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Low-dose dexamethasone during arthroplasty

What do we know about the risks?

Jessica T. Wegener Department of Anesthesiology, Academic Medical Center (AMC), University of Amsterdam, The Netherlands

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Tim Kraal Department of Orthopedic Surgery, Academic Medical Center and the Orthopedic Research Center Amsterdam, The Netherlands

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Markus F. Stevens Department of Anesthesiology, Academic Medical Center (AMC), University of Amsterdam, The Netherlands

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Markus W. Hollmann Department of Anesthesiology, Academic Medical Center (AMC), University of Amsterdam, The Netherlands

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Gino M.M.J. Kerkhoffs Department of Orthopedic Surgery, Academic Medical Center and the Orthopedic Research Center Amsterdam, The Netherlands

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Daniël Haverkamp Department of Orthopedic Surgery, Slotervaart Ziekenhuis, Amsterdam, The Netherlands

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-operative strategies in preventing surgical site infections (SSI) after arthroplasty have been taken. Currently, conflicting views among orthopaedic surgeons and anaesthesiologists raise doubts on the use of dexamethasone during joint arthroplasty surgery. For

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Duy Nguyen Anh Tran The International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam

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Bao Tu Thai Nguyen The International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam

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Tan Thanh Nguyen Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam

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Yu-Pin Chen Department of Orthopedics, Taipei Municipal Wan-Fang Hospital, Taipei, Taiwan
Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Yi-Jie Kuo Department of Orthopedics, Taipei Municipal Wan-Fang Hospital, Taipei, Taiwan
Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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impact on mental health ( 4 , 5 , 6 , 7 , 8 ). Smoking is associated with impaired wound healing and increased susceptibility to surgical site infections (SSIs) ( 9 , 10 , 11 ). SSIs, occurring in 1–20% of patients after ankle and calcaneal

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Hua Luo Department of Orthopaedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yongwei Su The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, China

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Feng Xue Department of Orthopaedics, Fengxian District Central Hospital, Shanghai, People’s Republic of China

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Zhenghua Hong Department of Orthopaedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Introduction Surgery site infections (SSIs) is one of the common complications affecting surgical management and patient recovery. Related studies report that the incidence of SSIs is 1–14% ( 1 , 2 , 3 , 4 , 5 ). The incidence of SSIs is

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Chengxin Xie Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Liwei Zhang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Dehua Zhang Department of Emergency, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Lingjian Tao Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yong Zhao Department of Orthopedics, Shanghai Fengxian District Central Hospital, Shanghai 201400, China.

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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survival and efficacy of the knee replacement prosthesis, including poor alignment of the lower extremities, infection, aseptic loosening of the prosthesis, and anterior knee pain ( 1 ). Among these, surgical site infection (SSI) is the most common, with

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Michael de Buys Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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Krisantha Moodley Emergency Department, ER Consulting, Johannesburg, South Africa

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Josip Nenad Cakic Department Orthopaedic Surgery, Life Fourways Hospital, Johannesburg, South Africa

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Jurek R T Pietrzak Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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an ageing population, so too does the incidence of complications. Definitions Surgical site infections (SSIs) are defined as infections occurring within 90 days of surgery involving the skin or subcutaneous tissue, in the region of the body

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Philip F. Dobson Trauma and Orthopaedic Surgery, Royal Victoria Infirmary, Newcastle, UK

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Michael R. Reed Trauma and Orthopaedic Surgery, Royal Victoria Infirmary, Newcastle, UK

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further reduced infection. Despite the ongoing evolution and refinement of surgical practice, surgical site infection (SSI) remains a risk for every patient, including those undergoing primary total hip and knee arthroplasty procedures, and is associated

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Xinhuan Lei Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Jie Xiang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hailan Yang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hongya Bao Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Zhong Zhu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Introduction Surgical site infection (SSI) is a rare and serious complication of total knee arthroplasty (TKA) that can cause a poor prognosis, reduce these patients’ quality of life, and significantly increase the financial burden. Therefore

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Christof Berberich Department of Medical Training and Education, Heraeus Medical GmbH, Wehrheim, Germany

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Pablo Sanz-Ruiz Department of Traumatology and Orthopaedic Surgery, General University Hospital Gregorio Marañón, Madrid, Spain

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joint replacement procedures. 1 – 3 The choice of antibiotics used for prophylaxis requires an understanding of the common micro-organisms that cause surgical site infections (SSI) in orthopaedic procedures. Numerous studies have shown that gram

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Niels Hendrik Bech Slotervaart Center of Research and Education, The Netherlands

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Daniel Haverkamp Slotervaart Center of Research and Education, The Netherlands

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different type of impingement, a different search strategy was conducted. For the low anterior inferior iliac spine (AIIS) impingement, the following search terms were used: ((femoracetabular impingement OR impingement OR avulsion) and (subspine OR ssi OR

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hui Yu Department of Hematology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China
Department of Hematology, Enze Hospital, Taizhou Enze Medical Center (Group), Taizhou, Zhejiang, China

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Zhangfu Wang Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Wenjun Pan Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Lin Chen Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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contamination incision; and if the articles had missing data. Outcomes The primary outcome was the incidence of surgical site infection (SSI). Secondary outcomes included satisfaction and the incidence of other wound complications. Search strategy

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