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Hsiao-Yi Cheng Department of Primary Care Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Chun-Wei Liang School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

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Yu-Hao Lee Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Timporn Vitoonpong Department of Rehabilitation, King Chulalongkorn Memorial Hospital, Bankok, Thailand

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Chun-De Liao Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan

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Shih-Wei Huang Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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, hyaluronic acids, platelet-rich plasma (PRP), platelet rich in growth factor (PRGF), botulinum toxin A, O 2 –O 3 , dextrose, and mesenchymal stem cell (MSC). Regarding exercise, most studies included resistance training programs to strengthen the quadriceps

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Giorgio Maria Calori ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Emilio Mazza ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Alessandra Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Simone Mazzola ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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Massimiliano Colombo ASST-Pini-CTO, University of Milan, Orthopaedic Reparative Surgery Department, Milan, Italy

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studies have shown the association between bone mesenchymal stem cells (BMSCs) and non-traumatic AVN, which might have resulted from the decreased number and minor proliferative activity of BMSCs containing osteoprogenitor cells in the FH. 36 - 38

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Enrique Gómez-Barrena Department of Orthopaedic Surgery and Traumatology, Hospital La Paz-IdiPaz, Universidad Autónoma de Madrid, Madrid, Spain

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Christian Ehrnthaller Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Germany

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( 12 ) and also a decrease in proliferation and differentiation of mesenchymal stem cells (MSCs) ( 13 ), which may suggest a systemic mesenchymal and osteogenic cell pool defect in patients sustaining this type of lesion. Those are the non-unions that

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Luca Pierannunzii Gaetano Pini Orthopedic Institute, Milan, Italy
IRCCS Galeazzi Orthopedic Institute, Milan, Italy

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Luigi Zagra Gaetano Pini Orthopedic Institute, Milan, Italy
IRCCS Galeazzi Orthopedic Institute, Milan, Italy

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is the passive ability of a scaffold to be progressively substituted by viable bone; osteoinductivity is the capacity to stimulate the osteoblastic differentiation of local adult stem cells (i.e. mesenchymal stem cells, MSCs) through specific growth

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Gerardo Fusco Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Francesco M. Gambaro Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors

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Berardo Di Matteo Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia

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Elizaveta Kon Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy

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products we include corticosteroids (CS), hyaluronic acid (HA), polynucleotides, oxygen-ozone therapy, platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs). CS and HA are ranked first as the most frequently injected substances and their use is

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Mukai Chimutengwende-Gordon Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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James Donaldson Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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George Bentley Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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stimulation is to penetrate the subchondral bone plate with an awl, allowing a fibrin clot containing mesenchymal stem cells to be produced in the defect. 11 The mesenchymal stem cells are able to differentiate into fibrochondrocytes, leading to

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Minghe Yao West China School of Medicine, Sichuan University, Chengdu, China

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Tingkui Wu Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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Beiyu Wang Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China

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#4 (‘pulposus-derived mesenchymal stem cell’; 88; 2015; S  = 0.879; Sakai & Andersson ( 72 )), the trend came into cluster #3 (‘interventional pain physician’; 126; 2017; S  = 0.807; Noriega et al. ( 43 )) while branching into two related clusters

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Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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the other 76% proposed the use of autologous cells. Treatments included percutaneously aspirated autologous bone marrow cells ( n = 1), pre-osteoblast cells from bone marrow ( n = 2), and mesenchymal stem cells from bone marrow ( n = 9). Two trials

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Fan Wu Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig-Maximilians-University (LMU), Munich, Germany

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Michael Nerlich Department of Trauma Surgery, University Regensburg Medical Center, Regensburg, Germany

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Denitsa Docheva Experimental Trauma Surgery, Department of Trauma Surgery, University Regensburg Medical Center, Regensburg, Germany and Department of Medical Biology, Medical University-Plovdiv, Plovdiv, Bulgaria

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elucidated Kohler at al 30 Bi et al 31 Perivascular cell Pericyte Tendon mesenchymal stem cell (TMSC) Vessel, paratenon, epitenon, tendon sheets Regulation of stem cells; regeneration of various tissues; immunomodulation Tempfer et al

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Felix Christoph Finger BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Steffen Schröter Diakonie Klinikum Jung-Stilling GmbH, Department of Trauma and Reconstructive Surgery, Siegen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany

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Christoph Ihle BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Moritz Herbst BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Tina Histing BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Marc-Daniel Ahrend BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany
AO Research Institute Davos, Davos, Switzerland

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joint to enable regeneration or preservation of cartilage tissue. The injection of mesenchymal stem cells (MSCs) to support cartilage regeneration was analyzed by Jin et al. in a systematic review ( 8 ). It showed that MSC injection following HTO

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