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Elisa Pala Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Alberto Procura Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Antonio Berizzi Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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excellent mechanical resistance and still represent an option when approaching a pathologic or impending fracture of long bones ( 14 , 15 , 16 , 17 ). However, titanium nails show some limits, especially during the follow-up of patients. First, titanium

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Andrea Angelini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Nicolò Mosele Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Elisa Pagliarini Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy

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, 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ). Surgical treatment In GSD, surgery is mainly used to treat complications. The orthopedic surgeon is involved in case of pathological fracture, impending

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Morten Schultz Larsen Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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Hagen Schmal Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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comparison of different features eventually led to the definition provided by the ASBMR in 2010. 7 This is very helpful in cases of complete fracture, but impending fractures must also be diagnosed and treated before they become complete. Recognizing

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Julie J. Willeumier Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Yvette M. van der Linden Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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Michiel A.J. van de Sande Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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P.D. Sander Dijkstra Department of Orthopaedics, Leiden University Medical Centre, The Netherlands

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, pain is the most common symptom, followed by impending or actual pathological fractures in 10%-25% of patients. 5 Pathological fractures of the femur, 75% of which present in the proximal part, are roughly 3.5 times as common as fractures of the

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Catalin Cirstoiu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Cretu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Sergiu Iordache Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Mihnea Popa Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Serban Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Adrian Cursaru Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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treatment method ( Tables 1 and 2 ). Table 1 Surgical treatment of lower limb metastatic disease of the bone. Anatomical location Single metastasis (fractured or not) Multiple metastases Any type of metastasis Impending

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Nicolas Gallusser Department of Orthopaedics and Traumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

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Bardia Barimani Division of Orthopedic Surgery, McGill University, Montreal, Canada

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Frédéric Vauclair Department of Orthopaedics and Traumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

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nailing. Fracture characteristics and patterns in which IMN has been found to be superior are pathological and impending fractures, segmental lesions and fractures in osteopenic bone ( Table 1 ). 11 , 12 A simple middle third transverse fracture is

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Miklós Szendrői Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Imre Antal Department of Orthopaedics, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Attila Szendrői Department of Urology, Semmelweis University, H-1082 Budapest, Üllői 78/b, Hungary

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Áron Lazáry National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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Péter Pál Varga National Center for Spinal Disorders, H-1126 Budapest, Királyhágó u.1., Hungary

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and oncologists to establish the correct diagnosis and plan the most favourable treatment accordingly. Our own protocol is presented in Figure 1 . Fig. 1 Diagnostic algorithm at impending fracture (known primary tumour). In cases of an

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Logan Petit Department of Orthopedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA

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Theodore Zaki Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA

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Walter Hsiang Department of Orthopedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA

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Michael P. Leslie Department of Orthopedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA

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Daniel H. Wiznia Department of Orthopedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA

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impending crash by stretching out their leg in an attempt to right the motorcycle and catch themselves. The foot may impact first causing a hyperdorsiflexion, external rotation injury. Milder forms of these injuries can present as simple fracture

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Stijn E. W. Geraets Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

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P. Koen Bos Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

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Johan van der Stok Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands

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with impending or actual pathological fractures. 5 Those impending or actual pathological fractures regularly require surgical treatment in order to prevent or stabilize fractures. Surgical procedures used to stabilize impending or actual

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Feng Xie The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China

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Shuya Sheng Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, UK

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Jeya Palan Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, UK

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Hemant G Pandit Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, Leeds, UK

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( 14 ). From the 1970s to the 1980s, HRA, consisting of a metal femoral head with a polyethylene acetabulum, became popular. However, the early failure rate was very high due to various causes, including femoral neck fracture, femoral prosthesis

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