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Hua Luo Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chaojun Shen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Tongyou Qu Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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Lin Chen Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yue Sun Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang China

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is the main form of adverse reactions, such as brain toxicity. Drug-induced seizures often begin as isolated acute seizures but may potentially progress to persistent seizures. Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine

Article Type:
Review Article
Category:
Spine
DOI:
https://doi.org/10.1530/EOR-23-0016
Volume/Issue:
Volume 8: Issue 6
Open access
Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xuelei Zhang Department of Ultrasound, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Chengxin Xie Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Department of Endocrinology, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Luxia Wu Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Guoping Cai Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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spaces. Therefore, spinal surgeries cause a lot of bleeding and it is critical to address this intra- and post-operative bleeding. Tranexamic acid (TXA) is a synthetic lysine derivative that competitively inhibits plasminogen adsorption on fibrin and

Article Type:
Systematic Review
Category:
Spine
DOI:
https://doi.org/10.1530/EOR-23-0199
Volume/Issue:
Volume 9: Issue 8
Open access
Hua Luo Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Xueli Yan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Yu Ren Department of Pharmacy, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Han Zhang Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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Wenjun Pan Department of Orthopedic, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China

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autologous blood transfusion devices, as well as surgical modifications to reduce soft tissue damage. Tranexamic acid (TXA), as a synthetic antifibrinolytic drug, has been shown to significantly reduce bleeding during surgery in many surgical procedures. Its

Article Type:
Systematic Review
Category:
Spine
DOI:
https://doi.org/10.1530/EOR-23-0168
Volume/Issue:
Volume 8: Issue 12
Open access
Xiangji Dang Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, P.R. China
Department of Pharmaceutical, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Mei Liu The First Clinical Medical School, Gansu University of Chinese Medicine, Gansu, P.R. China

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Qiang Yang Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Jin Jiang Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Yan Liu Gansu High Throughput Screening and Creation Center for Health Products, School of Pharmacy, Lanzhou University, Lanzhou, P.R. China

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Hui Sun Cuiying Biomedical Research Center, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China

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Jinhui Tian Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, P.R. China

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preexisting thromboembolic risk profile. It is imperative to delve into these determinants comprehensively, exploring their individual and collective impact on patients undergoing TJA. Tranexamic acid (TXA), a potent antifibrinolytic agent, has become

Article Type:
Systematic Review
Category:
General Orthopaedics
DOI:
https://doi.org/10.1530/EOR-23-0140
Volume/Issue:
Volume 9: Issue 6
Open access
Dieter Wirtz Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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Hendrik Kohlhof Department of Orthopaedic Surgery and Traumatology, University Hospital of Bonn, Germany

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, the blood loss is reduced by approximately 20–25%, but improved wound healing has also been reported. 6 – 7 As a lysine analogue, tranexamic acid suppresses fibrinolytic activity by competitively inhibiting the binding of plasminogen and plasmin

Article Type:
Review Article
Category:
General Orthopaedics
DOI:
https://doi.org/10.1302/2058-5241.4.180087
Volume/Issue:
Volume 4: Issue 6
Open access
Marcel Niemann Charité – Universitätsmedizin Berlin, Center for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Ellen Otto Charité – Universitätsmedizin Berlin, Center for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Christian Eder Charité – Universitätsmedizin Berlin, Center for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Yasmin Youssef Department of Orthopaedics, Trauma Surgery and Plastic Surgery, University Hospital Leipzig, Leipzig, Germany

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Lutz Kaufner Charité – Universitätsmedizin Berlin, Department of Anesthesiology and Intensive Care Medicine, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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Sven Märdian Charité – Universitätsmedizin Berlin, Center for Musculoskeletal Surgery, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

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-induced coagulopathy is one of the leading causes of mortality among these patients ( 2 ), management beyond surgical measures gained further importance ( 3 ). Besides the early application of tranexamic acid (TXA) for trauma-induced bleeding patients, physicians

Article Type:
Review Article
Category:
Trauma
DOI:
https://doi.org/10.1530/EOR-22-0054
Volume/Issue:
Volume 7: Issue 10
Open access
Luigi Zagra Hip Department, IRCCS Istituto Ortopedico Galeazzi, Milan Italy

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is not justified nowadays. The use of tranexamic acid has been very effective in minimising the need for blood transfusions following THA. 21 , 22 Its increasing use has almost eliminated the need for other blood conservation strategies such as

Article Type:
Research Article
Category:
Hip
DOI:
https://doi.org/10.1302/2058-5241.2.170008
Volume/Issue:
Volume 2: Issue 5
Open access
Stefan Lazic South West London Elective Orthopaedic Centre, UK

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Oliver Boughton MSK Lab, Imperial College London, UK

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Catherine F. Kellett South West London Elective Orthopaedic Centre, UK

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Deiary F. Kader South West London Elective Orthopaedic Centre, UK

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Loïc Villet Centre de l’arthrose – Clinique du sport, Mérignac, France

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Charles Rivière South West London Elective Orthopaedic Centre, UK
MSK Lab, Imperial College London, UK

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Intra-operatively, tranexamic acid has proven to be effective and safe for haemostasis in TJA and is now considered as a game-changer for blood loss management. 53 The effects of tourniquet use are unclear at present, with earlier systematic reviews

Article Type:
Review Article
Category:
Hip
DOI:
https://doi.org/10.1302/2058-5241.3.170031
Volume/Issue:
Volume 3: Issue 4
Open access
Felix Christoph Finger BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Steffen Schröter Diakonie Klinikum Jung-Stilling GmbH, Department of Trauma and Reconstructive Surgery, Siegen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany

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Christoph Ihle BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Moritz Herbst BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Tina Histing BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Marc-Daniel Ahrend BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany
AO Research Institute Davos, Davos, Switzerland

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growing evidence for the use of tranexamic acid (TXA) for osteotomies. A systematic review by Bierke et al. confirmed a lower hemoglobin decrease, less total blood loss and lower drainage volume when using TXA during osteotomies at knee level, compared

Article Type:
Review Article
Category:
Knee
DOI:
https://doi.org/10.1530/EOR-23-0153
Volume/Issue:
Volume 9: Issue 7
Open access
Pietro Feltri Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland

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Camilla Mondini Trissino da Lodi Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland

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Alberto Grassi II Clinica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Stefano Zaffagnini II Clinica, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Christian Candrian Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland
Facoltà di Scienze Biomediche, Università della Svizzera Italiana, Lugano, Switzerland

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Giuseppe Filardo Orthopaedics and Traumatology Clinic, EOC, Lugano, Switzerland
Applied and Translational Research Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Facoltà di Scienze Biomediche, Università della Svizzera Italiana, Lugano, Switzerland

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their clinical consequences, identifying patients at more risk, and evaluating all the available strategies for reducing bleeding, such as tranexamic acid, which is safely and successfully used for knee surgery. 44 - 46 The meta-analysis supported the

Article Type:
Review Article
Category:
Knee
DOI:
https://doi.org/10.1302/2058-5241.6.210047
Volume/Issue:
Volume 6: Issue 11
Open access