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Introduction Orthobiologics are biological substances that are used therapeutically for their positive effects on healing skeletal and soft-tissue injuries. The use of such biological agents in the field of orthopaedic surgery has been drawing
Sengkang General Hospital, Singapore
Joint first authors
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orthobiologic treatment options. There are many treatment modalities that now fit this overarching label. These include (in order of appearance over recent decades) whole blood therapy, traditional prolotherapy, platelet-rich plasma (PRP), bone marrow aspirate
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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summary of promising therapeutic approaches that have, in our opinion, the potential to get approval within the next years. The global market revenue of orthobiologics is estimated to grow from 6.2 billion USD in 2022 to 10.3 billion USD in 2031 ( 35
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Faculty of Medicine Siriraj Hospital, Mahidol University
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The Steadman Clinic, Vail, Colorado, USA
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The Steadman Clinic, Vail, Colorado, USA
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While functional reconstruction of massive irreparable rotator cuff tears remains a challenge, current techniques aimed at recentering and preventing superior migration of the humeral head allow for clinical and biomechanical improvements in shoulder pain and function.
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Recentering of the glenohumeral joint reduces the moment arm and helps the deltoid to recruit more fibers, which compensates for insufficient rotator cuff function and reduces joint pressure.
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In the past, the concept of a superior capsular reconstruction with a patch secured by suture anchors has been used.
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However, several innovative arthroscopic treatment options have also been developed.
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The purpose of this article is to present an overview of new strategies and surgical techniques and if existing present initial clinical results.
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Techniques that will be covered include rerouting the long head of the biceps tendon, utilization of the biceps tendon as an autograft to reconstruct the superior capsule, utilization of a semitendinosus tendon allograft to reconstruct the superior capsule, superior capsular reconstruction with dermal allografts, and subacromial spacers.
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cells. Biological bone graft techniques The concept of ‘orthobiologics’ has been popularized for the biological solutions in orthopaedics, and bone grafting has benefited from different ways to incorporate cells and their secretome, composed of
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. Restore orthobiologic implant: not recommended for augmentation of rotator cuff repairs . J Bone Joint Surg Am 2007 ; 89 : 786 – 791 . 19. American Academy of Orthopaedic Surgeons . Optimizing the management of rotator cuff problems
Department of Orthopaedics and Traumatology, Freiburg University Hospital, Freiburg, Germany.
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-shell biphasic bioactive ceramic microspheres . Sci Rep 2018 ; 8 : 3385 . 50. Calcei JG Rodeo SA . Orthobiologics for bone healing . Clin Sports Med 2019 ; 38 : 79 – 95 . 51. Murahashi Y Yano F
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Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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spectrum of effects ranging from detrimental to disease-modifying: A systematic review of preclinical evidence by the ESSKA Orthobiologic Initiative. Knee Surgery Sports Traumatology Arthroscopy In press. ( https://doi.org/10.1002/ksa.12242 ) 11
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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M & Kon E . Orthobiologic injections for treating degenerative meniscus lesions: a matter of facts? Ten years of clinical experience in a systematic review . Journal of Cartilage & Joint Preservation 2023 3 100104 . ( https://doi.org/10.1016/j
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Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland
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grafts, bone substitutes and orthobiologics: the bridge between basic science and clinical advancements in fracture healing . Organogenesis 2012 8 114 – 124 . ( https://doi.org/10.4161/org.23306 ) 12. Burchardt H . The biology of bone graft repair
