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Keith Tucker Orthopaedic Data Evaluation Panel (ODEP), Norwich, UK

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Klaus-Peter Günther University Centre of Orthopedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

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Per Kjaersgaard-Andersen Department of Orthopaedics, Vejle Hospital, South Danish University, Vejle, Denmark

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Jörg Lützner University Centre of Orthopedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Germany

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Jan Philippe Kretzer Laboratory of Biomechanics and Implant Research, Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Heidelberg, Germany

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Rob G.H.H. Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands

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Toni Lange Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus and Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Germany

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Luigi Zagra IRCCS Istituto Ortopedico Galeazzi, Hip Department, Milan, Italy

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surgeons have the capacity to adapt their practice when they think it is necessary and go ‘off-label’. EFORT consider these issues extremely important; they are all about patient safety which is why they commissioned this appraisal in order to evaluate all

Article Type:
Review Article
Category:
Research
DOI:
https://doi.org/10.1302/2058-5241.6.210080
Volume/Issue:
Volume 6: Issue 11
Open access
Antal Imre Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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Sápi Zoltán Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest

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Szendrői Miklós Department of Orthopaedics, Semmelweis University, Budapest, Hungary

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. They pointed out that denosumab inhibits osteoclast-like giant cells and probably alters the phosphorylation profiles of receptor tyrosine kinases and downstream signalling proteins in the tumourous tissue. Furthermore they performed an off-label

Article Type:
Review Article
Category:
Oncology
DOI:
https://doi.org/10.1530/EOR-23-0138
Volume/Issue:
Volume 8: Issue 12
Open access
Francisco Figueroa Clinica Alemana-Universidad del Desarrollo, Santiago, Chile
Hospital Sotero del Rio, Santiago, Chile

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David Figueroa Clinica Alemana-Universidad del Desarrollo, Santiago, Chile

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Rafael Calvo Clinica Alemana-Universidad del Desarrollo, Santiago, Chile

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Alex Vaisman Clinica Alemana-Universidad del Desarrollo, Santiago, Chile
Hospital Padre Hurtado, Santiago, Chile

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João Espregueira-Mendes Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Portugal; Dom Henrique Research Centre, Portugal; 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Portugal; ICVS/3B’s–PT Government Associate Laboratory, Portugal; Orthopaedics Department of Minho University, Portugal

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Vancomycin presoaked grafts returned to their pre-injury sport compared to their control counterparts. Another important concern are the legal implications involved in this off-label clinical use of Vancomycin. The World Health Organization guideline

Article Type:
Review Article
Category:
Sports & Arthroscopy
DOI:
https://doi.org/10.1302/2058-5241.6.200059
Volume/Issue:
Volume 6: Issue 3
Open access
Önder İ. Kılıçoğlu Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Mehmet Demirel Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Şamil Aktaş Department of Underwater and Hyperbaric Medicine, İstanbul University, Istanbul Faculty of Medicine, Turkey

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The current principles of DFU care are the following: infection management; a rigorous off-loading regimen; local care with several debridement and advanced wound healing methods together with a multidisciplinary approach to assess

Article Type:
Research Article
Category:
Foot & Ankle
DOI:
https://doi.org/10.1302/2058-5241.3.170073
Volume/Issue:
Volume 3: Issue 5
Open access
Sohail Yousaf Kingston Hospital NHS Foundation Trust, UK
University of Brighton, UK

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Edward J.C. Dawe Western Sussex Hospitals NHS Foundation Trust, UK
Brighton and Sussex Medical Schools, UK

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Alan Saleh Kingston Hospital NHS Foundation Trust, UK

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Ian R. Gill Kingston Hospital NHS Foundation Trust, UK

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Alex Wee Frimley Health NHS Foundation Trust, UK

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for detecting active bony pathology, since when a foot is also affected by vascular insufficiency the study may be falsely reassuring. Indium-111-labelled leukocyte scanning results in the highest sensitivity and specificity for osteomyelitis, which is

Article Type:
Research Article
Category:
Foot & Ankle
DOI:
https://doi.org/10.1302/2058-5241.3.180003
Volume/Issue:
Volume 3: Issue 10
Open access
Daniel Bachman University of Missouri-Kansas City, Kansas City, USA

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Akin Cil University of Missouri-Kansas City, Kansas City, USA

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include distal humeral non-union after a failed attempted ORIF. Relatively preserved cartilage on the radial head and proximal ulna is a pre-requisite for the use of elbow HA. Surgeons should be aware that elbow HA for any indication is an off-label use of

Article Type:
Review Article
Category:
Shoulder & Elbow
DOI:
https://doi.org/10.1302/2058-5241.2.160064
Volume/Issue:
Volume 2: Issue 4
Open access
Pierre Hoffmeyer Editor in Chief, EFORT Open Reviews

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This last year of the second decade of the twenty-first century will be remembered as the year of all dangers. Things started off well enough with the usual New Year’s celebrations, all of us looking forward to a bright future full of promises

Article Type:
Editorial
Category:
Research
DOI:
https://doi.org/10.1302/2058-5241.6.211000
Volume/Issue:
Volume 6: Issue 1
Open access
Alan G. Fraser Department of Cardiology, University Hospital of Wales, Cardiff, UK

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Rob G.H.H. Nelissen Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands

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Per Kjærsgaard-Andersen Department of Orthopaedics, Vejle Hospital, South Danish University, Vejle, Denmark

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Piotr Szymański Centre of Postgraduate Medical Education, MSWiA Central Clinical Hospital, Warsaw, Poland

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Tom Melvin Healthcare Products Regulatory Authority, Earlsfort Terrace, Dublin 2, Ireland

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Paul Piscoi Health Technology Unit B6, Directorate General for Health (DG SANTE), European Commission, Brussels, Belgium

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On behalf of the CORE–MD Investigators (see Appendix) Alan Fraser, Piotr Szymański, Chris Gale, Aldo Maggioni, Elisabetta Zanon, Christina Dimopoulou, Cinzia Ceccarelli, Polyxeni Vairami, Anett Ruszanov, Per Kjærsgaard-Andersen, Rob Nelissen, Adrian Ott, Elizabeth Macintyre, Loredana Simulescu, Marieke Meijer, Berthold Koletzko, Sarah Wieczorek, Adamos Hadjipanayis, Stefano Del Torso, Perla Marang-van de Mheen, Lotje Hoogervorst, Ewout W. Steyerberg, Bas Penning De Vries, Peter McCulloch, Martin Landray, Daniel Prieto Alhambra, James Smith, Anne Lubbeke-Wolf, Stefan James, Sergio Buccheri, Robert Byrne, Laurna McGovern, Stephan Windecker, Andre Frenk, Georgios Siontis, Christoph Stettler, Arjola Bano, Lia Bally, Frank E. Rademakers, Jan D‘hooge, Anton Vedder, Elisabetta Biasin, Erik Kamenjasevic, Petra Schnell-Inderst, Felicitas Kühne, Ola Rolfson, Joel Jakobsson, Amanda Tornsö, Enrico G. Caiani, Lorenzo Gianquintieri, Cinzia Cappiello, Maristella Matera, Tom Melvin, Niall MacAleenan, Ria Mahon, Michèle Meagher, Gearóid McGauran, Thomas Wejs Møller, Ann-Sofie Sonne Holm-Schou, Jan Szulc, Robert E. Geertsma, Jantine W.P.M. van Baal, Joëlle M. Hoebert, Susana L.F. Cabaço, Paola Laricchiuta, Marina Torre, Filippo Boniforti, Eugenio Carrani, Stefania Ceccarelli, Claudia Wild, Sabine Ettinger, Juan Antonio Blasco Amaro, Juan Carlos Rejón Parrilla, Agnieszka Dobrzynska, David Epstein, Valentina Strammiello, Hannes Jarke, Kaisa Immonen, Françoise Schlemmer, Sabina Hoekstra, Marianna Mastroroberto, Christoph Ziskoven, Michael Hahn, Erman Melikyan, Richard Holborow, Suzanne Halliday, Alexey Shiryaev, Gero Viola, Harry van Vugt

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-points and mandated post-marketing studies. 36 Most had not been approved for children. 37 Off-label drug use in children is associated with adverse events 38 and risks may also occur from off-label use of devices. In CORE–MD, the evaluation of evidence

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.6.210081
Volume/Issue:
Volume 6: Issue 10
Open access
Pernille Bovbjerg Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark

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Ditte Høgh Department of Orthopedic Surgery, Hospital of Southern Denmark, Odense, Denmark

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Lonnie Froberg Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark

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Hagen Schmal Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark
Clinic of Orthopaedic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Moustapha Kassem Department of Endocrinology, Odense University Hospital, Odense, Denmark

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stimulates bone formation by activating osteoblasts. PTH (1-84) has shown the same effect and has been used as an osteoporotic treatment as well. 5 This suggests a positive influence on bone healing, and teriparatide has been used off-label for treatment

Article Type:
Review Article
Category:
Hip
DOI:
https://doi.org/10.1302/2058-5241.6.200029
Volume/Issue:
Volume 6: Issue 1
Open access
Xiang-Dong Wu Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Yixin Zhou Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Hongyi Shao Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Dejin Yang Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Sheng-Jie Guo Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, China

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Wei Huang Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

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-of-the-art. Of note, the FDA has currently approved robotic-assisted technology for primary joint arthroplasty, including unicompartmental knee arthroplasty (UKA), THA, and TKA; the technique described here represents an off-label indication. This study was not

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-22-0105
Volume/Issue:
Volume 8: Issue 1
Open access