Ludwig Maximilian University Munich, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Zentrum München (MUM), Marchionostraße, Munich, Germany
Justus Maximilian University Wuerzburg, König-Ludwig-Haus, Brettreichstraße, Würzburg, Germany
Paracelsus Medizinische Privatuniversität, Strubergasse, Salzburg, Austria
Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany
Search for other papers by Markus Walther in
Google Scholar
PubMed
Ludwig Maximilian University Munich, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Zentrum München (MUM), Marchionostraße, Munich, Germany
Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany
Search for other papers by Oliver Gottschalk in
Google Scholar
PubMed
Martin-Luther-University Halle-Wittenberg, Universitätsklinikum Halle (Saale), DOUW - Abteilung für Unfall- und Wiederherstellungschirurgie, Ernst-Grube-Straße, Halle, Germany
BG-Klinikum Bergmannstrost Halle, Halle, Saale, Germany
Search for other papers by Matthias Aurich in
Google Scholar
PubMed
marrow stimulation (scientifically neutral term, includes protected trademarks like MFx®, Microfracture®, Nanofracture®, Microdrilling®) M-BMS Matrix-associated bone marrow stimulation (scientifically neutral term, includes protected trademarks
Search for other papers by Alfonso Vaquero-Picado in
Google Scholar
PubMed
Search for other papers by E. Carlos Rodríguez-Merchán in
Google Scholar
PubMed
Supplemental bone marrow stimulation These techniques are designed to recreate the environment of an ACL reconstruction to enhance healing of isolated meniscal tears. While in ACL reconstruction drilling tunnels releases growth factors, blood and platelets
Search for other papers by Enrique Gómez-Barrena in
Google Scholar
PubMed
Search for other papers by Norma G. Padilla-Eguiluz in
Google Scholar
PubMed
Search for other papers by Philippe Rosset in
Google Scholar
PubMed
cells to stimulate osteogenesis . Clin Orthop Relat Res 1998 ; 355 : S257 – S266 . 40. Connolly JF . Injectable bone marrow preparations to stimulate osteogenic repair . Clin Orthop Relat Res 1995 ; 313 : 8 – 18 . 41
Search for other papers by Simon Donell in
Google Scholar
PubMed
joint loading. Abnormal loading leads to microfractures within the osteochondral junction and within the subchondral bone. The advent of MRI scanning has shown bone marrow lesions within the subchondral bone, associated with degenerative changes in the
Search for other papers by Maurilio Marcacci in
Google Scholar
PubMed
Search for other papers by Luca Andriolo in
Google Scholar
PubMed
Search for other papers by Elizaveta Kon in
Google Scholar
PubMed
Search for other papers by Nogah Shabshin in
Google Scholar
PubMed
Search for other papers by Giuseppe Filardo in
Google Scholar
PubMed
Introduction Bone marrow lesions (BMLs) around the knee are a common MRI finding. BML is defined as an alteration of the signal intensity of the bone marrow, with high signal on fluid-sensitive sequences (T2/proton density with fat suppression
IRCCS Galeazzi Orthopedic Institute, Milan, Italy
Search for other papers by Luca Pierannunzii in
Google Scholar
PubMed
IRCCS Galeazzi Orthopedic Institute, Milan, Italy
Search for other papers by Luigi Zagra in
Google Scholar
PubMed
devascularised with surgical exposure, whichever approach is chosen. The latter is biologically richer in cells and growth factors, since the pelvis is mostly made up of cancellous bone with bone marrow content and blood vessels and the exposure rarely affects
Search for other papers by Paul L Rodham in
Google Scholar
PubMed
Search for other papers by Vasileios P Giannoudis in
Google Scholar
PubMed
Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland
Search for other papers by Nikolaos K Kanakaris in
Google Scholar
PubMed
Search for other papers by Peter V Giannoudis in
Google Scholar
PubMed
site morbidity to the patient ( 17 ). Augmentation of osteogenesis and osteoinduction can be provided through the use of bone marrow aspirate concentrates (BMACs); however, this provides no augmentation of osteoconduction and concerns have been raised
Search for other papers by Daniel Petek in
Google Scholar
PubMed
Search for other papers by Didier Hannouche in
Google Scholar
PubMed
Search for other papers by Domizio Suva in
Google Scholar
PubMed
cortisone and alcohol have a profound effect on bone marrow differentiation and blood supply. However, these studies do not explain why the vast majority of patients who abuse alcohol never develop the disease. There is a hypothesis of a genetic
Search for other papers by Elena Gálvez-Sirvent in
Google Scholar
PubMed
Search for other papers by Aitor Ibarzábal-Gil in
Google Scholar
PubMed
Search for other papers by E. Carlos Rodríguez-Merchán in
Google Scholar
PubMed
at the fracture site can stimulate bone healing. 2 Nail dynamization can be accomplished by removing all locking screws on one side of the nail. The disadvantage of this is that instability then occurs, especially for rotation. A more stable
Search for other papers by Sakae Tanaka in
Google Scholar
PubMed
mediated by teriparatide-induced RANKL expression in osteoblasts and/or bone marrow stromal cells, which leads to increased osteoclastogenesis. The anabolic effect of teriparatide is at least partially mediated by the direct effect of teriparatide on
