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  • autologous protein solution x
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Hamid Rahmatullah Bin Abd Razak Department of Bioengineering, Imperial College London, London, UK
Sengkang General Hospital, Singapore
Joint first authors

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Daniel Chew Faculty of Medicine, Imperial College London, London, UK
Joint first authors

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Zepur Kazezian Department of Bioengineering, Imperial College London, London, UK

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Anthony M.J. Bull Department of Bioengineering, Imperial College London, London, UK

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), such as autologous protein solution (APS) and autologous conditioned serum (ACS), have been fabricated as emerging therapies for knee OA. 10 In a systematic review by Ajrawat et al, it was concluded that AILBPs are a safe and tolerable injection

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.6.200040
Volume/Issue:
Volume 6: Issue 9
Open access
Enrique Gómez-Barrena Department of Orthopaedic Surgery and Traumatology, Hospital La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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Christian Ehrnthaller Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Germany

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biological therapies under development, cells are the most promising actor to be incorporated. Whether autologous aspirated, concentrated, or expanded, further research on cell therapy will provide refined solutions of sufficient potency to predict and obtain

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-24-0032
Volume/Issue:
Volume 9: Issue 5
Open access
Giorgio Maria Calori ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Emilio Mazza ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Alessandra Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Simone Mazzola ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Massimiliano Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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on their leisure activities and work status. There is consequently great interest in trying to preserve the FH whenever possible. Recently, surgeons have considered combining CD with autologous bone-marrow cells, demineralised bone matrix, 16

Article Type:
Research Article
Category:
Hip
DOI:
https://doi.org/10.1302/2058-5241.2.150006
Volume/Issue:
Volume 2: Issue 2
Open access
Paul L Rodham Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Vasileios P Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Nikolaos K Kanakaris Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland
Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland

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Peter V Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Blokhuis TJ Patka P Bakker FC & Haarman HJTM . Healing of segmental bone defects with granular porous hydroxyapatite augmented with recombinant human osteogenic protein-I or autologous bone marrow . Journal of Orthopaedic Research 2003 21 521

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-23-0047
Volume/Issue:
Volume 8: Issue 5
Open access
Sebastian Kopf Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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Manuel-Paul Sava Orthopedics and Traumatology 2nd Department, Colentina Clinical Hospital, Bucharest, Romania

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Christian Stärke Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Germany

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Roland Becker Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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femoral condyle. Note . ACT, autologous chondrocyte transplantation; OCT, osteochondral transplantation. Histologically, one of the main components of both cartilage and menisci is collagen: menisci contain mainly type I and articular cartilage

Article Type:
Review Article
Category:
Knee
DOI:
https://doi.org/10.1302/2058-5241.5.200016
Volume/Issue:
Volume 5: Issue 10
Open access
Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Sven Geissler Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Tazio Maleitzke Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Carsten Perka Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Georg N Duda Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Alexander Hildebrandt Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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-biased reporting, such as those offered by companies like Analgesics Solutions ( https://www.wcgclinical.com/analgesic-solutions/ ), might also be an appropriate approach to mitigate placebo effects. Detailed knowledge about the pathophysiology of the disease

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-24-0084
Volume/Issue:
Volume 9: Issue 9
Open access
Elena Gálvez-Sirvent Department of Orthopaedic Surgery, ‘Infanta Elena’ University Hospital, Valdemoro, Madrid, Spain

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Aitor Ibarzábal-Gil Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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reaming at the nonunion site. In addition, an extra contribution from autologous iliac crest bone graft (AICBG) and a graft from the osteotomized fibula had been added to the atrophic nonunions. Bone healing had been achieved in 100% of patients in an

Article Type:
Review Article
Category:
Trauma
DOI:
https://doi.org/10.1302/2058-5241.5.190077
Volume/Issue:
Volume 5: Issue 11
Open access
Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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autologous blood derivate characterized by a higher platelet concentration than peripheral blood ( Fig. 2 ). The rationale behind the employment of platelets relies on the ability of the latter to release biologically active proteins that are able to promote

Article Type:
Review Article
Category:
Knee
DOI:
https://doi.org/10.1302/2058-5241.6.210026
Volume/Issue:
Volume 6: Issue 6
Open access
Joseph J Ruzbarsky Steadman Philippon Research Institute, Vail, Colorado, USA
Steadman Clinic and United States Coalition for the Prevention of Illness and Injury in Sport, Vail, Colorado, USA

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Rui W Soares Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, USA

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Spencer M Comfort Steadman Philippon Research Institute, Vail, Colorado, USA

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Justin W Arner Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Marc J Philippon Steadman Philippon Research Institute, Vail, Colorado, USA
Steadman Clinic and United States Coalition for the Prevention of Illness and Injury in Sport, Vail, Colorado, USA

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platelets within autologous plasma ( 19 ). Platelets themselves contain alpha and dense granules with the former secreting various growth factors, chemokines, cytokines, and proteins like insulin growth factor 1 ( 28 ). PRP can further be prepared as a

Article Type:
Review Article
Category:
Hip
DOI:
https://doi.org/10.1530/EOR-21-0068
Volume/Issue:
Volume 8: Issue 11
Open access
Maria-Pau Ginebra Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Montserrat Espanol Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Yassine Maazouz Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain
Mimetis Biomaterials, Spain

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Victor Bergez Mimetis Biomaterials, Spain

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David Pastorino Mimetis Biomaterials, Spain

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. They not only produce the organic molecules, i.e. collagen type I, glycosaminoglycans, transforming growth factors or bone morphogenetic proteins (BMPs), but also control the mineralization of collagen. After fulfilling their secretory activity

Article Type:
Research Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.3.170056
Volume/Issue:
Volume 3: Issue 5
Open access