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How to prepare and manage a systematic review and meta-analysis of clinical studies

James R. Berstock University of British Colombia Department of Orthopaedics, Gordon & Leslie Diamond Health Care Centre, Vancouver, British Columbia, Canada

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Michael R. Whitehouse Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol, UK
National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, UK

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studies), thereby directing future research. In this article, we discuss the origins of systematic review and summarize the methodology for performing such work and the meta-analysis which may follow if appropriate data are available. Pioneering work

Article Type:
Review Article
Collections:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.4.180049
Volume/Issue:
Volume 4: Issue 5
Open access

Risk factors for full-thickness rotator cuff tears: a systematic review and meta-analysis

Jinlong Zhao The Second School of Clinical Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou, China

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Jianke Pan The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Province Hospital of Traditional Chinese Medicine), Guangzhou, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou, China

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Ling-feng Zeng The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Province Hospital of Traditional Chinese Medicine), Guangzhou, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou, China

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Ming Wu The Second School of Clinical Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou, China

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Weiyi Yang The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Province Hospital of Traditional Chinese Medicine), Guangzhou, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou, China

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Jun Liu The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Province Hospital of Traditional Chinese Medicine), Guangzhou, China
Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou, China

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used a meta-analysis to quantitatively analyse potential risk factors for full-thickness rotator cuff tears to provide a theoretical basis for clinical treatment and prognosis. Methods This meta-analysis was performed in strict accordance with

Article Type:
Review Article
Collections:
Shoulder & Elbow
DOI:
https://doi.org/10.1302/2058-5241.6.210027
Volume/Issue:
Volume 6: Issue 11
Open access

The efficacy and safety of tranexamic acid in transforaminal lumbar interbody fusion: a systematic review and meta-analysis

Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xueli Yan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Han Zhang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Wenjun Pan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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meta-analysis of 20 RCTs, Liu et al. demonstrated that TXA reduces blood loss, reduces transfusion rates, shortens hospital stay, and does not increase the incidence of postoperative complications in open spine surgery ( 6 ). Qin et al. , in a meta-analysis

Article Type:
Systematic Review
Collections:
Spine
DOI:
https://doi.org/10.1530/EOR-23-0168
Volume/Issue:
Volume 8: Issue 12
Open access

Exchange nailing versus augmentative plating in the treatment of femoral shaft nonunion after intramedullary nailing: a meta-analysis

Hua Luo Fengxian District Central Hospital Graduate Student Training Base, Jinzhou Medical University, Shanghai, China
Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Yongwei Su The First Affiliated Hospital of Jinzhou Medical University, Graduate Student Training Base, Jinzhou Medical University, Jinzhou, China

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Liang Ding Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Haijun Xiao Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Ming Wu Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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Feng Xue Fengxian District Central Hospital Graduate Student Training Base, Jinzhou Medical University, Shanghai, China
Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, China

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treatments have different advantages and disadvantages. Hence, it is necessary to assess the efficiency of different treatments between exchange nailing and augmentative plating based on the available evidence. We considered that this meta-analysis would

Article Type:
Review Article
Collections:
Trauma
DOI:
https://doi.org/10.1302/2058-5241.4.180054
Volume/Issue:
Volume 4: Issue 8
Open access

Intraoperative vancomycin powder to reduce surgical site infections after posterior spine surgery: a systematic review and meta-analysis

Hua Luo Department of Orthopaedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yongwei Su The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China

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Feng Xue Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, People’s Republic of China

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Zhenghua Hong Department of Orthopaedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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powder (VP) spray, local to lower spine SSIs because of its antimicrobial activity on most of the gram-positive bacteria and cost-effectiveness. In addition, many predecessors have performed a meta-analysis to study the relieving effect of vancomycin in

Article Type:
Review Article
Collections:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-21-0077
Volume/Issue:
Volume 7: Issue 2
Open access

Meta-analysis of the clinical efficacy and safety of oblique lateral interbody fusion and transforaminal interbody fusion in the treatment of degenerative lumbar spondylolisthesis

Wen-xi Sun Guangzhou University of Chinese Medicine, Guangzhou, China

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Hao-nan Liu Guangzhou University of Chinese Medicine, Guangzhou, China

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Meng-tong Chen Guangzhou University of Chinese Medicine, Guangzhou, China

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Yong-peng Lin Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China

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Hong-shen Wang Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China

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Bo-lai Chen Guangzhou University of Chinese Medicine, Guangzhou, China
Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China

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increasingly recognized by orthopaedic surgeons. They have gradually become widely used clinical procedures. However, there is still debate as to which of these two techniques is more advantageous ( 6 ). A meta-analysis of the clinical efficacy and safety of

Article Type:
Review Article
Collections:
Spine
DOI:
https://doi.org/10.1530/EOR-22-0042
Volume/Issue:
Volume 7: Issue 9
Open access

Retrograde tibiotalocalcaneal nailing for the treatment of acute ankle fractures in the elderly: a systematic review and meta-analysis

Victor Lu School of Clinical Medicine, University of Cambridge, Cambridge, UK

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Maria Tennyson Department of Trauma and Orthopaedics, Addenbrooke’s Hospital, Cambridge, UK

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Andrew Zhou School of Clinical Medicine, University of Cambridge, Cambridge, UK

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Ravi Patel Department of Trauma and Orthopaedics, Shrewsbury and Telford Hospital NHS Trust, UK

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Mary D Fortune Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

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Azeem Thahir Department of Trauma and Orthopaedics, Addenbrooke’s Hospital, Cambridge, UK

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Matija Krkovic Department of Trauma and Orthopaedics, Addenbrooke’s Hospital, Cambridge, UK

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risk of wound dehiscence or infection ( 9 ). This study aims to provide a comprehensive review with a detailed meta-analysis of the current evidence for using a TTC nail as the primary surgical option to treat fragility ankle fractures in the elderly

Article Type:
Review Article
Collections:
Foot & Ankle
DOI:
https://doi.org/10.1530/EOR-22-0017
Volume/Issue:
Volume 7: Issue 9
Open access

Intraosseous regional prophylactic antibiotics decrease the risk of infection in total knee arthroplasty compared with intravenous antibiotics: a systematic review and meta-analysis

Xinhuan Lei Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Jie Xiang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hailan Yang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hongya Bao Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Zhong Zhu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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incidence of infection compared with that in the control group. Methods This meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement ( 6 ). The protocol for this meta-analysis

Article Type:
Review Article
Collections:
Knee
DOI:
https://doi.org/10.1530/EOR-22-0130
Volume/Issue:
Volume 8: Issue 3
Open access

Reverse total shoulder arthroplasty (RTSA) versus open reduction and internal fixation (ORIF) for displaced three-part or four-part proximal humeral fractures: a systematic review and meta-analysis

Heri Suroto Department of Orthopaedics & Traumatology, Dr. Soetomo General Hospital / Universitas Airlangga, Surabaya, Indonesia
These authors contributed equally to this work

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Brigita De Vega Institute of Orthopaedics and Musculoskeletal Science, University College London, London, UK
Cell & Tissue Bank-Regenerative Medicine Centre, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
These authors contributed equally to this work

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Fani Deapsari Cell & Tissue Bank-Regenerative Medicine Centre, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

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Tabita Prajasari Department of Orthopaedics & Traumatology, Dr. Soetomo General Hospital / Universitas Airlangga, Surabaya, Indonesia

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Pramono Ari Wibowo Department of Orthopaedics & Traumatology, Dr. Soetomo General Hospital / Universitas Airlangga, Surabaya, Indonesia

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Steven K. Samijo Department of Orthopaedics and Traumatology Zuyderland Medisch Centrum, Heerlen, the Netherlands

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fracture configuration or other surgical procedures in which the raw data could not be separated. We also excluded case series, case reports, reviews, systematic reviews, meta-analysis, editorials, letters, book chapters, study protocols, non

Article Type:
Review Article
Collections:
Shoulder & Elbow
DOI:
https://doi.org/10.1302/2058-5241.6.210049
Volume/Issue:
Volume 6: Issue 10
Open access

Biodegradable vs nonbiodegradable suture anchors for rotator cuff repair: a systematic review and meta-analysis

Heri Suroto Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

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Benedictus Anindita Satmoko Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia

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Tabita Prajasari Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

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Brigita De Vega Division of Surgery and Interventional Science, University College London, Royal Free Hospital Campus, United Kingdom

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Teddy Heri Wardhana Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

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Steven K Samijo Department of Orthopedic and Traumatology, Zuyderland Medisch Centrum, Heerlen, Netherlands

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drawbacks ( 12 ). To our knowledge, there is no systematic review and meta-analysis comparing BSA and NBSA for RC repair in the literature. Thus, we aim to compare the clinical outcomes and complications of RC tear repair using BSA and NBSA based on direct

Article Type:
Systematic Review
Collections:
Shoulder & Elbow
DOI:
https://doi.org/10.1530/EOR-23-0012
Volume/Issue:
Volume 8: Issue 10
Open access