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Tommaso Bonanzinga Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Matteo Carlo Ferrari Humanitas Clinical and Research Center, Milan, Italy

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Piergiuseppe Tanzi IRCCS Istituto Ortopedico Rizzoli; Università di Bologna, Dipartimento Scienze Biomediche e Neuromotorie, Bologna, Italy

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Filippo Vandenbulcke Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Akos Zahar Helios ENDO-Klinik, Hamburg, Germany

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Maurilio Marcacci Humanitas University, Department of Biomedical Sciences, Milan, Italy
Humanitas Clinical and Research Center, Milan, Italy

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Introduction Prosthetic joint infections (PJI) occur in 0.7% to 2.4% of patients and are responsible for 15% of failed total hip arthroplasties and 25% of revision total knee arthroplasties. 1 , 2 Almost any microorganism can cause PJI

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Martin McNally The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Irene Sigmund The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Austria

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Andrew Hotchen The Bone infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Ricardo Sousa Porto Bone and Joint Infection Group (GRIP), Department of Orthopaedics, Centro Hospitalar Universitario Santo António and CUF-Hospitais e Clinicas, Portugal

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Introduction Prosthetic joint infection (PJI) has been identified as the second most common cause of revision after knee arthroplasty and the fourth commonest cause in hips, in the United Kingdom ( 1 ). This may be a major underestimation as

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Donald J. Davidson Research Department of Orthopaedics and Musculoskeletal Sciences, University College London, London, UK
Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK

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David Spratt Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK

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Alexander D. Liddle Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
MSK Lab, Imperial College London, London, UK

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Introduction Prosthetic joint infection (PJI) is one of the most feared complications of arthroplasty surgery due to its resistance to therapy with existing antibiotics. 1 It is a major cause of failure in arthroplasty, being the leading

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Yangqi Xu Department of Surgery, Melbourne Medical School, University of Melbourne, Victoria, Melbourne, Australia

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Tony B Huang Department of Surgery, Melbourne Medical School, University of Melbourne, Victoria, Melbourne, Australia

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Michael A Schuetz Jamieson Trauma Institute, Metro North Hospital and Health Service, Queensland Health, Brisbane, Queensland, Australia
Department of Orthopaedic Surgery, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia
Queensland University of Technology (QUT), Brisbane, Queensland, Australia

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Peter F M Choong Department of Surgery, Melbourne Medical School, University of Melbourne, Victoria, Melbourne, Australia
Department of Orthopaedics, St. Vincent’s Hospital, Fitzroy, Victoria, Australia

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the ICARAUS group
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the ICARAUS group

Introduction Prosthetic joint infection (PJI) is one of the most devastating post-surgical complications for a patient undergoing a total joint arthroplasty (TJA). As one of the leading causes of joint replacement failure, PJI causes implant

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Pablo A. Slullitel Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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José I. Oñativia Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Martin A. Buttaro Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Marisa L. Sánchez Infectology Department, Italian Hospital of Buenos Aires, Argentina

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Fernando Comba Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Gerardo Zanotti Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Francisco Piccaluga Hip Surgery Unit, Italian Hospital of Buenos Aires, Argentina

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Introduction Being the third most common cause of revision surgery following primary total hip arthroplasty (THA), peri-prosthetic joint infection (PJI) constitutes one of the most undesired complications, with a prevalence of 0.3% to 2

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Theofilos Karachalios Department of Orthopaedics and Musculoskeletal Trauma, University General Hospital of Larissa, Greece
School of Health Sciences, Faculty of Medicine, University of Thessalia, Larissa, Greece

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George A. Komnos Department of Orthopaedics and Musculoskeletal Trauma, University General Hospital of Larissa, Greece

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Introduction Prosthetic joint infection (PJI) represents one of the most devastating complications in joint arthroplasty, with a prevalence of 1–2% after primary joint replacement and 4% after revision. 1 , 2 It is also the most common

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Andy Craig Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK

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S W King Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK

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B H van Duren Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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V T Veysi Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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S Jain Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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J Palan Department of Trauma & Orthopaedics, Leeds Teaching Hospitals, Leeds, UK
Leeds Institute of Rheumatic Musculoskeletal Medicine (LIRMM), Chapel Allerton Hospital, Leeds, UK

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Joint Registry (NJR) data indicating 10-year revision rates of approximately 2% for a number of commonly used prostheses ( 6 ). Nonetheless, prosthetic joint infection (PJI) remains a devastating complication. Of all single- and first-stage revisions (of

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Jaime Esteban Servicio de Microbiología Clínica, Hospital Universitario Fundación Jiménez Díaz-IIS-Fundacion Jimenez Diaz, Universidad Autónoma de Madrid, Madrid, Spain

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Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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Introduction Orthopaedic prosthetic joint infection (PJI) is a specific type of infection related to joint replacement and associated with biofilm formation on the surface of the inert implant. With an overall incidence between 1% and 5

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Michael de Buys Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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Krisantha Moodley Emergency Department, ER Consulting, Johannesburg, South Africa

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Josip Nenad Cakic Department Orthopaedic Surgery, Life Fourways Hospital, Johannesburg, South Africa

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Jurek R T Pietrzak Orthopaedic Surgery, University of Witswatersrand, Johannesburg, South Africa

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35 3353 – 3363 . ( https://doi.org/10.1016/j.arth.2020.05.074 ) 32600816 2. Ahmed SS & Haddad FS . Prosthetic joint infection . Bone and Joint Research 2019 8 570 – 572 . ( https://doi.org/10.1302/2046-3758.812.BJR-2019-0340 ) 31832177 3

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Ricardo Sousa Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal
Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal

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André Carvalho Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Ana Cláudia Santos Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Miguel Araújo Abreu Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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best practices for obtaining adequate samples in the most frequent clinical scenarios: (a) native and prosthetic joint infections; (b) osteomyelitis and fracture-related infections; (c) spinal infections and; (d) diabetic foot infections. Although a

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