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Hsiao-Yi Cheng Department of Primary Care Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Chun-Wei Liang School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan

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Yu-Hao Lee Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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Timporn Vitoonpong Department of Rehabilitation, King Chulalongkorn Memorial Hospital, Bankok, Thailand

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Chun-De Liao Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Master’s Program in Long-Term Care, College of Nursing, Taipei Medical University, Taipei, Taiwan

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Shih-Wei Huang Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

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, hyaluronic acids, platelet-rich plasma (PRP), platelet rich in growth factor (PRGF), botulinum toxin A, O 2 –O 3 , dextrose, and mesenchymal stem cell (MSC). Regarding exercise, most studies included resistance training programs to strengthen the quadriceps

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Valentina Viglione Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Angelo Boffa Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Davide Previtali Department of Surgery, EOC, Service of Orthopaedics and Traumatology, Lugano, Switzerland

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Francesca Vannini Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Cesare Faldini Clinica Ortopedica e Traumatologica 1 IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

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Giuseppe Filardo Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Department of Surgery, EOC, Service of Orthopaedics and Traumatology, Lugano, Switzerland
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland

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observed compared with the placebo group. Mansiz-Kaplan et al . ( 40 ) Injective Dextrose injection 33 3 months FFI, VAS-Activity, VAS-Rest Dextrose prolotherapy has efficacy up to 15 weeks and can be used as an alternative method in the

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Manuel Monteagudo Orthopaedic Foot and Ankle Unit, Hospital Universitario Quironsalud Madrid, Spain; Faculty of Medicine, UEM Madrid, Spain

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Pilar Martínez de Albornoz Orthopaedic Foot and Ankle Unit, Hospital Universitario Quironsalud Madrid, Spain; Faculty of Medicine, UEM Madrid, Spain

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Borja Gutierrez Orthopaedic Foot and Ankle Unit, Hospital Universitario Quironsalud Madrid, Spain; Faculty of Medicine, UEM Madrid, Spain

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José Tabuenca Orthopaedic Foot and Ankle Unit, Hospital Universitario Quironsalud Madrid, Spain; Faculty of Medicine, UEM Madrid, Spain

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Ignacio Álvarez Orthopaedic Foot and Ankle Unit, Hospital Universitario Quironsalud Madrid, Spain; Faculty of Medicine, UEM Madrid, Spain

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rupture together with limited results are in contrast with the wide use of cortisone injections for PF worldwide. Other injection therapies that have also been shown to have short-term and variable benefits include hyperosmolar dextrose, botulinum toxin A

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Hamid Rahmatullah Bin Abd Razak Department of Bioengineering, Imperial College London, London, UK
Sengkang General Hospital, Singapore
Joint first authors

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Daniel Chew Faculty of Medicine, Imperial College London, London, UK
Joint first authors

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Zepur Kazezian Department of Bioengineering, Imperial College London, London, UK

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Anthony M.J. Bull Department of Bioengineering, Imperial College London, London, UK

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vial of Anticoagulant Citrate Dextrose Solution Formula A (ACD-A). The first of the two devices is the nSTRIDE Cell Separator. It is a plastic tube containing a tuned-density buoy, which separates cellular and platelet components of whole blood to form

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Thomas Collins Trauma & Orthopaedics, Wythenshawe Hospital, Wythenshawe, UK

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Dinesh Alexander Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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Bilal Barkatali Trauma & Orthopaedics, Salford Royal Hospital, Salford, UK

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citrate dextrose-A (ACD-A) is the most commonly used in commercial kits. It maintains the optimal pH for platelets at 7.2 while the citrate binds to calcium preventing the coagulation cascade. They also recommend PRP be kept in small diameter tubes with

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