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Low-dose dexamethasone during arthroplasty

What do we know about the risks?

Jessica T. Wegener Department of Anesthesiology, Academic Medical Center (AMC), University of Amsterdam, The Netherlands

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Tim Kraal Department of Orthopedic Surgery, Academic Medical Center and the Orthopedic Research Center Amsterdam, The Netherlands

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Markus F. Stevens Department of Anesthesiology, Academic Medical Center (AMC), University of Amsterdam, The Netherlands

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Markus W. Hollmann Department of Anesthesiology, Academic Medical Center (AMC), University of Amsterdam, The Netherlands

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Gino M.M.J. Kerkhoffs Department of Orthopedic Surgery, Academic Medical Center and the Orthopedic Research Center Amsterdam, The Netherlands

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Daniël Haverkamp Department of Orthopedic Surgery, Slotervaart Ziekenhuis, Amsterdam, The Netherlands

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substantial part of the shortened hospital stay is related to improved peri-operative pain management and prevention of post-operative nausea and vomiting (PONV), resulting in faster mobilisation and discharge of patients. Meanwhile, many peri-operative

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Torben Bæk Hansen Aarhus University and The Lundback Centre for Hip and Knee Arthroplasty, Denmark

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general weakness were the main clinical reasons for being hospitalised 24 hours and 48 hours post-operatively after THA and TKA, while nausea, vomiting, confusion and sedation delayed discharge to a minimal extent. Waiting for blood transfusion, for start

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Fabio A. Rodriguez-Patarroyo Outcomes Research Department, Anesthesiology Institute, Cleveland Clinic Ohio, USA

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Nadin Cuello Department of Orthopaedic and Trauma Surgery, Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina

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Robert Molloy Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, USA

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Viktor Krebs Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, USA

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Alparslan Turan Outcomes Research Department, Anesthesiology Institute, Cleveland Clinic Ohio, USA
Department of Anesthesiology, Cleveland Clinic, Cleveland, Ohio, USA

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Nicolas S. Piuzzi Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, USA

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been used in TKA. GA, historically, has been associated to high rates of postoperative nausea, vomit and delirium. 8 On the other hand, neuroaxial anesthesia reduces nausea, vomiting, cardiovascular and pulmonary complications and overall mortality

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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. Patients should not show signs of delirium, nausea or vomiting; they must be able to evacuate (urinate) and maintain their vital signs without the need for intravenous fluids or oxygen. Upon hospital discharge, patients will be provided with oral

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Felix Christoph Finger BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Steffen Schröter Diakonie Klinikum Jung-Stilling GmbH, Department of Trauma and Reconstructive Surgery, Siegen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany

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Christoph Ihle BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Moritz Herbst BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Tina Histing BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Marc-Daniel Ahrend BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany
AO Research Institute Davos, Davos, Switzerland

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following medial open-wedge HTO ( 17 ). To prevent PONV (postoperative nausea and vomiting), all patients received 4 mg dexamethasone. Pehora et al. showed in their Cochrane Review, that Dexamethasone administration can prolong the duration of

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J R W Crutsen Department of Orthopaedic Surgery, VieCuri Medical Center, Venlo, the Netherlands

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M C Koper Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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J Jelsma Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands

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M Heymans Zuyderland Academy, Centre of Knowledge and Information (KIC), Zuyderland Medical Centre, Sittard-Geleen, the Netherlands

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I C Heyligers Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Health Professions Education (SHE), Maastricht University, Maastricht, the Netherlands

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B Grimm Luxembourg Institute Health, Human Motion, Orthopaedics, Sports Medicine, Digital Methods (HOSD), Luxembourg, Luxembourg

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N M C Mathijssen Department of Orthopaedic Surgery, Reinier HAGA Orthopaedic Center, Zoetermeer, the Netherlands

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M G M Schotanus Department of Orthopaedic Surgery and Traumatology, Zuyderland Medical Center, Sittard-Geleen-Heerlen, the Netherlands
School of Care and Public Health Research Institute (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands

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(e.g. tinnitus, vertigo, deafness, blindness, convulsions, headaches and peripheral neuropathy), cardiotoxicity and thyroid toxicity ( 14 ). Nausea, anorexia and unexplained weight loss have also been described ( 6 , 15 , 16 , 17 ). Initially

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Andreas F. Mavrogenis Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis D. Megaloikonomos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Vasileios G. Igoumenou Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Georgios N. Panagopoulos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Efthymia Giannitsioti Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Antonios Papadopoulos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis J. Papagelopoulos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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, tenderness mostly in the thoracolumbar spine and localised back deformity. In addition, cervical spondylodiscitis may cause dysphagia or torticollis. 57 Other non-specific symptoms include malaise, lethargy, confusion, nausea, vomiting, anorexia and

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Nicolò Mosele Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Elisa Pagliarini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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severe complication that may arise if the lesion is located in the cranial bones, especially the skull base, or in the spine, and can be caused by the formation of a fistula. CSF leakage can cause symptoms like headache, vomiting, nausea and cranial

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