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enhance bone repair due to osteoprogenitor cells. Mesenchymal stem cell (MSC) transplantation based on CD surgery can provide seed cells to promote repair and restoration of the FH, accelerate reconstruction and produce creeping substitution of new bone
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Introduction Mesenchymal stromal cells (MSCs) are easily accessed self-renewing cells with proliferation potential, multilineage differentiation potency, and immunoregulatory functions ( 1 ). Various cell sources can be used to isolate MSCs
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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First Moscow State Medical University – Sechenov University, Moscow, Russia
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IRCCS Humanitas Research Hospital, Milan, Italy
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products we include corticosteroids (CS), hyaluronic acid (HA), polynucleotides, oxygen-ozone therapy, platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs). CS and HA are ranked first as the most frequently injected substances and their use is
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
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Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan
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Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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, hyaluronic acids, platelet-rich plasma (PRP), platelet rich in growth factor (PRGF), botulinum toxin A, O 2 –O 3 , dextrose, and mesenchymal stem cell (MSC). Regarding exercise, most studies included resistance training programs to strengthen the quadriceps
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non-union treatment. Bone autograft is the safest and most effective grafting procedure, since it contains the patient’s mesenchymal stromal cells (MSCs) to enhance osteogenesis and growth factors to enhance osteo-induction, 16 while providing a
IRCCS Galeazzi Orthopedic Institute, Milan, Italy
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IRCCS Galeazzi Orthopedic Institute, Milan, Italy
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is the passive ability of a scaffold to be progressively substituted by viable bone; osteoinductivity is the capacity to stimulate the osteoblastic differentiation of local adult stem cells (i.e. mesenchymal stem cells, MSCs) through specific growth
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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numerous experimental and clinical studies, the broad application of stromal cell therapeutics is not yet emerging ( 45 ). To ensure comparability between cell experiments, the term MSC should only be used for cells that fulfil at least the minimal
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). Further, in vitro studies also suggested selective cytotoxicity of indirect CPP treatment in OS cells over mesenchymal stromal cells (MSCs) ( 79 ) and other less malignant cells ( 70 ). As mentioned earlier, it is assumed that the selectivity of CPP on
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( 12 ) and also a decrease in proliferation and differentiation of mesenchymal stem cells (MSCs) ( 13 ), which may suggest a systemic mesenchymal and osteogenic cell pool defect in patients sustaining this type of lesion. Those are the non-unions that
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osteoblasts, osteoclasts and bone marrow mesenchymal stem cells (MSCs). Rather than mature osteoblasts lining the resorption pits in damaged subchondral bone, the osteoblasts come from bone marrow-derived MSCs migrating and transforming into osteoblasts. 18