Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
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can downregulate NGF expression, thus alleviating pain, improving limb function and relieving OA symptoms. The efficacy and safety of anti-NGF monoclonal antibodies vs placebo in the treatment of OA have been reported in systematic reviews, and the
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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IRCCS Humanitas Research Hospital, Milan, Italy
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First Moscow State Medical University – Sechenov University, Moscow, Russia
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IRCCS Humanitas Research Hospital, Milan, Italy
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): its use as an intra-articular injectable was found to be safe in humans and effective in reducing cartilage degeneration and synovial inflammation in animal models. 67 Moreover, monoclonal antibodies directed against nerve growth factor (NGF