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A Frodl Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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N Geisteuer Department of Orthopedics and Traumatology, Asklepios Hospital Harburg, Hamburg, Germany

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A Fuchs Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany

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T Nymark Department of Orthopedic Surgery, University Hospital Odense, Odense C, Denmark

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H Schmal Department of Orthopedics and Traumatology, Freiburg University Hospital, Freiburg, Germany
Department of Orthopedic Surgery, University Hospital Odense, Odense C, Denmark

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Introduction Lower extremity amputation bears a high risk for post-surgical wound infections ( 1 ). Multi-morbid patients with diabetes-induced peripheral arterial disease represent the main subjects of major lower limb amputations ( 2 ). A

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Laura Walthert Department of Orthopaedic and Traumatology, CHUV, Lausanne, Switzerland

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Michael Ris Department of Orthopaedic and Traumatology, CHUV, Lausanne, Switzerland

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Kevin Moerenhout Department of Orthopaedic and Traumatology, CHUV, Lausanne, Switzerland

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Sébastien Déglise Department of Vascular Surgery, CHUV, Lausanne, Switzerland

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Pietro Giovanni Di Summa Department of Plastic and Hand Surgery, CHUV, Lausanne, Switzerland

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Sylvain Steinmetz Department of Orthopaedic and Traumatology, CHUV, Lausanne, Switzerland

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Introduction Major amputations of the lower extremity may be required after trauma and variety of underlying diseases such as peripheral vascular disease (PVD), diabetes, and malignancies. The goal of any major amputation is an optimal

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Zsombor Panti Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Introduction The dawn of extremity bone sarcoma management was dominated by amputation as a standard of surgical treatment. Although some attempts were made to perform limb-sparing procedures, by carrying out segmental resection and

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Brijesh Ayyaswamy Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK

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Bilal Saeed Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK

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Anoop Anand Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK

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Lai Chan Edge Hill University, Ormskirk, UK

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Vishwanath Shetty Department of Orthopaedics, Blackpool Teaching Hospitals NHS Trust, Blackpool, UK

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results of all studies. More recent and higher quality data which formed the major pool of cases and compared with controls have shown more positive consistency and direction of effect towards better quality of life after amputation. 25 , 26

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Gerhard M. Hobusch Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Kevin Döring Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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Rickard Brånemark Gothenburg University, Gothenburg, Sweden
Biomechatronics Group, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Reinhard Windhager Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria

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congenital musculoskeletal anomalies. 1 , 14 The main objective of the present review is to identify all major studies dealing with amputation surgery and prosthetic technologies published between 1 January 2014 and 1 October 2019. The specific focus was

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Thekla Antoniadou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Vasilios G. Igoumenou First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Georgios N. Panagopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Leonidas Dimopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Konstantinos G. Moulakakis Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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George S. Sfyroeras Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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Andreas Lazaris Department of Vascular Surgery, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece

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major threats relating to DFU. 1 , 3 , 10 Eradication of the infection is difficult and recurrences are common, leading to purulent ulcers, functional distortion of the foot and the need for amputation. 9 The lifetime risk of diabetic patients

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E. Mascard Necker University Hospital, 75015 Paris, France.

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N. Gaspar Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France

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L. Brugières Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France

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C. Glorion Orthopedic Surgery Department, Necker University Hospital, 149 rue de Sèvres, 75015 Paris, France

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S. Pannier Orthopedic Surgery Department, Necker University Hospital, 149 rue de Sèvres, 75015 Paris, France

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A. Gomez-Brouchet Laboratoire d'anatomie et cytologie pathologiques, Institut Universitaire du Cancer de Toulouse- Oncopole, 1 avenue Irène Joliot-Curie. 31059 Toulouse Cedex 9, France

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these misdiagnosed tumours is the increasing rate of amputation or local recurrences in the involved patients. After the age of 40 years, chondrosarcoma is the most usual malignant tumour of the foot. In bone tumours such as osteosarcoma or Ewing

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Önder İ. Kılıçoğlu Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Mehmet Demirel Department of Orthopaedics and Traumatology, İstanbul University, Istanbul Faculty of Medicine, Turkey

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Şamil Aktaş Department of Underwater and Hyperbaric Medicine, İstanbul University, Istanbul Faculty of Medicine, Turkey

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However, the results of a meta-analysis obtained from pooled data of five trials with 312 patients indicated that there was no significant difference in terms of major amputation rate with HBOT. 49 Nonetheless, a current review strongly emphasized the

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Bogdan Serban Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Adrian Cursaru Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Cornelia Nitipir Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Cristina Orlov-Slavu Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Catalin Cirstoiu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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, especially in cases where major resections or adjuvant treatments are to be proposed. Although most sarcoma treatment centers use MRI to detect local recurrences, it is necessary to confirm the histopathological type before performing surgical resection

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Sohail Yousaf Kingston Hospital NHS Foundation Trust, UK
University of Brighton, UK

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Edward J.C. Dawe Western Sussex Hospitals NHS Foundation Trust, UK
Brighton and Sussex Medical Schools, UK

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Alan Saleh Kingston Hospital NHS Foundation Trust, UK

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Ian R. Gill Kingston Hospital NHS Foundation Trust, UK

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Alex Wee Frimley Health NHS Foundation Trust, UK

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approach has helped to improve the quality of diabetic foot care as well as to reduce the rate of major amputations. 25 , 26 Role of diabetic MDT or foot care teams The National Institute for Health and Care Excellence (NICE) has issued guidance

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