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Elizabeth K Tissingh The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
King’s Global Health Partnerships, School of Life Course and Population Sciences, King’s College London, London, UK

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Leonard Marais Department of Orthopaedic Surgery, School of Clinical Medicine, University of KwaZulu-Natal, KwaZulu-Natal, South Africa

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Antonio Loro Comprehensive Rehabilitation Services for People with Disability in Uganda (CoRSU) Hospital, Kisubi, Uganda

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Deepa Bose University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Nilo T Paner Department of Orthopaedics, University of the Philippines, Philippine General Hospital Manila, The Phillipines

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Jamie Ferguson The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
Department of Orthopaedics, University of the Philippines, Philippine General Hospital Manila, The Phillipines

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Mario Morgensten Centre for Musculoskeletal Infections, Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Basel, Switzerland

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Martin McNally The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Introduction and aims The global burden of fracture-related infection (FRI) is likely to be concentrated in countries with limited healthcare resources. Conditions associated with FRI (road injuries, other musculoskeletal disorders, falls and

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Martin McNally The Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Geertje Govaert Department of Trauma Surgery, University of Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands

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Maria Dudareva The Oxford Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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Mario Morgenstern Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Switzerland

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Willem-Jan Metsemakers Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium

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be confusing and do not give specific indication of the relationship with a fracture. The FRI Consensus Group published the initial definition criteria in 2018 8 and the term ‘fracture-related infection’ was adopted to encompass all infections

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Tristan Ferry Service de Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
Université Claude Bernard Lyon 1, Villeurbanne, France
Centre de Références des IOA Complexes de Lyon, CRIOAc Lyon, Lyon, France
StaPath team, Centre International de Recherche en Infectiologie, CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon, UCBL1, Lyon, France
Education and Clinical Officer of the ESCMID Study Group for Non-traditional Antibacterial Therapy (ESGNTA)

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Jolien Onsea Department of Trauma Surgery, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium

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Tiphaine Roussel-Gaillard Institut des Agents Infectieux, Centre de Biologie et de Pathologie du Nord, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

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Cécile Batailler Service de Chirurgie Orthopédique et de Médecine du Sport, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France

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Thomas Fintan Moriarty AO Research Institute Davos, Clavadelerstrasse 8, Davos Platz, Switzerland

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Willem-Jan Metsemakers Department of Trauma Surgery, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
Department of Development and Regeneration, KU Leuven, Oude Markt 13, Leuven, Belgium

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Introduction Musculoskeletal infections (MSIs), including periprosthetic joint infection (PJI) and fracture-related infection (FRI), remain a devastating complication in modern trauma and orthopaedic surgery, with significant financial and

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Sylvain Steinmetz Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Diane Wernly Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Kevin Moerenhout Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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Andrej Trampuz Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery (CMSC), Berlin, Germany

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Olivier Borens Service of Orthopaedics and Traumatology, Lausanne University Hospital, Lausanne, Switzerland

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infections (FRI) ( Table 1 ). 7 Table 1. Definition of infection after fracture-related infection, as proposed by Metsemakers et al. 7 Confirmatory criteria Fistula, sinus or wound breakdown (probe to bone or implant

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Ricardo Sousa Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal
Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal

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André Carvalho Department of Orthopaedics, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Ana Cláudia Santos Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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Miguel Araújo Abreu Porto Bone and Joint Infection Group (GRIP), Centro Hospitalar Universitário do Porto and Grupo TrofaSaude, Portugal
Department of Microbiology, Centro Hospitalar Universitário do Porto, Porto, Portugal

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best practices for obtaining adequate samples in the most frequent clinical scenarios: (a) native and prosthetic joint infections; (b) osteomyelitis and fracture-related infections; (c) spinal infections and; (d) diabetic foot infections. Although a

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Elena Gálvez-Sirvent Department of Orthopaedic Surgery, “Infanta Elena” University Hospital, Valdemoro, Madrid, Spain
Faculty of Medicine, Universidad Francisco de Vitoria, Madrid, Spain

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Aitor Ibarzábal-Gil Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain

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E Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, “La Paz” University Hospital, Madrid, Spain
Osteoarticular Surgery Research, Hospital La Paz Institute for Health Research – IdiPAZ (La Paz University Hospital – Autonomous University of Madrid), Madrid, Spain

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patients with fracture-related infection: a systematic review and critical appraisal . BioMed Research International 2021 2021 7742227. ( https://doi.org/10.1155/2021/7742227 ) 68. Jensen NM Steenstrup S Ravn C Schmal H Viberg B . The use of

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Joseph Genevière Faculty of Medicine, University of Geneva, Geneva, Switzerland
Co-first authors and equal contributors

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Shawna McCallin Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland
Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland
Co-first authors and equal contributors

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Angela Huttner Faculty of Medicine, University of Geneva, Geneva, Switzerland
Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland

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Truong-Thanh Pham Faculty of Medicine, University of Geneva, Geneva, Switzerland
Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland
Division of Orthopaedics and Trauma Surgery, Bone Infection Unit, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland

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Domizio Suva Faculty of Medicine, University of Geneva, Geneva, Switzerland
Division of Orthopaedics and Trauma Surgery, Bone Infection Unit, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland

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Introduction Bone and joint infections include any infection of the bone (osteomyelitis), joint (septic arthritis) or implants related to these structures (periprosthetic joint infections [PJI], fracture-related infections [FRI] involving

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Paul L Rodham Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Vasileios P Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Nikolaos K Kanakaris Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland
Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland

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Peter V Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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rapid resorption over a period of 4–12 weeks and can be combined with antibiotics increasing interest in these molecules where fracture-related infection is present ( 11 ). The most commonly encountered commercially available products include osteoset

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Elena Gálvez-Sirvent Department of Orthopaedic Surgery, ‘Infanta Elena’ University Hospital, Valdemoro, Madrid, Spain

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Aitor Ibarzábal-Gil Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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IJpma FFA et al. High diagnostic accuracy of white blood cell scintigraphy for fracture related infections: results of a large retrospective single-center study . Injury 2018 ; 49 : 1085 – 1090 . 10. Liodakis E Liodaki

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Karl Stoffel Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland

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Christoph Sommer Department of Surgery, Kantonsspital Graubuenden, Chur, Switzerland

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Mark Lee Department of Orthopaedic Surgery, UC Davis Medical Center, Sacramento, California, USA

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Tracy Y Zhu AO Innovation Translation Center, AO Foundation, Davos, Switzerland

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Karsten Schwieger AO Innovation Translation Center, AO Foundation, Davos, Switzerland

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Christopher Finkemeier Sutter Roseville Medical Center, Roseville, California, USA

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achieved full weight-bearing at a mean ( s.d. ) of 16 (5) weeks. NR No patients with peri- and interprosthetic fractures had complication; 1 out of 5 (20%) patients with reoperations developed a fracture-related infection. *Functional

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