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Xinhui Wu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Xiaoxin Fang Department of Endocrinology and Metabolism, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China

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Feng Lu Nanjing Medical University, Jiangning, Nanjing, China

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Qiong Chen Jinhua TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

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Junjian Liu Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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Longpo Zheng Department of Orthopedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

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). Over the past decade, ferroptosis has been shown to have great therapeutic potential for many diseases, including drug-resistant cancers, ischemic organ injuries, and other degenerative diseases like osteoporosis (OP). The results of existing literature

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Sakae Tanaka Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

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Introduction Osteoporosis is a serious health concern in the global community. In aged societies such as Japan and Italy, an increasing number of people are suffering from osteoporosis and osteoporotic fractures such as vertebral fractures and

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Jennette Higgs Food to Fit Ltd., PO Box 6057, Greens Norton, Northamptonshire, NN12 8GG, United Kingdom

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Emma Derbyshire Nutritional Insight Ltd., Surrey, KT17 2AA, United Kingdom

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Kathryn Styles Food to Fit Ltd., PO Box 6057, Greens Norton, Northamptonshire, NN12 8GG, United Kingdom

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Introduction Osteoporosis is a silent but progressive disease affecting the density and quality of bone while greatly increasing fracture risk. 1 Globally, around one in three women and one in five men are at risk of an osteoporotic

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Jean-Charles Aurégan Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.
Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.
Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Catherine Bosser Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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Morad Bensidhoum Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.

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Thierry Bégué Department of Orthopaedic, Trauma and Reconstructive Surgery, Antoine Béclère Hospital, AP-HP, Paris Sud University, France.

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Thierry Hoc Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.

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Introduction Osteoporosis is a systemic condition associating a reduction of bone mass and a modification of bone micro-architecture. It leads to a mechanical fragility and a higher risk of fracture. 1 The exact pathophysiology of

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Stefan Rammelt University Center of Orthopaedics & Traumatology, University Hospital Carl Gustav Carus, Dresden, Germany

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article will discuss current treatment approaches to ankle fractures in elderly patients with specific reference to frequent and relevant comorbidities such as diabetes and osteoporosis. Diabetes mellitus Diabetes affects wound and fracture healing

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Markus A. Küper BG Trauma Center, Department for Traumatology and Reconstructive Surgery, Eberhard Karls University, Tübingen, Germany

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Alexander Trulson BG Trauma Center, Department for Traumatology and Reconstructive Surgery, Eberhard Karls University, Tübingen, Germany

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Fabian M. Stuby BG Trauma Center, Department for Traumatology, Orthopedics and Surgery, Murnau am Staffelsee, Germany

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Ulrich Stöckle BG Trauma Center, Department for Traumatology and Reconstructive Surgery, Eberhard Karls University, Tübingen, Germany

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. 11 In particular, female patients over 80 years sustain pelvic ring injuries, with low-energy impact as the main cause of these injuries. Osteoporosis is the most important risk factor for pelvic ring fractures. 12 – 14 It has been shown that

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Morten Schultz Larsen Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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Hagen Schmal Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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Introduction The introduction of bisphosphonates into osteoporosis therapy was a great breakthrough, leading to a remarkable reduction of fracture incidence and improvement of prognosis. 1 Since the effect is caused by a reduction of bone

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Patrick Ziegler BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany
Department of Orthopaedics and Trauma Surgery, Klinik Gut, St. Moritz, Switzerland

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Christian Bahrs Schön Klinik Neustadt, Neustadt in Holstein, Germany

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Christian Konrads Department of Orthopaedic Surgery, University of Tübingen, Tübingen, Germany

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Philipp Hemmann BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Marc-Daniel Ahrend BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany
AO Research Institute Davos, Davos Switzerland

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accepted. However, optimal treatment for geriatric fractures remains controversial. Geriatric patients are particularly at risk of poor outcomes following ankle fractures due to frequent multimorbidity, poor peripheral blood supply and osteoporosis ( 6 , 7

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Djandan Tadum Arthur Vithran Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Anko Elijah Essien Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Masoud Rahmati Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France
Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran

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Michael Opoku Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China

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Dong Keon Yon Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea
Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea

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Guillermo F López Sánchez Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain

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Ai Koyanagi Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain

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Lee Smith Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK

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Jae Il Shin Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea

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Wenfeng Xiao Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Shuguang Liu Department of Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China

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Yusheng Li Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

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Introduction Osteoporosis is a critical global health issue, disproportionately affecting postmenopausal women by leading to diminished bone mass, compromised bone strength, and an elevated risk of fractures. The World Health Organization

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Thomas Tampere Department of Orthopaedic Surgery, Ghent University Hospital, Ghent, Belgium

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Matthieu Ollivier Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Christophe Jacquet Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Maxime Fabre-Aubrespy Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France

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Sébastien Parratte Institute for Locomotion, Aix-Marseille University, St. Marguerite Hospital, Marseille, France
Department of Orthopaedic Surgery, International Knee and Joint Centre, Abu Dhabi, UAE

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-weight-bearing period, malunion or non-union. 2 , 3 Due to the presence of multiple risk factors such as old age, concomitant diseases and osteoporosis, in combination with severe comminution and initial displacement, loss of reduction is described in up to 30

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