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attributed to musculoskeletal disorders ( 13 ), regeneration therapeutics for intervertebral disc degeneration (IDD) promoted an etiological treatment to stop the continuous degradation of intervertebral disc. A restoration of the spinal anatomy and
Centre for Spinal Surgery, Queens Medical Centre, Nottingham University NHS Trust, Nottingham, UK
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original work is attributed. References 1. Kang JD Stefanovic-Racic M McIntyre LA Georgescu HI Evans CH . Toward a biochemical understanding of human intervertebral disc degeneration and herniation
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consensual definition of ASD is missing. In most studies, ASDeg is defined as radiographic changes in the intervertebral discs adjacent to the surgically treated levels, whereas ASD is defined as the pathologic process associated with disc degeneration
These authors contributed equally to this work and should be considered co-first authors
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These authors contributed equally to this work and should be considered co-first authors
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2 The treatment of certain cervical-spine disorders by anterior removal of the intervertebral disc and interbody fusion Smith, GW 1102 17.5 IV 3 Radiculopathy and myelopathy at segments adjacent to the site of a previous anterior
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bulging, and collapse of the disc space which leads to the narrowing of the space, resulting in an increased transfer of stress to the facet joints. This accelerates facet joint cartilage degeneration and osteophyte formation. 8 , 9 The combination
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Division of Spine Center, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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, but the choice of a surgical method for the treatment of DLS is highly controversial ( 3 ). Transforaminal lumbar interbody fusion (TLIF) completes the removal of the intervertebral disc through the intervertebral foramen to achieve direct
Anatomy Institute and Orthopedics Department, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
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the borders of the intervertebral disc space, allowing for a pressurization of the adjacent intervertebral discs closer to the physiological, and thus minimizing its accelerated degeneration, loss of effective load-damping function and the early onset
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contributors to slip progression, including a lower intercristal line ( Fig. 2 ), 7 tilting of the intervertebral disc, 4 tropism and sagittal orientation of the facet joints ( Figs 3 and 4 ), 8 increased pelvic incidence, 9 increased
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the EIH effectiveness induced by MCE. Inflammatory Large proportion of research has focused on the inflammation pathogenesis of intervertebral disc degeneration, which was a main contributor to LBP ( 50 ). The events initiating inflammatory
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criteria. Exclusion criteria: studies that report on patients who have additional concomitant conditions other than lateral recess stenosis, disc herniation, disc degeneration, spondylolisthesis, or scoliosis, studies that report on