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Introduction Giant cell tumour (GCT) of bone is a relatively rare, locally aggressive benign neoplasm associated with a wide pathological spectrum, ranging from latent benign to highly recurrent and, occasionally, malignant metastatic
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Introduction Denosumab is a fully humanised monoclonal antibody of the RANK ligand (nuclear factor kappa B ligand) which inhibits the RANK–RANKL interaction. The mononuclear stromal cells of giant cell tumour of bone (GCTB) overexpress RANKL
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all foot tumours) 1 , 2 and lipomata arise onthe dorsum of the foot. 3 Villonodular synovitis (or tenosynovial giant cell tumours) are more frequent and deep-seated lesions and plantar fibromatosis or epidermal inclusion cysts and foreign
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the osteoid osteoma, the giant cell tumour, the aneurysmal bone cyst and the fibrous dysplasia. Ewing sarcoma, osteosarcoma and chondrosarcoma of the elbow are the most common malignant tumours, and occur more frequently in older patients with the
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the location of the anomaly within that bone. The site of the lesion is sometimes pathognomonic. Giant cell tumour (a usually benign but locally aggressive disease) classically crosses the physis into the epiphysis and extends through the subchondral
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with metaplastic cartilage and bone formation. (D–G) Definite treatment consisted of marginal resection via plantar and dorsal approaches with exposure of the metatarsals. Localised (nodular) tenosynovial giant cell tumour Localized
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.05.008 ) 10 Gaston CL Bhumbra R Watanuki M Abudu AT Carter SR Jeys LM Tillman RM & Grimer RJ . Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone? Journal of Bone and Joint Surgery
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extend to skeletal muscle. (I) (H&EX100) Well-formed bone trabeculae, osteoid and plump fibroblasts in collagenized stroma. Cystic areas are noted at the lower left. (J) (H&EX200) Areas of multinucleated osteoclast-like giant cells adjacent to osteoid. (K
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Introduction Tenosynovial giant-cell tumour (TGCT) has been previously known as a giant-cell tumour of the tendon sheath or pigmented villonodular synovitis (PVNS), and can also be called a xanthogranuloma, a benign synovioma, or a fibrous
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hypothesis of a lipid metabolic disorder associated with an anomaly of the local lipid metabolism is a possible aetiology. 13 , 14 Histology Tenosynovial giant-cell tumours can be divided into two categories, depending on their location (intra
