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Fan Wu Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University (LMU), Munich, Germany

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Michael Nerlich Department of Trauma Surgery, University Regensburg Medical Center, Regensburg, Germany

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Denitsa Docheva Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Center, Regensburg, Germany and Department of Medical Biology, Medical University-Plovdiv, Plovdiv, Bulgaria

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elucidated Kohler at al 30 Bi et al 31 Perivascular cell Pericyte Tendon mesenchymal stem cell (TMSC) Vessel, paratenon, epitenon, tendon sheets Regulation of stem cells; regeneration of various tissues; immunomodulation Tempfer et al

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Hsiao-Yi Cheng Department of Primary Care Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Chun-Wei Liang School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

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Yu-Hao Lee Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Timporn Vitoonpong Department of Rehabilitation, King Chulalongkorn Memorial Hospital, Bankok, Thailand

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Chun-De Liao Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan

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Shih-Wei Huang Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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, hyaluronic acids, platelet-rich plasma (PRP), platelet rich in growth factor (PRGF), botulinum toxin A, O 2 –O 3 , dextrose, and mesenchymal stem cell (MSC). Regarding exercise, most studies included resistance training programs to strengthen the quadriceps

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Enrique Gómez-Barrena Department of Orthopaedic Surgery and Traumatology, Hospital La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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Christian Ehrnthaller Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Germany

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( 12 ) and also a decrease in proliferation and differentiation of mesenchymal stem cells (MSCs) ( 13 ), which may suggest a systemic mesenchymal and osteogenic cell pool defect in patients sustaining this type of lesion. Those are the non-unions that

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Luca Pierannunzii Gaetano Pini Orthopedic Institute, Milan, Italy
IRCCS Galeazzi Orthopedic Institute, Milan, Italy

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Luigi Zagra Gaetano Pini Orthopedic Institute, Milan, Italy
IRCCS Galeazzi Orthopedic Institute, Milan, Italy

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is the passive ability of a scaffold to be progressively substituted by viable bone; osteoinductivity is the capacity to stimulate the osteoblastic differentiation of local adult stem cells (i.e. mesenchymal stem cells, MSCs) through specific growth

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Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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products we include corticosteroids (CS), hyaluronic acid (HA), polynucleotides, oxygen-ozone therapy, platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs). CS and HA are ranked first as the most frequently injected substances and their use is

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Mukai Chimutengwende-Gordon Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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James Donaldson Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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George Bentley Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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stimulation is to penetrate the subchondral bone plate with an awl, allowing a fibrin clot containing mesenchymal stem cells to be produced in the defect. 11 The mesenchymal stem cells are able to differentiate into fibrochondrocytes, leading to

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Minghe Yao West China School of Medicine, Sichuan University, Chengdu, China

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Tingkui Wu Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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Beiyu Wang Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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#4 (‘pulposus-derived mesenchymal stem cell’; 88; 2015; S  = 0.879; Sakai & Andersson ( 72 )), the trend came into cluster #3 (‘interventional pain physician’; 126; 2017; S  = 0.807; Noriega et al. ( 43 )) while branching into two related clusters

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Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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the other 76% proposed the use of autologous cells. Treatments included percutaneously aspirated autologous bone marrow cells ( n = 1), pre-osteoblast cells from bone marrow ( n = 2), and mesenchymal stem cells from bone marrow ( n = 9). Two trials

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Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Sven Geissler Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Tazio Maleitzke Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Carsten Perka Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Georg N Duda Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Alexander Hildebrandt Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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E Aggelidou E & Kritis A . Bone regeneration with mesenchymal stem cells in scaffolds: systematic review of human clinical trials . Stem Cell Reviews and Reports 2024 20 938 – 966 . ( https://doi.org/10.1007/s12015-024-10696-5 ) 35

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Akintunde George Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Marianne Ellis Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Harinderjit Singh Gill Department of Mechanical Engineering, University of Bath, Bath, UK

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differentiating along the osteogenic, adipogenic and chondrogenic lineages as previously demonstrated by numerous studies. Potier and Ferreira et al described in their own study that temporary exposure of mesenchymal stem cells to hypoxia leads to limited

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