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  • mesenchymal stromal cell x
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Minghe Yao West China School of Medicine, Sichuan University, Chengdu, China

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Tingkui Wu Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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Beiyu Wang Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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Introduction Mesenchymal stromal cells (MSCs) are easily accessed self-renewing cells with proliferation potential, multilineage differentiation potency, and immunoregulatory functions ( 1 ). Various cell sources can be used to isolate MSCs

Article Type:
Review Article
Category:
Spine
DOI:
https://doi.org/10.1530/EOR-22-0083
Volume/Issue:
Volume 8: Issue 3
Open access
Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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non-union treatment. Bone autograft is the safest and most effective grafting procedure, since it contains the patient’s mesenchymal stromal cells (MSCs) to enhance osteogenesis and growth factors to enhance osteo-induction, 16 while providing a

Article Type:
Review Article
Category:
Research
DOI:
https://doi.org/10.1302/2058-5241.5.190062
Volume/Issue:
Volume 5: Issue 10
Open access
Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Sven Geissler Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Tazio Maleitzke Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Carsten Perka Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Georg N Duda Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Alexander Hildebrandt Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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-lethal. To increase the chances of regulatory approval, the cost-efficiency needs to be improved and safety profiles established. Cell-based therapies Isolation and characterization of bone marrow-derived mesenchymal-like stromal cells (bMSCs) have

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-24-0084
Volume/Issue:
Volume 9: Issue 9
Open access
Enrique Gómez-Barrena Department of Orthopaedic Surgery and Traumatology, Hospital La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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Christian Ehrnthaller Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Germany

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.1016/j.injury.2021.10.002 ) 64 Fekete N Rojewski MT Lotfi R & Schrezenmeier H . Essential components for ex vivo proliferation of mesenchymal stromal cells . Tissue Engineering. Part C, Methods 2014 20 129 – 139 . ( https://doi.org/10

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-24-0032
Volume/Issue:
Volume 9: Issue 5
Open access
Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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of leukocyte-poor PRP. Note . PRP, platelet-rich plasma. Mesenchymal stem cells (MSCs) MSC treatment consists of intra-articular injections of stem cells associated to a pool of immune-modulatory and anti-inflammatory stromal

Article Type:
Review Article
Category:
Knee
DOI:
https://doi.org/10.1302/2058-5241.6.210026
Volume/Issue:
Volume 6: Issue 6
Open access
Fan Wu Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University (LMU), Munich, Germany

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Michael Nerlich Department of Trauma Surgery, University Regensburg Medical Center, Regensburg, Germany

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Denitsa Docheva Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Center, Regensburg, Germany and Department of Medical Biology, Medical University-Plovdiv, Plovdiv, Bulgaria

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elucidated Kohler at al 30 Bi et al 31 Perivascular cell Pericyte Tendon mesenchymal stem cell (TMSC) Vessel, paratenon, epitenon, tendon sheets Regulation of stem cells; regeneration of various tissues; immunomodulation Tempfer et al

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.2.160075
Volume/Issue:
Volume 2: Issue 7
Open access
Akintunde George Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Marianne Ellis Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Harinderjit Singh Gill Department of Mechanical Engineering, University of Bath, Bath, UK

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with dental implant in canine mandible . PLoS One 2012 ; 7 : e32355 . 58. Potier E Ferreira E Andriamanalijaona R et al. Hypoxia affects mesenchymal stromal cell osteogenic differentiation and angiogenic

Article Type:
Review Article
Category:
Hip
DOI:
https://doi.org/10.1302/2058-5241.4.180030
Volume/Issue:
Volume 4: Issue 9
Open access
Lars Nonnenmacher Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Maximilian Fischer Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Lyubomir Haralambiev Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Sander Bekeschus ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany

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Frank Schulze Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Georgi I Wassilew Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Janosch Schoon Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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Johannes C Reichert Center for Orthopaedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Greifswald, Germany

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). Further, in vitro studies also suggested selective cytotoxicity of indirect CPP treatment in OS cells over mesenchymal stromal cells (MSCs) ( 79 ) and other less malignant cells ( 70 ). As mentioned earlier, it is assumed that the selectivity of CPP on

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-22-0106
Volume/Issue:
Volume 8: Issue 6
Open access
Hsiao-Yi Cheng Department of Primary Care Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Chun-Wei Liang School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

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Yu-Hao Lee Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Timporn Vitoonpong Department of Rehabilitation, King Chulalongkorn Memorial Hospital, Bankok, Thailand

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Chun-De Liao Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan

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Shih-Wei Huang Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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, hyaluronic acids, platelet-rich plasma (PRP), platelet rich in growth factor (PRGF), botulinum toxin A, O 2 –O 3 , dextrose, and mesenchymal stem cell (MSC). Regarding exercise, most studies included resistance training programs to strengthen the quadriceps

Article Type:
Systematic Review
Category:
Knee
DOI:
https://doi.org/10.1530/EOR-23-0136
Volume/Issue:
Volume 9: Issue 7
Open access
Giorgio Maria Calori ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Emilio Mazza ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Alessandra Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Simone Mazzola ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Massimiliano Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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substitute implantation reduces the incidence of fractural stage non-traumatic AVN of the FH. BM, bone morphogenetic; BMMCs, BM containing mononuclear cells; BMP-7, bone morphogenetic protein 7; BMSCs, BM stromal cells or BM-derived mesenchymal

Article Type:
Research Article
Category:
Hip
DOI:
https://doi.org/10.1302/2058-5241.2.150006
Volume/Issue:
Volume 2: Issue 2
Open access