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James R. Berstock Musculoskeletal Research Unit, University of Bristol, UK

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James R. Murray Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK

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Michael R. Whitehouse Musculoskeletal Research Unit, University of Bristol, UK

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Ashley W. Blom Musculoskeletal Research Unit, University of Bristol, UK

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Andrew D. Beswick Musculoskeletal Research Unit, University of Bristol, UK

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surgery, tourniquet time, peri-operative blood loss, post-operative pain, days to regain an active straight leg raise and range of movement (ROM) at one week and one year. In addition, data regarding complications such as the incidence of lateral release

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Paulo Diogo Cunha Orthopedic Surgery Department, Hospital de Braga, Portugal

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Tiago P Barbosa Orthopedic Surgery Department, Hospital de Braga, Portugal

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Guilherme Correia Orthopedic Surgery Department, Hospital de Braga, Portugal

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Rafaela Silva Anesthesiology Department, Hospital de Braga, Portugal

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Nuno Cruz Oliveira Orthopedic Surgery Department, Hospital de Braga, Portugal

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Pedro Varanda Orthopedic Surgery Department, Hospital de Braga, Portugal
Life and Health Science Research Institute, University of Minho, Portugal

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Bruno Direito-Santos Orthopedic Surgery Department, Hospital de Braga, Portugal
Life and Health Science Research Institute, University of Minho, Portugal

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pressure points ( 1 ). It is important for the safety of the patient that the entire surgical team knows how to best position the patient on the surgical table and recognize perioperative signs of complications. Although rare, perioperative visual loss

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Andreas Fontalis Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, UK
Academic Unit of Bone Metabolism, University of Sheffield Medical School, Sheffield, UK

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Eustathios Kenanidis Academic Orthopaedic Unit, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece

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Katharine Bennett-Brown Chelsea and Westminster Hospital NHS Foundation Trust, Chelsea, London, UK

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Eleftherios Tsiridis Academic Orthopaedic Unit, Aristotle University Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI), Aristotle University of Thessaloniki, Thessaloniki, Greece

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Introduction Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta in the midbrain. 1 The clinical manifestations can often be insidious and

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E Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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Carlos Kalbakdij-Sánchez Department of Orthopaedic Surgery, Emirates Specialty Hospital, Dubai Healthcare City, Dubai, UAE

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of Knee Society Score (KSS), pain score (VAS – visual analogue scale), Knee Society Function Score (KSFS), or range of movement (ROM). The KSS score improved in both groups postoperatively, with no significant difference between groups ( P   = 0

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xuelei Zhang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chengxin Xie Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Department of Endocrinology, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Luxia Wu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Guoping Cai Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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reduces perioperative bleeding and allogeneic blood transfusion and can be administered orally, intravenously, or topically to achieve hemostasis ( 3 , 4 , 5 ). Clinically, an intravenous drip is usually used. However, administering TXA via the

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Vasileios F Pegios Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eustathios Kenanidis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Stavros Tsotsolis Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece
Department of Trauma and Orthopaedics, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Michael Potoupnis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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Eleftherios Tsiridis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Thessaloniki, Greece

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long postoperative term. AL is the failure of a noninfected prosthesis due to the loss of implant fixation over time ( 7 , 8 ). Insufficient primary fixation and particle-induced osteolysis around the implant have been implicated. Prosthesis

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Thomas Tampere Department of Orthopaedic Surgery, Ghent University Hospital, Ghent, Belgium

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Matthieu Ollivier Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Christophe Jacquet Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Maxime Fabre-Aubrespy Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Sébastien Parratte Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France
Department of Orthopaedic Surgery, International Knee and Joint Centre, Abu Dhabi, UAE

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demanding as metaphyseal bone loss often limits options for anatomical reconstruction and fixation. Current surgical treatment options, including intramedullary nailing, internal and external fixation, are often complicated by an extended non

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Benedikt Johannes Braun Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Jörg Holstein Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Tobias Fritz Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Nils Thomas Veith Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Steven Herath Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Philipp Mörsdorf Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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Tim Pohlemann Department of Trauma, Hand and Reconstructive Surgery, Saarland University Hospital, Homburg, Germany

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, when compared to healthy 20-year-olds. 10 This is associated with a reduced reserve of endogenous catecholamines, limiting the body’s ability to respond to shock and the challenge of blood loss. Further complicating volume response is the fact that

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E. Carlos Rodríguez-Merchán Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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Hortensia De la Corte-Rodríguez Department of Physical and Rehabilitation Medicine, La Paz University Hospital, Madrid, Spain

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Carlos A. Encinas-Ullán Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Primitivo Gómez-Cardero Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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post injury; and early mobilization of the knee after MLKI surgery results in less loss of joint mobility. 2 The timing of surgical reconstruction of MLKIs should be individualized. The approach should take into consideration which ligaments are

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Felix Christoph Finger BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Steffen Schröter Diakonie Klinikum Jung-Stilling GmbH, Department of Trauma and Reconstructive Surgery, Siegen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany

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Christoph Ihle BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Moritz Herbst BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Tina Histing BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Marc-Daniel Ahrend BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany
AO Research Institute Davos, Davos, Switzerland

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were assigned to the thematic groups shown in Fig. 1 and summarized subsequently. Results Perioperative management Support of cartilage cell regeneration It is the aim of knee osteotomies to change the pressure distribution in the knee

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