography. Int J Med Robot 2016;12:743-50.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Qureshi S , Lu Y , McAnany S , Baird E . Three-dimensional intraoperative imaging modalities in orthopaedic surgery: a narrative review. J Am Acad Orthop Surg 2014;22:800-9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Sullivan JP , Warme BA , Wolf BR . Use of an O-arm intraoperative computed tomography scanner for closed reduction of posterior sternoclavicular dislocations. J Shoulder Elbow Surg 2012;21:e17-e20.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Hsu AR , Gross CE , Lee S . Intraoperative O-arm computed tomography evaluation of syndesmotic reduction: case report. Foot Ankle Int 2013;34:753-9.

  • 18.

    Verma SK , Singh PK , Agrawal D et al.. O-arm with navigation versus C-arm: a review of screw placement over 3 years at a major trauma center. Br J Neurosurg 2016;30:658-61.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Kinon MD , Desai R , Loriaux D , Houten JK . Image-guided percutaneous internal fixation of sacral fracture. J Clin Neurosci 2016;23:146-8.

  • 20.

    Cancienne JM , Crosen MP , Yarboro SR . Use of a hybrid operating room to improve reduction of syndesmotic injuries in ankle fractures: a case report. J Foot Ankle Surg 2016;55:1052-6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Gay SB , Sistrom C , Wang GJ et al.. Percutaneous screw fixation of acetabular fractures with CT guidance: preliminary results of a new technique. AJR Am J Roentgenol 1992;158:819-22.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Pieske O , Landersdorfer C , Trumm C et al.. CT-guided sacroiliac percutaneous screw placement in unstable posterior pelvic ring injuries: accuracy of screw position, injury reduction and complications in 71 patients with 136 screws. Injury 2015;46:333-9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23.

    Yarboro SR , Richter PH , Kahler DM . [The evolution of 3D imaging in orthopedic trauma care. German version]. Unfallchirurg 2016;119:811-6.

  • 24.

    Peng KT , Li YY , Hsu WH et al.. Intraoperative computed tomography with integrated navigation in percutaneous iliosacral screwing. Injury 2013;44:203-8.

  • 25.

    Barsa P , Frőhlich R , Šercl M , Buchvald P , Suchomel P . The intraoperative portable CT scanner-based spinal navigation: a viable option for instrumentation in the region of cervico-thoracic junction. Eur Spine J 2016;25:1643-50.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Hecht N , Kamphuis M , Czabanka M et al.. Accuracy and workflow of navigated spinal instrumentation with the mobile AIRO(®) CT scanner. Eur Spine J 2016;25:716-23.

  • 27.

    Czabanka M , Haemmerli J , Hecht N et al.. Spinal navigation for posterior instrumentation of C1-2 instability using a mobile intraoperative CT scanner. J Neurosurg Spine 2017;27:268-75.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Matityahu A , Duffy RK , Goldhahn S et al.. The Great Unknown-A systematic literature review about risk associated with intraoperative imaging during orthopaedic surgeries. Injury 2017;48:1727-34.

    • PubMed
    • Search Google Scholar
    • Export Citation