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performed using the Medline, EMBASE and Cochrane Reviews databases for all papers published between 1978 and 2019 containing the following key terms: “platelet-rich plasma” AND “orthopaedics” AND (“classification” OR “mechanism of action” OR “preparation” OR
Walsall Manor Hospital, Moat Road, Walsall, WS2 9PS, UK
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Walsall Manor Hospital, Moat Road, Walsall, WS2 9PS, UK
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Introduction Platelet-rich plasma (PRP) has been used since the 1950s to manage maxillofacial and dermatological conditions. 1 , 2 The use of biological agents including PRP and mesenchymal stem cells (MSCs) in orthopaedics has increased
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Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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Academy of Orthopaedic Surgeons (AAOS) ( 20 ) include intra-articular CS injections among the options to manage patients affected by knee OA. On the other side, the use of hyaluronic acid (HA) and platelet-rich plasma (PRP) for knee OA patients is more
University of Basel, Basel, Switzerland
Swiss Orthopaedics, Grandvaux, Switzerland
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University of Basel, Basel, Switzerland
Department of Orthopedic Surgery, Division of Shoulder and Elbow, Mayo Clinic, Rochester, Minnesota
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Introduction Platelet-rich plasma (PRP) is a platelet concentrate (PC) derived from autologous blood which contains a three to ten times higher concentration of platelets than normal peripheral blood (150 000–350 000 platelets/μL) ( 1 , 2
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
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Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan
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Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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, hyaluronic acids, platelet-rich plasma (PRP), platelet rich in growth factor (PRGF), botulinum toxin A, O 2 –O 3 , dextrose, and mesenchymal stem cell (MSC). Regarding exercise, most studies included resistance training programs to strengthen the quadriceps
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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First Moscow State Medical University – Sechenov University, Moscow, Russia
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IRCCS Humanitas Research Hospital, Milan, Italy
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products we include corticosteroids (CS), hyaluronic acid (HA), polynucleotides, oxygen-ozone therapy, platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs). CS and HA are ranked first as the most frequently injected substances and their use is
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months from diagnosis. Podesta et al 29 recently reported improved results using platelet-rich plasma (PRP) in a series of partial MUCL tears. In our review of a series of 25 athletes with significant injuries to the proximal or distal end of the
IRCCS Galeazzi Orthopedic Institute, Milan, Italy
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IRCCS Galeazzi Orthopedic Institute, Milan, Italy
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of large bone defects. So far, demineralised bone matrix (DBM), platelet-rich plasma (PRP), MSCs and BMPs have been tested in addition to grafts and substitutes. Demineralised bone matrix DBM is essentially the proteinaceous component of bone
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, 104 However, in central tears its rate of success diminishes, probably influenced by the fact that healing in the inner third is different from the peripheral zone. 97 Platelet rich plasma Platelet rich plasma (PRP) is obtained from
Steadman Clinic and United States Coalition for the Prevention of Illness and Injury in Sport, Vail, Colorado, USA
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Steadman Clinic and United States Coalition for the Prevention of Illness and Injury in Sport, Vail, Colorado, USA
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platelet-rich plasma (PRP) or bone marrow aspirate concentrate (BMAC) being investigated throughout medicine and orthopedics as a source of healing ( 28 , 29 , 30 , 31 ). PRP is produced from peripheral blood by centrifugation to separate and concentrate
