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Mark Anthony Roussot Department of Trauma and Orthopaedics, University College London Hospitals, London, UK
Department of Orthopaedic Surgery, University of Cape Town, South Africa

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Georges Frederic Vles Department of Trauma and Orthopaedics, University College London Hospitals, London, UK

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Sam Oussedik Department of Trauma and Orthopaedics, University College London Hospitals, London, UK

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floor during single leg stance. 5 Insall, on the other hand, focussed on restoring neutral mechanical alignment (MA) with orthogonal femoral and tibial resections, subsequently balancing flexion and extension gaps with soft tissue releases ( Fig. 1

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Timothy Lording Melbourne Orthopaedic Group and The Alfred Hospital, Australia

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Sébastien Lustig Albert Trillat Center, Groupement Hospitalier Nord, Université Lyon 1, France

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Philippe Neyret Albert Trillat Center, Groupement Hospitalier Nord, Université Lyon 1, France

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view that residual varus of femoral origin was acceptable, but neutral mechanical alignment of the tibial component was mandatory. 1 More recently, a number of authors have challenged this principle, suggesting “malalignment” of the mechanical axis

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Geert Meermans Bravis Hospital, Roosendaal, The Netherlands

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George Grammatopoulos The Ottawa Hospital, Ottawa, Ontario, Canada

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Moritz Innmann Heidelberg University Hospital, Heidelberg, Germany

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David Beverland Belfast Health and Social Care Trust, Belfast, UK

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on the presumption that it is easier for surgeons to evaluate a 90° angle than a 45° angle. These mechanical alignment guides are limited in that they can only achieve one target angle and lack accuracy ( 16 , 17 , 71 ). When operating with the

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Sohail Nisar Leeds Institute of Rheumatic and Musculoskeletal Medicine, UK
Academic Department of Trauma and Orthopaedics, LGI, University of Leeds, Leeds, UK
Leeds Teaching Hospitals Trust, UK

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Jeya Palan Leeds Teaching Hospitals Trust, UK

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Charles Rivière MSK Lab - Imperial College London, White City Campus, London, UK
The Lister Hospital, Chelsea Bridge, London, UK
Centre de l’Arthrose - Clinique du Sport, Bordeaux-Mérignac, France

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Mark Emerton Leeds Teaching Hospitals Trust, UK

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Hemant Pandit Leeds Institute of Rheumatic and Musculoskeletal Medicine, UK
Leeds Teaching Hospitals Trust, UK

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need for further intervention and early revision surgery. 7 Such wear is unlikely to occur with modern-day polyethylene and implants. A study by Yeo et al comparing AA with mechanical alignment (MA) showed comparable clinical, radiological and

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Ahmed Siddiqi Cleveland Clinic Foundation, Department of Orthopedics Cleveland, Ohio, USA

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Timothy Horan Philadelphia College of Osteopathic Medicine, Department of Orthopedics, Philadelphia, Pennsylvania, USA

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Robert M. Molloy Cleveland Clinic Foundation, Department of Orthopedics Cleveland, Ohio, USA

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Michael R. Bloomfield Cleveland Clinic Foundation, Department of Orthopedics Cleveland, Ohio, USA

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Preetesh D. Patel Cleveland Clinic Florida, Department of Orthopedics, Weston, Florida, USA

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Nicolas S. Piuzzi Cleveland Clinic Foundation, Department of Orthopedics Cleveland, Ohio, USA

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studies with a total of 577 knees undergoing TKA were included. Compared with conventional surgery, active robotic TKA showed better outcomes in precise mechanical alignment (p < 0.05) and implant position, with lower outliers (p < 0.05), better functional

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Theofilos Karachalios School of Health Sciences, Faculty of Medicine, University of Thessalia, Greece
Orthopaedic Department, University General Hospital of Larissa, Greece

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George A. Komnos Orthopaedic Department, University General Hospital of Larissa, Greece

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and the differences between dynamic and static loading conditions. 19 , 21 , 22 In mechanical alignment, osteotomy in the frontal plane is designed in such a way that the mechanical axis falls upon the centre of the knee joint in order to reduce

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Charles Rivière Imperial College London, UK; South West London Elective Orthopaedic Centre, UK

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Stefan Lazic South West London Elective Orthopaedic Centre, UK

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Oliver Boughton Imperial College London, UK

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Yann Wiart Theresienkrankenhauss Mannheim, Germany

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Loic Vïllet Centre de l’arthrose, Mérignac, France

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Justin Cobb Imperial College London, UK

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and other improvements such as better wear-resistance with modern polyethylene and better cementation, some authors have started to challenge the basics of the mechanical alignment (MA) technique and recently developed and tested more anatomy

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Charles Rivière Clinique du Sport, Bordeaux-Mérignac, France
Personalized Arthroplasty Society, Atlanta, Georgia, USA

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William Jackson Personalized Arthroplasty Society, Atlanta, Georgia, USA
Nuffield Orthopaedic Centre, Headington, Oxford, UK

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Loïc Villet Clinique du Sport, Bordeaux-Mérignac, France
Personalized Arthroplasty Society, Atlanta, Georgia, USA

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Sivan Sivaloganathan Personalized Arthroplasty Society, Atlanta, Georgia, USA
South-West London Elective Orthopaedic Centre, Epsom, UK

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Yaron Barziv Personalized Arthroplasty Society, Atlanta, Georgia, USA
Shamir Medical Center, Zriffin, Israel

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Pascal-André Vendittoli Personalized Arthroplasty Society, Atlanta, Georgia, USA
Département de Chirurgie, Université de Montréal, Hôpital Maisonneuve-Rosemont, Montréal, Québec, Canada

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reduces the extent of soft tissue releases compared to more traditional mechanical alignment surgery. 10 , 11 In a study assessing 4884 lower limb computerized tomography (CT) scans of patients scheduled for TKA (performed with patient

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Pascal-André Vendittoli Personalized Arthroplasty Society
Surgery Department, Hôpital Maisonneuve-Rosemont, Montreal University, Montreal, Québec, Canada
Clinique orthopédique Duval, 1487 Boul des Laurentides, Laval

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Charles Riviere Personalized Arthroplasty Society
Bordeaux Arthroplasty Research Institute - Clinique du Sport Bordeaux-Mérignac 04-06 rue Georges Negrevergne, Mérignac, France

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Michael T Hirschmann Personalized Arthroplasty Society
Department of Orthopedic Surgery and Traumatology, Kantonsspital Baselland, Bruderholz, Switzerland
Clinical Research Group Michael T. Hirschmann, Regenerative Medicine & Biomechanics, University of Basel, Basel, Switzerland

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Stefano Bini Personalized Arthroplasty Society
Department of Surgery, University of California, San Francisco, California, USA

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. Knee replacement To simplify TKA operations, surgeons selected neutral femoral and tibial cuts to create rectangular flexion and extension gaps and a neutral mechanical axis. Codified under ‘mechanical alignment’, these targets were considered

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Charles Rivière MSK Lab, Imperial College London, UK; South West London Elective Orthopaedic Center, UK

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Stefan Lazic South West London Elective Orthopaedic Center, UK

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Loïc Villet Centre de l’arthrose, Merignac, France

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Yann Wiart Unfallchirurgie, Theresienkrankenhauss Mannheim, Germany

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Sarah Muirhead Allwood London Hip Unit, UK

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Justin Cobb MSK Lab, Imperial College London, UK

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technique for TKA For decades, knee components have been positioned following the concept of mechanical alignment (MA), where implants are aligned perpendicular to the femoral and tibial mechanical axes in order to create a straight lower limb with a

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