Hsiao-Yi Cheng
Hsiao-Yi Cheng
Department of Primary Care Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for other papers by Hsiao-Yi Cheng in
Google Scholar
PubMed
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for other papers by Hsiao-Yi Cheng in
Google Scholar
PubMed
Chun-Wei Liang
Chun-Wei Liang
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Search for other papers by Chun-Wei Liang in
Google Scholar
PubMed
Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Search for other papers by Chun-Wei Liang in
Google Scholar
PubMed
Yu-Hao Lee
Yu-Hao Lee
Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for other papers by Yu-Hao Lee in
Google Scholar
PubMed
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for other papers by Yu-Hao Lee in
Google Scholar
PubMed
Timporn Vitoonpong
Timporn Vitoonpong
Department of Rehabilitation, King Chulalongkorn Memorial Hospital, Bankok, Thailand
Search for other papers by Timporn Vitoonpong in
Google Scholar
PubMed
Search for other papers by Timporn Vitoonpong in
Google Scholar
PubMed
Chun-De Liao
Chun-De Liao
Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan
Search for other papers by Chun-De Liao in
Google Scholar
PubMed
Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan
Search for other papers by Chun-De Liao in
Google Scholar
PubMed
Shih-Wei Huang
Shih-Wei Huang
Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for other papers by Shih-Wei Huang in
Google Scholar
PubMed
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Search for other papers by Shih-Wei Huang in
Google Scholar
PubMed
Introduction Knee osteoarthritis is a common cause of disability in older adults. Current treatment strategies for knee osteoarthritis can be classified as surgical and non-surgical interventions. Total knee arthroplasty is an effective
Julien Favre
Julien Favre
Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Search for other papers by Julien Favre in
Google Scholar
PubMed
Search for other papers by Julien Favre in
Google Scholar
PubMed
Brigitte M. Jolles
Brigitte M. Jolles
Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Search for other papers by Brigitte M. Jolles in
Google Scholar
PubMed
Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Search for other papers by Brigitte M. Jolles in
Google Scholar
PubMed
tissues are primarily conditioned by cyclic loading and gait is the primary load-bearing activity, particularly with knee and OA. Fig. 1 Quantifying three-dimensional ambulatory biomechanics is critical to understand knee osteoarthritis. Combining
Alessandro Bensa
Alessandro Bensa
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Search for other papers by Alessandro Bensa in
Google Scholar
PubMed
Search for other papers by Alessandro Bensa in
Google Scholar
PubMed
Alessandro Sangiorgio
Alessandro Sangiorgio
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Search for other papers by Alessandro Sangiorgio in
Google Scholar
PubMed
Search for other papers by Alessandro Sangiorgio in
Google Scholar
PubMed
Angelo Boffa
Angelo Boffa
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Search for other papers by Angelo Boffa in
Google Scholar
PubMed
Search for other papers by Angelo Boffa in
Google Scholar
PubMed
Manuela Salerno
Manuela Salerno
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Search for other papers by Manuela Salerno in
Google Scholar
PubMed
Search for other papers by Manuela Salerno in
Google Scholar
PubMed
Giacomo Moraca
Giacomo Moraca
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Search for other papers by Giacomo Moraca in
Google Scholar
PubMed
Search for other papers by Giacomo Moraca in
Google Scholar
PubMed
Giuseppe Filardo
Giuseppe Filardo
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
Search for other papers by Giuseppe Filardo in
Google Scholar
PubMed
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
Search for other papers by Giuseppe Filardo in
Google Scholar
PubMed
Introduction Knee osteoarthritis (OA) is one of the most common orthopedic diseases and represents a major cause of knee pain and disability in older adults ( 1 , 2 ). The prevalence of this degenerative condition is currently rising, with a
Serkan Bayram
Serkan Bayram
Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Search for other papers by Serkan Bayram in
Google Scholar
PubMed
Search for other papers by Serkan Bayram in
Google Scholar
PubMed
Ahmet Salduz
Ahmet Salduz
Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Search for other papers by Ahmet Salduz in
Google Scholar
PubMed
Search for other papers by Ahmet Salduz in
Google Scholar
PubMed
Ahmet Müçteba Yıldırım
Ahmet Müçteba Yıldırım
Department of Orthopedics and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Search for other papers by Ahmet Müçteba Yıldırım in
Google Scholar
PubMed
Search for other papers by Ahmet Müçteba Yıldırım in
Google Scholar
PubMed
Korhan Özkan
Korhan Özkan
Department of Orthopedics and Traumatology, Istanbul Medeniyet University, Istanbul Faculty of Medicine, Istanbul, Turkey
Search for other papers by Korhan Özkan in
Google Scholar
PubMed
Search for other papers by Korhan Özkan in
Google Scholar
PubMed
Levent Eralp
Levent Eralp
Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Search for other papers by Levent Eralp in
Google Scholar
PubMed
Search for other papers by Levent Eralp in
Google Scholar
PubMed
Harzem Özger
Harzem Özger
Department of Orthopedics and Traumatology, Retired Professor of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Search for other papers by Harzem Özger in
Google Scholar
PubMed
Search for other papers by Harzem Özger in
Google Scholar
PubMed
surgery has been reported in the literature ( 9 ). Extended curettage and full filling with bone cement for aggressive bone tumor around the knee is also associated with knee osteoarthritis ( 9 ). The hyperthermic polymerization of PMMA may cause damage to
Di Zhao
Di Zhao
The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Search for other papers by Di Zhao in
Google Scholar
PubMed
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Search for other papers by Di Zhao in
Google Scholar
PubMed
Ling-feng Zeng
Ling-feng Zeng
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Search for other papers by Ling-feng Zeng in
Google Scholar
PubMed
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Search for other papers by Ling-feng Zeng in
Google Scholar
PubMed
Gui-hong Liang
Gui-hong Liang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Search for other papers by Gui-hong Liang in
Google Scholar
PubMed
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Search for other papers by Gui-hong Liang in
Google Scholar
PubMed
Jian-ke Pan
Jian-ke Pan
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for other papers by Jian-ke Pan in
Google Scholar
PubMed
Search for other papers by Jian-ke Pan in
Google Scholar
PubMed
Ming-hui Luo
Ming-hui Luo
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for other papers by Ming-hui Luo in
Google Scholar
PubMed
Search for other papers by Ming-hui Luo in
Google Scholar
PubMed
Yan-hong Han
Yan-hong Han
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for other papers by Yan-hong Han in
Google Scholar
PubMed
Search for other papers by Yan-hong Han in
Google Scholar
PubMed
Jun Liu
Jun Liu
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for other papers by Jun Liu in
Google Scholar
PubMed
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for other papers by Jun Liu in
Google Scholar
PubMed
Wei-yi Yang
Wei-yi Yang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Search for other papers by Wei-yi Yang in
Google Scholar
PubMed
Search for other papers by Wei-yi Yang in
Google Scholar
PubMed
Block JA . The relationship of vibratory perception to dynamic joint loading, radiographic severity, and pain in knee osteoarthritis . Arthritis and Rheumatism 2012 64 181 – 186 . ( https://doi.org/10.1002/art.30657 ) 11. Hochberg MC Tive LA
Gerardo Fusco
Gerardo Fusco
Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
Search for other papers by Gerardo Fusco in
Google Scholar
PubMed
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
Search for other papers by Gerardo Fusco in
Google Scholar
PubMed
Francesco M. Gambaro
Francesco M. Gambaro
Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
Search for other papers by Francesco M. Gambaro in
Google Scholar
PubMed
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
Search for other papers by Francesco M. Gambaro in
Google Scholar
PubMed
Berardo Di Matteo
Berardo Di Matteo
Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia
Search for other papers by Berardo Di Matteo in
Google Scholar
PubMed
First Moscow State Medical University – Sechenov University, Moscow, Russia
Search for other papers by Berardo Di Matteo in
Google Scholar
PubMed
Elizaveta Kon
Elizaveta Kon
Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
Search for other papers by Elizaveta Kon in
Google Scholar
PubMed
IRCCS Humanitas Research Hospital, Milan, Italy
Search for other papers by Elizaveta Kon in
Google Scholar
PubMed
. 2. Mora JC Przkora R Cruz-Almeida Y . Knee osteoarthritis: pathophysiology and current treatment modalities . J Pain Res 2018 ; 11 : 2189 – 2196 . 3. Nelson AE Allen KD Golightly YM
Tommaso Bonanzinga
Tommaso Bonanzinga
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Tommaso Bonanzinga in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Tommaso Bonanzinga in
Google Scholar
PubMed
Pietro Conte
Pietro Conte
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Pietro Conte in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Pietro Conte in
Google Scholar
PubMed
Giuseppe Anzillotti
Giuseppe Anzillotti
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Giuseppe Anzillotti in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Giuseppe Anzillotti in
Google Scholar
PubMed
Vincenzo Longobardi
Vincenzo Longobardi
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Vincenzo Longobardi in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Vincenzo Longobardi in
Google Scholar
PubMed
Elizaveta Kon
Elizaveta Kon
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia
Search for other papers by Elizaveta Kon in
Google Scholar
PubMed
Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia
Search for other papers by Elizaveta Kon in
Google Scholar
PubMed
Maria Rescigno
Maria Rescigno
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maria Rescigno in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maria Rescigno in
Google Scholar
PubMed
Maurilio Marcacci
Maurilio Marcacci
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maurilio Marcacci in
Google Scholar
PubMed
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
Search for other papers by Maurilio Marcacci in
Google Scholar
PubMed
). Extensive research on the PubMed, Cochrane, and Google Scholar databases was performed on July 15, 2023, using the following words: (microbiome OR microbiota OR bacteria) AND (knee osteoarthritis OR knee OA). The screening process and analysis were conducted
E Carlos Rodríguez-Merchán
E Carlos Rodríguez-Merchán
Department of Orthopaedic Surgery, La Paz University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
Search for other papers by E Carlos Rodríguez-Merchán in
Google Scholar
PubMed
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
Search for other papers by E Carlos Rodríguez-Merchán in
Google Scholar
PubMed
). Convolutional neural networks CNNs can identify and classify knee osteoarthritis as accurately as a fellowship-trained orthopedic surgeon According to Schwartz et al. , the use of a CNN to classify osteoarthritis severity could significantly reduce
Elena Gálvez-Sirvent
Elena Gálvez-Sirvent
Department of Orthopaedic Surgery, “Infanta Elena” University Hospital, Valdemoro, Madrid, Spain
Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain
Search for other papers by Elena Gálvez-Sirvent in
Google Scholar
PubMed
Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain
Search for other papers by Elena Gálvez-Sirvent in
Google Scholar
PubMed
Aitor Ibarzábal-Gil
Aitor Ibarzábal-Gil
Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain
Search for other papers by Aitor Ibarzábal-Gil in
Google Scholar
PubMed
Search for other papers by Aitor Ibarzábal-Gil in
Google Scholar
PubMed
E Carlos Rodríguez-Merchán
E Carlos Rodríguez-Merchán
Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
Search for other papers by E Carlos Rodríguez-Merchán in
Google Scholar
PubMed
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain
Search for other papers by E Carlos Rodríguez-Merchán in
Google Scholar
PubMed
trigger a malunion of the fracture, resulting in knee osteoarthritis or alteration of the mechanical axis of the lower limb. A suboptimal result after surgery justifies early re-osteosynthesis, otherwise, the result will inevitably be malunion ( 89 ). No
Mattia Alessio-Mazzola
Mattia Alessio-Mazzola
IRCCS Ospedale San Raffaele, Unità Clinica di Ortopedia e Traumatologia, Via Olgettina, Milan, Italy
Search for other papers by Mattia Alessio-Mazzola in
Google Scholar
PubMed
Search for other papers by Mattia Alessio-Mazzola in
Google Scholar
PubMed
Giacomo Placella
Giacomo Placella
Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy
Search for other papers by Giacomo Placella in
Google Scholar
PubMed
Search for other papers by Giacomo Placella in
Google Scholar
PubMed
Luigi Zagra
Luigi Zagra
Hip Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
Search for other papers by Luigi Zagra in
Google Scholar
PubMed
Search for other papers by Luigi Zagra in
Google Scholar
PubMed
Orlando Leone
Orlando Leone
Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy
Search for other papers by Orlando Leone in
Google Scholar
PubMed
Search for other papers by Orlando Leone in
Google Scholar
PubMed
Natasha Di Fabio
Natasha Di Fabio
Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy
Search for other papers by Natasha Di Fabio in
Google Scholar
PubMed
Search for other papers by Natasha Di Fabio in
Google Scholar
PubMed
Desiree Moharamzadeh
Desiree Moharamzadeh
IRCCS Ospedale San Raffaele, Unità Clinica di Ortopedia e Traumatologia, Via Olgettina, Milan, Italy
Search for other papers by Desiree Moharamzadeh in
Google Scholar
PubMed
Search for other papers by Desiree Moharamzadeh in
Google Scholar
PubMed
Vincenzo Salini
Vincenzo Salini
Università Vita-Salute San Raffaele, Via Olgettina, Milan, Italy
Search for other papers by Vincenzo Salini in
Google Scholar
PubMed
Search for other papers by Vincenzo Salini in
Google Scholar
PubMed
Introduction Anterior cruciate ligament (ACL) injury represents a well-recognized risk factor for the future development of knee osteoarthritis (OA) ( 1 ) as instability is a leading cause of cartilage and meniscal damage with a growing
