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-negative Enterobacteriaceae (E. coli, Klebsiella, Enterobacter etc.) - Ciprofloxacin 750 mg, every 12 h p.o. Nonfermenteres (Pseudomonas aeruginosa, Acinetobacter spp.) 2–3 weeks: - Piperacillin/tazobactam or - Meropenem or - Ceftazidim + - Tobramycin or
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be challenging. 22 With reference to ODRI, bacteria resistant to the few antibiotics with proven anti-biofilm activity (Rifampicin-resistant staphylococci and ciprofloxacin-resistant Gram-negatives) are among the most difficult pathogens to treat
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susceptibility to antibiotics used for treatment of PJI remained largely unchanged, including rifampicin, daptomycin and vancomycin against gram-positive bacteria or ciprofloxacin, meropenem and ceftazidime against gram-negative bacteria. Table 2. Number of
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and ciprofloxacin . Antimicrob Agents Chemother 2003 ; 47 : 1251 – 1256 . 11. Gbejuade HO Lovering AM Webb JC . The role of microbial biofilms in prosthetic joint infections . Acta Orthop 2015 ; 86 : 147
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fenestrated and necrotic bone sequestra excised. Suction drain placed in remaining gutter. Dead space obliterated with free muscle transfer. IV ciprofloxacin given at time of surgery and then orally for 6 weeks post-operatively. If microbiology culture and