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2019 ; 18 : 1533033819840000 . 5. Xing R Yang J Kong Q Tu C Zhou Y Duan H . Giant cell tumour of bone in the appendicular skeleton: an analysis of 276 cases . Acta Orthop Belg 2013 ; 79
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Introduction Denosumab is a fully humanised monoclonal antibody of the RANK ligand (nuclear factor kappa B ligand) which inhibits the RANK–RANKL interaction. The mononuclear stromal cells of giant cell tumour of bone (GCTB) overexpress RANKL
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. Werner M . Giant cell tumour of bone: morphological, biological and histogenetical aspects . Int Orthop 2006 ; 30 : 484 – 489 . 30. Campanacci M Baldini N Boriani S Sudanese A . Giant-cell tumor of bone
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destructive growth. Giant cell tumours of bone Giant cell tumours (GCT) of bone are benign lesions that carry a high risk of pathologic fracture and recurrence. Moreover, malignant transformation is reported in up to 10% and systemic metastasis in 1
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Wadia F Chaudhary K Anchan C George S & Dhawale A . Metachronous multicentric giant cell tumour of bone in a 12-year-old girl: a case report and review of literature . Journal of Orthopaedics, Trauma and Rehabilitation 2021 28 . ( https