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Pengqiang Lou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Guangzhi Zhou Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Bo Wei Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Xiaolei Deng Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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Decai Hou Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China

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  • This review summarizes the sclerotic zone's pathophysiology, characterization, formation process, and impact on femoral head necrosis.

  • The sclerotic zone is a reaction interface formed during the repair of femoral head necrosis.

  • Compared with normal bone tissue, the mechanical properties of the sclerotic zone are significantly enhanced.

  • Many factors influence the formation of the sclerotic zone, including mechanics, bone metabolism, angiogenesis, and other biological processes.

  • The sclerotic zone plays an essential role in preventing the collapse of the femoral head and can predict the risk of the collapse of the femoral head.

  • Regulating the formation of the sclerotic zone of the femoral head has become a direction worthy of study in treating femoral head necrosis.

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Patrick Goetti Department of Orthopaedics and Traumatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

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Patrick J. Denard Department of Orthopaedic & Rehabilitation, Oregon Health & Science University, Portland, Oregon, USA

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Philippe Collin Centre Hospitalier Privé Saint-Grégoire (Vivalto Santé), Saint- Grégoire, France

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Mohamed Ibrahim Department of Orthopaedics and Trauma Surgery, Faculty of Medicine, Fayoum University, Fayoum, Egypt

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Pierre Hoffmeyer Hirslanden Clinique des Grangettes, Geneva, Switzerland

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Alexandre Lädermann Division of Orthopaedics and Trauma Surgery, La Tour Hospital, Meyrin, Switzerland
Faculty of Medicine, University of Geneva, Geneva, Switzerland
Division of Orthopaedics and Trauma Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland

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  • The stability of the glenohumeral joint depends on soft tissue stabilizers, bone morphology and dynamic stabilizers such as the rotator cuff and long head of the biceps tendon. Shoulder stabilization techniques include anatomic procedures such as repair of the labrum or restoration of bone loss, but also non-anatomic options such as remplissage or tendon transfers.

  • Rotator cuff repair should restore the cuff anatomy, reattach the rotator cable and respect the coracoacromial arch whenever possible. Tendon transfer, superior capsular reconstruction or balloon implantation have been proposed for irreparable lesions.

  • Shoulder rehabilitation should focus on restoring balanced glenohumeral and scapular force couples in order to avoid an upward migration of the humeral head and secondary cuff impingement. The primary goal of cuff repair is to be as anatomic as possible and to create a biomechanically favourable environment for tendon healing.

Cite this article: EFORT Open Rev 2020;5:508-518. DOI: 10.1302/2058-5241.5.200006

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Lars Henrik Frich Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Denmark

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Morten Schultz Larsen Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Denmark

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and classification Authors have attempted to classify glenoid fractures for both prognostic and treatment purposes. 20 It has, however, been claimed that the existing classification systems are purely descriptive with no therapeutic implications

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Sebastian Siebenlist Department of Orthopaedic Sports Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany

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Arne Buchholz Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany

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Karl F. Braun Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany

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. 64. Pipicelli JG Chinchalkar SJ Grewal R King GJ . Therapeutic implications of the radiographic ‘drop sign’ following elbow dislocation . J Hand Ther 2012 ; 25 : 346 – 353 . 65. Hume MC

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Ignacio Sanpera Hospital Universitary Son Espases, Palma de Mallorca, Illes BalearsSpain

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Sandra Villafranca-Solano Hospital Universitary Son Espases, Palma de Mallorca, Illes BalearsSpain

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Carmen Muñoz-Lopez Hospital Universitary Son Espases, Palma de Mallorca, Illes BalearsSpain

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Julia Sanpera-Iglesias Evelina Children’s Hospital, London, UK

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with pes cavovarus, as is commonly done, because the diagnostic and therapeutic implications are completely different. Pes cavovarus denotes the presence of a three-dimensional deformity of the foot, but it is a descriptive feature not a diagnosis

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Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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B Chisari E et al. The role of Wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine . BioMed Res Int 2018 ; 2018 : 7402947 . 26. Filardo G Kon

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Xiaofeng Deng Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Haoran Xu Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xiaoxia Hao Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Jiawei Liu Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Xingru Shang Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Tao Xu Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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7. Coryell PR Diekman BO Loeser RF . Mechanisms and therapeutic implications of cellular senescence in osteoarthritis . Nature Reviews. Rheumatology 2021 17 47 – 57 . ( https://doi.org/10.1038/s41584-020-00533-7 ) 33208917 8. van den Bosch

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Geert Meermans Bravis Hospital, Roosendaal, The Netherlands

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George Grammatopoulos The Ottawa Hospital, Ottawa, Ontario, Canada

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Moritz Innmann Heidelberg University Hospital, Heidelberg, Germany

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David Beverland Belfast Health and Social Care Trust, Belfast, UK

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MM Weishorn J Beaule PE Grammatopoulos G Merle C . Pathologic spinopelvic balance in patients with hip osteoarthritis: preoperative screening and therapeutic implications . Der Orthopade 2020 49 860 – 869 . ( https://doi.org/10.1007/s00132

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Olga Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece
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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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Ioannis Zafeiris First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Dimitra Melissaridou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
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of 46 cases . Cancer 1999 ; 85 : 1044 – 1054 . 11. Nouri H Ben Maitigue M Abid L et al. Surface osteosarcoma: clinical features and therapeutic implications . J Bone Oncol 2015 ; 4 : 115 – 123 . 12. Gholamrezanezhad

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Nick Evans University Hospital of Wales, Cardiff, UK

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Michael McCarthy University Hospital of Wales, Cardiff, UK

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classification that specifically considers the parameters that affect spino-pelvic sagittal balance in degenerative spondylolisthesis, and are the first to consider the therapeutic implications this may have. 47 Meanwhile, Simmonds et al have developed the

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