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Andreas F. Mavrogenis Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis D. Megaloikonomos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Vasileios G. Igoumenou Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Georgios N. Panagopoulos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Efthymia Giannitsioti Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Antonios Papadopoulos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Panayiotis J. Papagelopoulos Attikon General University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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also elevated in most cases. 55 Nevertheless, these markers are also non-specific, since they are unable to distinguish between a pyogenic, granulomatous or other inflammatory process. Obviously, patients with acute disease may demonstrate a

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Alexios D. Iliadis Centre for Orthopaedics, The Royal London and Barts and The London Children’s Hospitals, Barts Health NHS Trust, London, UK

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Manoj Ramachandran Centre for Orthopaedics, The Royal London and Barts and The London Children’s Hospitals, Barts Health NHS Trust, London, UK

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. Osteomyelitis is the inflammation of bone caused by pyogenic organisms. Various descriptive classification systems have been developed. A description in terms of timing between onset and diagnosis distinguishes between acute (< 2 weeks), subacute (< 3 months

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Michalis Panteli Academic Department of Trauma & Orthopaedics, Leeds General Infirmary; School of Medicine, University of Leeds, UK

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Peter V. Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary; School of Medicine, University of Leeds, UK

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one is the most appropriate to use. In general terms, osteomyelitis is characterised as acute or chronic, based on its histopathological findings, rather than the duration of the infection. 9 Acute osteomyelitis typically presents two weeks after

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Tamer El-Sobky Division of Paediatric Orthopaedics, Department of Orthopaedic Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Shady Mahmoud Division of Paediatric Orthopaedics, Department of Orthopaedic Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Septic arthritis and acute haematogenous osteomyelitis are frequently encountered among otherwise healthy children and adolescents. Misdiagnosis may increase the likelihood of bone and joint complications. The slightest delay in appropriate

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Ricardo Sousa Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal
Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal

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André Carvalho Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Ana Cláudia Santos Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Miguel Araújo Abreu Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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M Kakalou E Fanourgiakis P Skoutelis A . Pyogenic vertebral osteomyelitis: a systematic review of clinical characteristics . Semin Arthritis Rheum 2009 ; 39 : 10 – 17 . 48. Marschall J Bhavan KP

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Dimitrios A. Flevas First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Sophia Syngouna Department of Upper Extremity Surgery and Microsurgery, KAT Hospital, Athens, Greece

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Emmanouel Fandridis Department of Upper Extremity Surgery and Microsurgery, KAT Hospital, Athens, Greece

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Sotirios Tsiodras Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Andreas F. Mavrogenis First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

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Coccidiomycosis can cause tenosynovitis in adults and osteomyelitis of the bones of the hand in children. 113 Aspergillus has been reported as an opportunistic pathogen in immunocompromised children with acute leukaemia and it is common in patients with

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Congcong He Department of Psychology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yong Zhao Department of Orthopedics, Shanghai Fengxian District Central Hospital, Shanghai, China

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Guangyong Yang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hainan Hong Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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great damage to joints, erode joint cartilage, increase the fragility of soft tissues and ligaments around the joints, and deteriorate soft tissue conditions ( 6 ). Acute SA is defined by those patients that present with altered clinical (fever

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Tristan Ferry Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
Université Claude Bernard Lyon 1, Villeurbanne, France
Centre de Références des IOA Complexes de Lyon, CRIOAc Lyon, Lyon, France
StaPath team, Centre International de Recherche en Infectiologie, CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France
Education and Clinical Officer of the ESCMID Study Group for Non-traditional Antibacterial Therapy (ESGNTA)

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Jolien Onsea Department of Trauma Surgery, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium

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Tiphaine Roussel-Gaillard Institut des Agents Infectieux, Centre de Biologie et de Pathologie du Nord, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

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Cécile Batailler Service de Chirurgie Orthopédique et de Médecine du Sport, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

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Thomas Fintan Moriarty AO Research Institute Davos, Clavadelerstrasse 8, Davos Platz, Switzerland

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Willem-Jan Metsemakers Department of Trauma Surgery, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium

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, in Poland, large case series from the 1980s reported a 90% success rate in patients with ‘pyogenic arthritis and myositis’, ‘osteomyelitis of long bones’ and ‘osteitis of long bones after fracture’ ( 35 , 36 ). Application protocols included topical

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