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Joaquim Soares do Brito Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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André Spranger Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Paulo Almeida Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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José Portela Orthopedics Department, University Hospital of Santa Maria, Lisbon, Portugal

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Irene Barrientos-Ruiz Orthopedics Department, University Hospital of La Paz, Madrid

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. Comparison: to compare the functional and oncological results obtained after surgical treatment of distal femur and/or proximal tibia GCTs. Outcomes: local recurrence of the disease; ROM; infection; need for surgical revision; metastatic disease

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Daniel Kotrych Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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Andrzej Bohatyrewicz Department of Orthopedics, Traumatology and Orthopedic Oncology, Pomeranian Medical University, Szczecin, Poland

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Italy

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surgical techniques allows demanding reconstructions ( 19 , 20 , 21 , 22 ). With the use of CAS and custom 3D-printed reconstructions, satisfactory results in terms of functional and oncological outcomes have been also reported in recent series of

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Catalin Cirstoiu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Cretu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Sergiu Iordache Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Mihnea Popa Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Serban Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Adrian Cursaru Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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oncological, radiotherapeutic, and surgical treatment must be determined exactly. Even in the case of a patient with a short life expectancy, the functional outcome following reconstruction resection will be significantly improved, with improvement occurring

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Elisa Pala Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Alberto Procura Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Antonio Berizzi Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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of these conditions are present, an aggressive surgical approach is justified by the evidence of better oncologic outcomes in the mid and long term ( 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ). In most recent years, many patients have been

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Zsombor Panti Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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excision of bone sarcoma is valid if the resection performed achieves oncologic safe margins, clear of any tumour tissue, and the functional results and survival rates expected are equal or better than after an amputation performed for the same case ( Fig

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Thomas Kozak Albany Health Campus, Albany, Australia
Royal Perth Hospital, Perth, Australia

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Stefan Bauer Ensemble Hospitalier de la Côte, Morges, Switzerland

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Gilles Walch Hôpital Privé Jean-Mermoz, Centre Orthopédique Santy, Lyon, France

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Saad Al-karawi Albany Health Campus, Albany, Australia

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William Blakeney Albany Health Campus, Albany, Australia
Royal Perth Hospital, Perth, Australia

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demonstrated decreased pain, improved functional outcome scores and range of motion following revision surgery. Complication rate was reasonably high, with 12 (18%) shoulders requiring repeat revision surgery. Melis et al reported on 37 consecutive anatomical

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Nicolas de l’Escalopier Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France
Service de Chirurgie Orthopédique, Traumatologie et Chirurgie Réparatrice des Membres, Hôpital d’Instruction des Armées Percy, France

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Marjorie Salga Service de médecine physique et réadaptation, Hôpital Raymond Poincaré, France

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Laure Gatin Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France

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François Genêt Service de médecine physique et réadaptation, Hôpital Raymond Poincaré, France

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Philippe Denormandie Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France

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interventions that will lead to positive functional outcomes involves five main points, which will be discussed further. These include: understanding the disease background, pre-operative patient management, the surgical strategy, post-operative care, and the

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Maria A. Smolle Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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Dimosthenis Andreou Department of General Orthopaedics and Tumour Orthopaedics, University Hospital Muenster, Germany

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Per-Ulf Tunn Tumour Orthopaedics, HELIOS Klinikum Berlin-Buch, Germany

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Andreas Leithner Department of Orthopaedics and Trauma, Medical University of Graz, Austria

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, Liang et al compared the functional and oncological outcomes of 62 cases with uncemented tibial fixation and 58 cases with cemented tibial fixation in distal femoral replacement for bone tumours. 29 Osseointegration was observed in 64.3% of patients

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Gerhard M. Hobusch Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Kevin Döring Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Rickard Brånemark Gothenburg University, Gothenburg, Sweden
Biomechatronics Group, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Reinhard Windhager Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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-reported outcome measures (PROMs) blur the boundaries between two aspects of amputation: the best surgical option OR the best possible medical care strategy to improve functional outcome and quality of life after failed surgery for infection, tumours or certain

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Andrea Angelini Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Ivan Bohacek Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Mihovil Plecko Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Carlo Biz Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Mariachiara Cerchiaro Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giuseppe Di Rubbo Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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studies, conservative treatment, curettage and grafting, review articles), or studies not reporting on functional outcomes after surgery. The reviewers independently screened titles and abstracts of all identified studies. Studies were further included in

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