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E Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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Alberto D Delgado-Martínez Department of Orthopaedic Surgery, Hospital Universitario de Jaén, Jaén, Spain
Department of Surgery, University of Jaén, Jaén, Spain

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Javier De Andrés-Ares Department of Anesthetics, Pain Unit, La Paz University Hospital, Madrid, Spain

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Introduction The use of radiofrequency (RF, also known as rhizotomy or neurotomy) for managing chronic pain was first reported in 1931 when Kirschner described the management of trigeminal neuralgia by applying RF to the Gasserian ganglion ( 1

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Dieter Wirtz Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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Hendrik Kohlhof Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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orthopaedic procedures, older adult patients, especially with co-morbidities, need a more intensive level of care than younger patients during the pre- peri- and post-operative periods. 2 – 4 Pre-operative management In the pre-operative period the

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, La Paz University Hospital-IdiPaz, Madrid, Spain

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provision of the missing coagulation factor, haemorrhages can be controlled and conservative orthopaedic management can usually terminate the episode without any long-term complications. Should the haemorrhage persist or a re-bleed occur, intra

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Leonard Christianto Singjie Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

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Reynaldo Halomoan Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

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Ifran Saleh Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia

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Endrotomo Sumargono Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia

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Erica Kholinne Department of Orthopedic Surgery, St. Carolus Hospital, Jakarta, Indonesia
Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia

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thrombosis (DVT) and pulmonary embolism (PE) are the most common forms of VTE incidence, causing significant morbidity and mortality ( 1 ). VTE in major orthopedic surgery is caused by several prothrombotic mechanisms, such as vein injury, coagulation

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Stavros Tsotsolis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece
Trauma and Orthopaedics Department, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Eustathios Kenanidis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Vasileios F Pegios Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Michael Potoupnis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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Eleftherios Tsiridis Academic Orthopaedic Department, Aristotle University Medical School, General Hospital Papageorgiou, Ring Road Efkarpia, Thessaloniki, Greece
Centre of Orthopaedic and Regenerative Medicine (CORE), Center for Interdisciplinary Research and Innovation (CIRI)-Aristotle University of Thessaloniki (AUTH), Balkan Center, Buildings A & B, Thessaloniki, Greece

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in shortening clot lysis time ( 30 ). The role of thyroid insufficiency on coagulation factor synthesis and function is emphasized by the reversal of the acquired von Willebrand Syndrome (aVWS) seen after thyroid hormone replacement therapy ( 29

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Dimitrios A. Flevas First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis D. Megaloikonomos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Leonidas Dimopoulos First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Evanthia Mitsiokapa First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis Koulouvaris First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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management of venous thromboembolism. SIGN publication no. 122 . Edinburgh : SIGN ; 2010 . 17. Anderson FA Jr Spencer FA. Risk factors for venous thromboembolism . Circulation 2003 ; 107 ( suppl 1 ): I9 - I16 . 18

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Thomas Collins Trauma & Orthopaedics, Wythenshawe Hospital, Wythenshawe, UK

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Dinesh Alexander Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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Bilal Barkatali Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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coagulation cascade of collected blood. Ethylenediaminetetraacetic acid (EDTA) suppresses platelet degranulation and therefore is not recommended for PRP. Conversely, heparin can cause spontaneous aggregation of platelets in some individuals. Anticoagulant

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Shaho Hasan Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Peter van Schie Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, The Netherlands

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Bart L Kaptein Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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Jan W Schoones Walaeus Library, Leiden University Medical Centre, Leiden, The Netherlands

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Perla J Marang-van de Mheen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands
Department of Safety & Security Science, Delft University of Technology, Delft, The Netherlands

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Rob G H H Nelissen Department of Orthopaedics, Leiden University Medical Centre, Leiden, The Netherlands

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after total hip replacement: molecular pathology and clinical management . Inflammopharmacology 2013 21 389 – 396 . ( https://doi.org/10.1007/s10787-013-0192-6 ) 24 Aghayev E Teuscher R Neukamp M Lee EJ Melloh M Eggli S & Röder C

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Giorgio Perino Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany

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Ivan De Martino Division of Orthopaedics and Traumatology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

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Lingxin Zhang Department of Pathology and Laboratory Medicine, Sinai Health System, Toronto, Canada

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Zhidao Xia Centre for Nanohealth, Swansea University Medical School, Singleton Park, Swansea, UK

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Jiri Gallo Department of Orthopaedics, Faculty of Medicine and Dentistry, University Hospital, Palacky University Olomouc, Czech Republic

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Shonali Natu Department of Pathology, University Hospital of North Tees and Hartlepool NHS Foundation Trust, Stockton-on-Tees, UK

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David Langton Orthopaedic Department, Freeman Hospital, Newcastle upon Tyne, UK

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Monika Huber Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Wien, Austria

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Anastasia Rakow Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany

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Janosch Schoon Department of Orthopedics and Orthopedic Surgery, University Medicine Greifswald, Greifswald, Germany

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Enrique Gomez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Veit Krenn MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik-GmbH, Trier, Germany

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involved in the diagnosis and management of ALTR/ARMD and of clarification of the parameters used in the proposed semi-quantitative scoring systems for its classification has been recently emphasized. 37 The aims of this review article on the

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