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Simon M. Lambert University College London Hospital, UK

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affecting fracture healing with a judgement about the likely prognosis for healing and function based on a multiplicity of intrinsic (shoulder) and extrinsic (comorbid) factors. For any displaced fracture treated nonoperatively, the outcome will be defined

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Paul L Rodham Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Vasileios P Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Nikolaos K Kanakaris Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland
Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland

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Peter V Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Introduction Bone grafting is a surgical procedure whereby bone tissue is transplanted from one area to another in order to repair or replace non-viable bone or augment the native healing response ( 1 ). Following blood transfusion, bone

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Signe Steenstrup Jensen Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

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Niels Martin Jensen Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark

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Per Hviid Gundtoft Department of Orthopedic Surgery and Traumatology, Aarhus University Hospital, Aarhus, Denmark

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Søren Kold Department of Orthopedic Surgery, Aalborg University Hospital, Aalborg, Denmark

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Robert Zura Department of Orthopedic Surgery, Louisiana State University Medical Center, New Orleans, Louisiana, USA

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Bjarke Viberg Department of Orthopedic Surgery and Traumatology, Lillebaelt Hospital, Kolding, Denmark
Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

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has failed to unite completely. Nonunion is usually established when a minimum of 9 months has elapsed since the injury and the fracture site has shown no, or minimal, progressive signs of healing for a minimum of 3 months’ ( 12 ). Therefore, a 9-month

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Pernille Bovbjerg Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark

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Ditte Høgh Department of Orthopedic Surgery, Hospital of Southern Denmark, Odense, Denmark

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Lonnie Froberg Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark

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Hagen Schmal Department of Orthopedic Surgery, Odense University Hospital, Odense, Denmark
Clinic of Orthopaedic Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

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Moustapha Kassem Department of Endocrinology, Odense University Hospital, Odense, Denmark

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stimulates bone formation by activating osteoblasts. PTH (1-84) has shown the same effect and has been used as an osteoporotic treatment as well. 5 This suggests a positive influence on bone healing, and teriparatide has been used off-label for treatment

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Maria-Pau Ginebra Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Montserrat Espanol Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain

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Yassine Maazouz Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), Spain
Mimetis Biomaterials, Spain

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Victor Bergez Mimetis Biomaterials, Spain

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David Pastorino Mimetis Biomaterials, Spain

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Bone as a living tissue: the bone healing process Bone composition: the role of bone mineral Bone is a metabolically active tissue, containing several types of cells in a unique extracellular matrix. A distinctive feature of the

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Enrique Gómez-Barrena Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Norma G. Padilla-Eguiluz Servicio de Cirugía Ortopédica y Traumatología, Hospital La Paz-IdiPAZ, Universidad Autónoma de Madrid, Madrid, Spain

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Philippe Rosset Service de Chirurgie Orthopédique et Traumatologie, CHU Tours, Université de Tours, Tours, France

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Introduction Non-union or pseudarthrosis represents the inability of bone to heal after a fracture. Although this is a general definition that is well accepted by most orthopaedic trauma surgeons, it is not a simple concept. The absence of

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Guo-xu Zhang Guangzhou University of Chinese Medicine, Guangzhou, China

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Ji Li Guangzhou University of Chinese Medicine, Guangzhou, China

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Qi-jun Xie Guangzhou University of Chinese Medicine, Guangzhou, China

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Mei-ren Zhang Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China

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Kui Zhao Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China

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Hai-yun Chen Guangdong Hospital of Traditional Chinese Medicine, Guangzhou, China

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, fracture healing time, range of motion (ROM) of the knee joint post-operation 6 months, overall excellent and good rates of Schatzker–Lambert functional score ( 20 ), and postoperative complications; (iv) randomised controlled trials and cohort studies; (v

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Elena Gálvez-Sirvent Department of Orthopaedic Surgery, “Infanta Elena” University Hospital, Valdemoro, Madrid, Spain
Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain

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Aitor Ibarzábal-Gil Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain

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E Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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). MUA is not free from complications such as fractures, implant failure with loss of reduction (in cases of very early mobilisation prior to fracture healing), tendon rupture, and articular cartilage damage ( 31 ). MUA should therefore be performed with

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Mustafa S. Rashid Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK

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Yves Tourné Institut Grenoblois de Chirurgie du Pied, Echirolles, France

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Kar H. Teoh Princess Alexandra Hospital, Harlow, UK

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fractures due to bone pathology or malignancy Accelerating repair in distraction osteogenesis procedures Treatment of joint fusion Source : Taken from Bioventus EXOGEN ® Ultrasound Bone Healing System Instruction Manual

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Vinzenz Auersperg Department of Orthopaedics, Klinikum Steyr-Kirchdorf, Steyr, Austria

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Klemens Trieb Department of Orthopaedic and Trauma Surgery, Paracelsus Medical University Salzburg, Salzburg, Austria
Computed Tomography Research Group, University of Applied Sciences Upper Austria, Wels, Austria

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cell vesicles, which release the specific proteins of the healing process. Wang’s research group showed several working mechanisms which fit into this idea of mechano-transduction, as the cascade is called by ESWT users. 15 In animal models it is

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