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Pengqiang Lou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Guangzhi Zhou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Bo Wei Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Xiaolei Deng Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Decai Hou Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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autophagy induction and NADPH maintenance: new implications for osteonecrosis treatment? Cellular Signalling 2014 26 1 – 8 . ( https://doi.org/10.1016/j.cellsig.2013.08.046 ) 64. Wang XY Gong LJ Huang JM Jiang C & Yan ZQ . Pinocembrin

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Benjamín Cancino Universidad Austral de Chile, Valdivia, Chile

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Matías Sepúlveda Universidad Austral de Chile, Valdivia, Chile
Hospital Base de Valdivia, Valdivia, Chile

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Estefanía Birrer Hospital Base de Valdivia, Valdivia, Chile
Universidad Austral de Chile, Valdivia, Chile

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substantial influence on therapeutic decisions. 25 It can reveal hidden fractures, and it can be used to assess premature physis closure and injury of the articular cartilage, ligaments, and tendons. It can also be used to identify the cause of persistent

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Bruno Direito-Santos Orthopaedic Surgery Department, Hospital de Braga, Portugal
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal

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Guilherme França Orthopaedic Surgery Department, Hospital de Braga, Portugal

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Jóni Nunes Orthopaedic Surgery Department, Hospital de Braga, Portugal

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André Costa Orthopaedic Surgery Department, Hospital de Braga, Portugal

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Eurico Bandeira Rodrigues Orthopaedic Surgery Department, Hospital de Braga, Portugal

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A. Pedro Silva Orthopaedic Surgery Department, Hospital de Braga, Portugal

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Pedro Varanda Orthopaedic Surgery Department, Hospital de Braga, Portugal
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal

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(acetabular retroversion: AR). 9 Changes in acetabular orientation and failure to recognize them may have implications for the final FAI treatment outcome. 10 Moreover, acetabular orientation anomalies could coexist with other important deformities

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Philipp Schleicher Zentrum für Wirbelsäulenchirurgie und Neurotraumatologie, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Germany

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Andreas Pingel Zentrum für Wirbelsäulenchirurgie und Neurotraumatologie, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Germany

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Frank Kandziora Zentrum für Wirbelsäulenchirurgie und Neurotraumatologie, Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Germany

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experienced physician only. A static flexion/extension radiograph without passive guidance by a physician is not recommended due to proven lack of therapeutic consequences. 24 Vascular imaging including CT- and MR-angiography The anatomical

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Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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B Chisari E et al. The role of Wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine . BioMed Res Int 2018 ; 2018 : 7402947 . 26. Filardo G Kon

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Jean-Charles Le Huec Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Stephane Bourret Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Wendy Thompson Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Christian Daulouede Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Thibault Cloché Polyclinique Bordeaux Nord Aquitaine, Bordeaux Univ, 33 300 Bordeaux, France

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Introduction The sacro-iliac joint (SIJ) is a strong load-bearing joint that forms part of the pelvic ring with a very low range of motion that varies during life. Its implication in low back pain was not well established before the

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Djandan Tadum Arthur Vithran Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Anko Elijah Essien Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Masoud Rahmati Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran

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Michael Opoku Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Dong Keon Yon Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea

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Guillermo F López Sánchez Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain

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Ai Koyanagi Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain

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Lee Smith Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK

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Jae Il Shin Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea

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Wenfeng Xiao Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Shuguang Liu Department of Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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Yusheng Li Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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advancements in therapeutic options, fractures remain alarmingly prevalent among those with PMO, particularly in areas rich in trabecular bone like the lumbar spine and femoral neck. Fractures at critical sites, such as the hip, carry significant morbidity and

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Xiaofeng Deng Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haoran Xu Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiaoxia Hao Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Jiawei Liu Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xingru Shang Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Tao Xu Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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7. Coryell PR Diekman BO Loeser RF . Mechanisms and therapeutic implications of cellular senescence in osteoarthritis . Nature Reviews. Rheumatology 2021 17 47 – 57 . ( https://doi.org/10.1038/s41584-020-00533-7 ) 33208917 8. van den Bosch

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Minghe Yao West China School of Medicine, Sichuan University, Chengdu, China

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Tingkui Wu Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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Beiyu Wang Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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their function in the coculture system ( 19 , 20 , 21 , 22 ), indicating another possible mechanism of MSC’s therapeutic effect. The relevance between inflammation and disc degeneration was suggested by increasing proof ( 23 , 24 , 25 ), while MSCs

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Julien Favre Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

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Brigitte M. Jolles Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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contributing to the burden of knee OA is the absence of a cure. Current therapeutic options consist primarily of medication and rehabilitation to reduce symptoms, and of arthroplasty later in the disease, when the joint becomes too severely damaged

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