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Carlos A. Encinas-Ullán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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José M. Martínez-Diez Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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Introduction External fixators (EF) are essential tools in trauma emergencies. EF in the emergency department (ED) is used as a provisional method for stabilizing complex, open fractures, for treating fractures in the presence of burns

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Irina-Anca Eremia Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Mihnea Popa Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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Adela Iancu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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Silvia Nica Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania

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structure and function. Figure 3 The case of a 59-year-old male patient with an unremarkable medical history and no previous hospitalizations. The patient arrived at the emergency department with a sudden onset of pain and limited ability to

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Bogdan Serban Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Adrian Cursaru Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Cornelia Nitipir Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Cristina Orlov-Slavu Department of Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Elias University Emergency Hospital, Bucharest, Romania

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Catalin Cirstoiu Department of Orthopedics and Traumatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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appear to be no recurrence. Figure 1 A 77-year-old patient diagnosed approximately 2 years ago with liposarcoma is referred to our department with a rapidly increasing mass located at the root of the thigh (A). The MRI (coronal T1) revealed a tumor

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Theofilos Karachalios Orthopaedic Department, University General Hospital of Larissa, Biopolis, Mezourlo Region, Larissa, Hellenic Republic
School of Health Sciences, Faculty of Medicine, University of Thessaly, Biopolis, Mezourlo Region, Larissa, Hellenic Republic

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Katre Maasalu Clinic of Traumatology and Orthopedics, Tartu University Hospital, Tartu, Estonia
Department of Traumatology and Orthopedics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia

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Li Felländer-Tsai Division of Orthopaedics and Biotechnology, CLINTEC, Karolinska Institutet, Stockholm, Sweden
Trauma, Emergency Surgery and Orthopaedics, Reconstructive Orthopaedics, Karolinska University Hospital, Stockholm, Sweden

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World Health Organization (WHO) declared a global pandemic which dramatically changed the priorities and activities of public and health systems ( 2 ). For a considerable period of time, elective surgery was halted and only emergency procedures were

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Razvan Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Dragos Ene Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
Bucharest Emergency Clinical Hospital, Romania

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Adrian Cursaru Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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  • Infection in orthopaedic and trauma surgery remains a destructive complication with particularly challenging diagnosis and treatment due to bacterial antibiotic resistance and biofilm formation.

  • Along with surgical debridement and systemic antibiotics, an important type of adjuvant therapy is local antibiotic delivery, with the purpose of eliminating bacterial colonization and biofilm development.

  • Calcium sulphate, as a synthetic absorbable biomaterial used for local antibiotic delivery, has experienced an increasing popularity during the last decade, with multiple promoted advantages such as predictable antibiotic elution kinetics, complete and quick biodegradation, good biocompatibility, and limited associated complications.

  • A series of commercially available antibiotic-delivery systems based on calcium sulphate are under investigation and in clinical use, with different presentations, compositions, and application techniques.

  • The current article presents the main available calcium-sulphate-based products and the existing data about the clinical and preclinical research results, stemming from their implementation as local antibiotic carriers for surgical site and implant-associated infections treatment and prevention.

Cite this article: EFORT Open Rev 2021;6:297-304. DOI: 10.1302/2058-5241.6.200083

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Catalin Cirstoiu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Cretu Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Bogdan Serban Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Zsombor Panti Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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Mihai Nica Carol Davila University of Medicine and Pharmacy, Orthopedics and Traumatology Department, Bucharest, Romania
University Emergency Hospital Bucharest, Romania

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  • Modern surgical management of extremity bone sarcomas is governed by limb-sparing surgery combined with adjuvant and neoadjuvant chemotherapy.

  • All the resection and reconstruction techniques have to achieve oncologic excision margins, with survival rates and functional results superior to amputation.

  • The main reconstruction techniques of bone defects resulted after resection are: modular endoprosthetic reconstruction; bone graft reconstruction; bone transport; resection arthrodesis; and rotationplasty.

  • Oncologic resection and modular endoprosthetic reconstruction are the generally approved surgical options adopted for the majority of cases in major specialized bone sarcoma centres.

  • Good basic principles, efficient multidisciplinary approach and sustained research in the field can provide a better future for the challenge posed by extremity bone sarcoma treatment.

Cite this article: EFORT Open Rev 2019;4:174-182. DOI: 10.1302/2058-5241.4.180048

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Michael de Buys Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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Krisantha Moodley Emergency Department, ER Consulting, Johannesburg, South Africa

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Josip Nenad Cakic Department Orthopaedic Surgery, Life Fourways Hospital, Johannesburg, South Africa

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Jurek R T Pietrzak Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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  • Peri-prosthetic joint infections (PJIs) following total joint arthroplasty (TJA) are associated with higher treatment costs, longer hospital admissions and increased morbidity and mortality.

  • Colonization with Staphylococcus aureus is an independent and modifiable risk factor for PJIs and carriers of S. aureus are ten times more likely than non-carriers for post-operative infections.

  • Screening and targeted decolonization, vs universal decolonization without screening, remains a controversial topic.

  • We recommend a tailored approach, based on local epidemiological patterns, resource availability and logistical capacity.

  • Universal decolonization is associated with lower rates of SSI and may reduce treatment costs.

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Catalin Cirstoiu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Cretu Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Sergiu Iordache Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Mihnea Popa Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Bogdan Serban Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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Adrian Cursaru Orthopedics and Traumatology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania

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important to the pathologist in the final diagnosis ( 1 ). A separate category is patients who present in the emergency room with a pathological bone fracture. Most pathological bone fractures are secondary to metastatic disease, but benign bone lesions

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Michaël Moeri Division of Orthopaedic and Trauma Surgery, Geneva University Hospitals, Switzerland

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Dominique A. Rothenfluh Oxford University Hospitals NHS Foundation Trust, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, UK

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Christoph J. Laux Division of Orthopaedic and Trauma Surgery, Geneva University Hospitals, Switzerland

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Dennis E. Dominguez Division of Orthopaedic and Trauma Surgery, Geneva University Hospitals, Switzerland
Oxford University Hospitals NHS Foundation Trust, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, UK

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a stiff cervical collar (C-collar). For optimal patient management, protocols should predetermine all actions taken in the emergency department (ED). This will help to minimize the time of cervical restriction, without, however, jeopardizing

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John-Henry Rhind Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Eamon Ramhamadany Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Ruaraidh Collins Basingstoke and North Hampshire Hospital, Basingstoke, Hampshire, UK

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Siddharth Govilkar Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Debashis Dass Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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Stuart Hay Robert Jones Agnes Hunt Hospital, Oswestry, Shropshire, UK

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must be sought at this time. In England, 1.8 million fractures occur annually with a lifetime prevalence of nearly 40%, 36 whilst 4.6% of all emergency department (ED) attendances are represented by dislocations, joint injuries, fractures and

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