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Nicolas de l’Escalopier Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France
Service de Chirurgie Orthopédique, Traumatologie et Chirurgie Réparatrice des Membres, Hôpital d’Instruction des Armées Percy, France

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Marjorie Salga Service de médecine physique et réadaptation, Hôpital Raymond Poincaré, France

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Laure Gatin Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France

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François Genêt Service de médecine physique et réadaptation, Hôpital Raymond Poincaré, France

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Philippe Denormandie Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France

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  • Traumatic neurological lesions may lead to development of heterotopic ossification. These cases are classified as ‘neurogenic heterotopic ossifications’ (NHOs). The associated neurological lesions can be caused by cranial trauma or spinal cord injury and may sometimes include a local trauma.

  • NHOs that form around the hip joints are of particular interest because they often cause the patient to avoid the sitting position or the resumption of walking.

  • Whilst NHO can involve the knee, shoulder and elbow joints, hip-involving NHOs are more numerous, and sometimes develop in close contact with vascular or neurological structures.

  • Multi-disciplinary clinical examination is fundamental to evaluate patients for surgical intervention and to define the objectives of the surgery. The best investigation to define an NHO mass is a computerized tomography (CT) scan.

  • Resection is performed to liberate a fused joint to provide functionality, and this need not be exhaustive if it is not necessary to increase the range of motion.

  • While recurrence does occur post-surgery, a partial resection does not pose a greater risk of recurrence and there are no adjuvant treatments available to reduce this risk.

  • The greatest risks associated with NHO surgical resection are infection and haematoma; these risks are very high and must be considered when evaluating patients for surgery.

Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180098

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Olga D. Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Panagiotis Koutsouradis Department of Orthopaedic Surgery, 417 Veterans Hospital (NIMTS), Athens, Greece

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George D. Chloros First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Ioannis Papanastasiou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Thomas Sarlikiotis First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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Aggelos Kaspiris Laboratory of Molecular Pharmacology/ Sector for Bone Research, School of Health Sciences, University of Patras, Patras, Greece

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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘ATTIKON’ Hospital, Athens, Greece

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, a pathologist, an oncologist, a vascular surgeon, and a plastic surgeon. Nowadays, benign tumours around the elbow such as juxta-articular osteoid osteoma (ΟΟ) can be treated with minimally invasive techniques such as CT-guided percutaneous

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Hagen Fritzsche University Center for Orthopaedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse, Dresden, Germany

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Anne Weidlich University Center for Orthopaedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse, Dresden, Germany

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Klaus-Dieter Schaser University Center for Orthopaedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse, Dresden, Germany

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Elisabeth Mehnert University Center for Orthopaedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse, Dresden, Germany

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Doreen Winkler University Center for Orthopaedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse, Dresden, Germany

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Stefan Rammelt University Center for Orthopaedics, Trauma and Plastic Surgery, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse, Dresden, Germany

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-inflammatory drugs (NSAIDs) can be an indication for the presence of an osteoid osteoma ( 13 , 14 ). Due to the absence of pain, fractures or other symptoms and the low prevalence of some tumours in the foot and ankle, diagnosis is frequently delayed ( 3 , 4 , 15

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Marta Salom Department of Pediatric Orthopedic, La Fe University and Polytechnique Hospital, Valencia, Spain

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Inês Balacó Department of Pediatric Orthopedic, Hospital Pediátrico de Coimbra, Unidade Local de Saúde de Coimbra, Portugal

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examination must be carried out including observation of the child’s gait, skin changes, and deformities. Scoliosis or kyphosis frequently develop in children with spine tumours in response to pain, very typical in osteoid osteoma and osteoblastoma, or

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James Plant Royal National Orthopaedic Hospital, Stanmore, UK

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Stephen Cannon Royal National Orthopaedic Hospital, Stanmore, UK

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lesion may not normally elicit a response from the bone or periosteum. Some lesions, such as osteoid osteoma, may cause a solid thickening of the bone around them. Tumours which are rapidly increasing in size give the most impressive and characteristic

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Olga Savvidou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Olympia Papakonstantinou Second Department of Radiology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Eleftheria Lakiotaki First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
These authors contributed equally to this manuscript

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Ioannis Zafeiris First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Dimitra Melissaridou First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece

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Pinelopi Korkolopoulou First Department of Pathology, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece
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Panayiotis J. Papagelopoulos First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece
Co-senior authors

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and cartilage. 1 – 4 Osseous surface bone tumours include benign tumours such as osteoma, osteoid osteoma and osteoblastoma, and the malignant category of surface osteosarcomas (parosteal, periosteal and high-grade osteosarcoma), while the

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G. Ulrich Exner Orthopaedie Zentrum Zuerich (ozz), Seestrasse 259, CH 8038 Zurich, Switzerland

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Michael O. Kurrer Gemeinschaftspraxis fuer Pathologie, Caecilienstrasse 3, CH 8032 Zurich, Switzerland

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Nadja Mamisch-Saupe Klinik Hirslanden, Department of Musculoskeletal Radiology, Witellikerstrasse 40, 8032 Zurich, Switzerland

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Stephen R. Cannon BMI The Clementine Churchill Hospital, Sudbury Hill, Harrow, Middlesex HA1 3RX, Great Britain

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, such as non-ossifying fibroma, fibrous dysplasia and osteoma, do not require a biopsy and biopsy of such lesions may even be misleading and distracting for the pathologist. As part of this hypothesis, the following questions should be discussed

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E. Mascard Necker University Hospital, 75015 Paris, France.

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N. Gaspar Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France

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L. Brugières Department of Pediatrics, Institute Gustave Roussy, 94805 Villejuif, France

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C. Glorion Orthopedic Surgery Department, Necker University Hospital, 149 rue de Sèvres, 75015 Paris, France

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S. Pannier Orthopedic Surgery Department, Necker University Hospital, 149 rue de Sèvres, 75015 Paris, France

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A. Gomez-Brouchet Laboratoire d'anatomie et cytologie pathologiques, Institut Universitaire du Cancer de Toulouse- Oncopole, 1 avenue Irène Joliot-Curie. 31059 Toulouse Cedex 9, France

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fatigue fractures, osteoarthritis or benign lesions such as osteoid osteoma. In soft-tissue tumours, it can help to assess secondary bone involvement in aggressive lesions. 15 Diagnosis: the biopsy When? A biopsy is always necessary in the

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Andrea Angelini Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Ivan Bohacek Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Mihovil Plecko Department of Orthopaedic Surgery, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Salata, Zagreb, Croatia

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Carlo Biz Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giulia Trovarelli Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Mariachiara Cerchiaro Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Giuseppe Di Rubbo Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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Pietro Ruggieri Department of Orthopedics and Traumatology and Oncological Orthopedics, University of Padova, Italy

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, osteoid osteoma. Resection of distal fibula and soft tissue reconstruction A summary of patients treated with resection of the distal fibula and soft tissue reconstruction is presented in Table 2 ( 6 , 7 , 12 , 30 , 31 , 32 , 33

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