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similar eradication rates following periods of 6 weeks post-operative antibiotic therapy or less, compared to longer periods following DAIR (Debridement, Antibiotics and Implant Retention) and single-stage revision arthroplasty ( 26 , 27 , 28 ). The
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articulating The rate of eradication of infection The functional knee score: KSS, OKS, HSS The range of motion after the whole procedure Results Thirty-two original articles describing the management of periprosthetic joint
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when satisfactory infection control has been achieved: wound healing and normal erythrocyte sedimentation rate/C-reactive protein level measured at three consecutive follow-up visits indicate eradication of infection. 4 , 6 , 12 , 16 , 21 , 24
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side effects and potential drug–drug interactions ( 17 , 20 , 21 ). Scheper et al. (2021) in a systematic review and meta-analysis showed that the addition of rifampicin was associated with a 10% increase in the success rate of PJI eradication. In
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prostheses could partly explain these findings. Despite Jacquot 21 and Coste’s 27 studies, the literature reports a high rate of infection eradication, reaching more than 90% of cases. 9 , 27 , 29 , 32 , 44 , 45 Fig. 2 Radiographs (a and b
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and re-implantation of a new prosthesis. 35 Numerous studies have reported that two-stage revision with the use of antibiotic spacers can result in infection eradication rates at the level of 80–95%, and the use of articulating spacers improves
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adjunctive OsteoSet-T® with only local debridement and another included multiple biomaterials for antibiotic delivery used for treating osteomyelitis. All publications reported good rates of eradication, ranging from 80% to 100%, complete or almost
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hip, 6993 knee) performed in our unit showed that PJI MSSA rate was 0.75% prior to screening, which reduced to 0.25% with introduction of screening and implantation of this eradication strategy (p < 0.0001). The overall PJI rate fell from 1.92% to 1
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treatment suppresses but does not eradicate the infection with a higher re-infection rate. 37 The efficiency of antibiotic-loaded polymethylmethacrylate (PMMA) beads and other non-biological or bio-absorbable antibiotic carriers (e.g. calcium sulphate
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et al. reported that two-stage arthroplasty obtains satisfactory eradication rates in patients with SA ( 29 ). Anagnostakos et al. found that although the rate of infection eradication with two-stage arthroplasty was 87%, the mortality rate was as
