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autophagy induction and NADPH maintenance: new implications for osteonecrosis treatment? Cellular Signalling 2014 26 1 – 8 . ( https://doi.org/10.1016/j.cellsig.2013.08.046 ) 64. Wang XY Gong LJ Huang JM Jiang C & Yan ZQ . Pinocembrin
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Hospital Base de Valdivia, Valdivia, Chile
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substantial influence on therapeutic decisions. 25 It can reveal hidden fractures, and it can be used to assess premature physis closure and injury of the articular cartilage, ligaments, and tendons. It can also be used to identify the cause of persistent
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Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal
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(acetabular retroversion: AR). 9 Changes in acetabular orientation and failure to recognize them may have implications for the final FAI treatment outcome. 10 Moreover, acetabular orientation anomalies could coexist with other important deformities
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experienced physician only. A static flexion/extension radiograph without passive guidance by a physician is not recommended due to proven lack of therapeutic consequences. 24 Vascular imaging including CT- and MR-angiography The anatomical
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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First Moscow State Medical University – Sechenov University, Moscow, Russia
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IRCCS Humanitas Research Hospital, Milan, Italy
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B Chisari E et al. The role of Wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine . BioMed Res Int 2018 ; 2018 : 7402947 . 26. Filardo G Kon
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Introduction The sacro-iliac joint (SIJ) is a strong load-bearing joint that forms part of the pelvic ring with a very low range of motion that varies during life. Its implication in low back pain was not well established before the
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Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
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Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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advancements in therapeutic options, fractures remain alarmingly prevalent among those with PMO, particularly in areas rich in trabecular bone like the lumbar spine and femoral neck. Fractures at critical sites, such as the hip, carry significant morbidity and
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7. Coryell PR Diekman BO Loeser RF . Mechanisms and therapeutic implications of cellular senescence in osteoarthritis . Nature Reviews. Rheumatology 2021 17 47 – 57 . ( https://doi.org/10.1038/s41584-020-00533-7 ) 33208917 8. van den Bosch
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their function in the coculture system ( 19 , 20 , 21 , 22 ), indicating another possible mechanism of MSC’s therapeutic effect. The relevance between inflammation and disc degeneration was suggested by increasing proof ( 23 , 24 , 25 ), while MSCs
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Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
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contributing to the burden of knee OA is the absence of a cure. Current therapeutic options consist primarily of medication and rehabilitation to reduce symptoms, and of arthroplasty later in the disease, when the joint becomes too severely damaged