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Pablo Castillón Department of Trauma and Orthopaedic Surgery, Hospital, Universitari Mútua Terrassa, Terrassa, Barcelona, Spain
Universidad Autònoma de Barcelona (UAB), Bellaterra, Barcelona, Spain

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Josep Maria Muñoz Vives Department of Trauma and Orthopaedic Surgery, Hospital Althaia Manresa. Manresa, Barcelona, Spain
Department of Trauma and Orthopaedic Surgery, Hospital Nostra Senyora de Meritxell, Andorra

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Héctor José Aguado Department of Trauma and Orthopaedic Surgery, Hospital Clínico Universitario de Valladolid. Valladolid, Spain
Universidad de Valladolid, Valladolid, Spain

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Arantxa Capel Agundez Department of Trauma and Orthopaedic Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain

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Alina Ortega-Briones Department of Trauma and Orthopaedic Surgery, Hospital Clínico Universitario de Valladolid. Valladolid, Spain

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Jorge Hassan Núñez Department of Trauma and Orthopaedic Surgery, Hospital, Universitari Mútua Terrassa, Terrassa, Barcelona, Spain
Universidad Autònoma de Barcelona (UAB), Bellaterra, Barcelona, Spain

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the PISCO Investigators †
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the PISCO Investigators

, disuse osteopenia and fracture remodelling ( 5 ). Despite the proposed algorithms and classifications, the decision-making process is still unclear and there is lack of systematization and consensus. In addition, not only are these fractures treated by

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Elizabeth K Tissingh The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
King’s Global Health Partnerships, School of Life Course and Population Sciences, King’s College London, London, UK

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Leonard Marais Department of Orthopaedic Surgery, School of Clinical Medicine, University of KwaZulu-Natal, KwaZulu-Natal, South Africa

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Antonio Loro Comprehensive Rehabilitation Services for People with Disability in Uganda (CoRSU) Hospital, Kisubi, Uganda

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Deepa Bose University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Nilo T Paner Department of Orthopaedics, University of the Philippines, Philippine General Hospital Manila, The Phillipines

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Jamie Ferguson The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK
Department of Orthopaedics, University of the Philippines, Philippine General Hospital Manila, The Phillipines

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Mario Morgensten Centre for Musculoskeletal Infections, Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Basel, Switzerland

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Martin McNally The Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, UK

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complexity of managing FRI well, experts came together to discuss definitions and management principles. The International Consensus Meeting (ICM) Orthopaedic Trauma Work Group and the International Fracture Related Infection Consensus Group were born out of

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Philippe Beaufils Department of Orthopaedics and Traumatology, Centre Hospitalier de Versailles, 78150 Le Chesnay, France

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Roland Becker Department of Orthopaedics and Traumatology, Hospital Brandenburg, Medical School Theodor Fontane, Hochstrasse 26, 14770 Brandburg/Havel, Germany

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Sebastian Kopf Center for Musculoskeletal Surgery, Charité University Medicine, Berlin, Charitéplatz 1, 10117 Berlin, Germany

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Ollivier Matthieu Department of Orthopaedics and Traumatology, Centre Hospitalier de Versailles, 78150 Le Chesnay, and Aix Marseille Univ, CNRS, ISM, Inst Movement Sci, 13000 Marseille, France

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Nicolas Pujol Department of Orthopaedics and Traumatology, Centre Hospitalier de Versailles, 78150 Le Chesnay, France

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-economic constraints depend on healthcare systems. The objective of this review is to describe the current management of meniscus pathology based on current literature and on the ESSKA Meniscus Consensus Project, 8 which was presented in 2016. We will

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Thomas M Grupp Aesculap AG, Research & Development & Medical Scientific Affairs, Tuttlingen, Germany
Ludwig Maximilians University Munich, Department of Orthopaedic and Trauma Surgery, Musculoskeletal University Center Munich (MUM), Campus Grosshadern, Munich, Germany

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Sabine Rusch Aesculap AG, Research & Development & Medical Scientific Affairs, Tuttlingen, Germany

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Philippe Massin CMC Ambroise-Paré-Hartmann, Neuilly-sur-Seine, France

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Ashley Blom National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK
Translational Health Sciences, Bristol Medical School, Musculoskeletal Research Unit, University of Bristol, Southmead Hospital, Bristol, UK

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Eduardo Garcia-Rey Hôpital Universitario La Paz-Idi Paz, Madrid, Spain
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBN, Madrid, Spain

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Luca Cristofolini Department of Industrial Engineering, School of Engineering and Architecture, Alma Mater Studiorum - Università di Bologna, Bologna, Italy

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Dennis Janssen Radboud University Medical Center, Radboud Research Institute, Orthopaedic Research Lab, Nijmegen, the Netherlands

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Bernd Grimm Luxembourg Institute of Health, Human Motion, Orthopaedics, Sports Medicine & Digital Methods Group, Transversal Activities, Luxembourg

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Alexander Giurea Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria

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Marcus Jäger Department of Orthopaedics, Trauma & Reconstructive Surgery St. Marien Hospital Mülheim an der Ruhr & Chair of Orthopaedics and Trauma Surgery University of Duisburg–Essen, Essen, Germany

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Francesco Siccardi Medacta International SA, Research & Development & Medical Affairs, Castel San Pietro, Switzerland

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Søren Overgaard Copenhagen University Hospital, Department of Orthopaedic Surgery and Traumatology, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health & Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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of the 1 st EFORT European Consensus on ‘Medical and Scientific Research Requirements for the Clinical Introduction of Artificial Joint Arthroplasty Devices’ were foremost to focus on patient safety through performance requirements for medical

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Nuno Corte-Real Department of Orthopaedics, Hospital de Cascais Dr. José de Almeida, Portugal

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João Caetano Department of Orthopaedics, Hospital de Cascais Dr. José de Almeida, Portugal

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of the ankle. 2 Some of these patients will develop chronic ankle instability (CAI), making this situation an important and frequent condition. 1 Anatomy Consensus The lateral ankle ligament has three bundles: anterior talo

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Hagen Schmal Department of Orthopaedics and Traumatology, Odense University Hospital, Odense, Denmark.
Department of Orthopaedics and Traumatology, Freiburg University Hospital, Freiburg, Germany.

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Michael Brix Department of Orthopaedics and Traumatology, Odense University Hospital, Odense, Denmark.

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Mats Bue Department of Orthopaedic Surgery, Horsens Regional Hospital, Horsens, Denmark

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Anna Ekman Orthopaedic Department, Södersjukhuset, Stockholm, Sweden

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Nando Ferreira Division of Orthopaedics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Cape Town, South Africa

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Hans Gottlieb Department of Orthopaedic Surgery, Herlev Hospital, Herlev, Denmark

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Søren Kold Department of Orthopaedic Surgery, Aalborg University Hospital, Aalborg University, Aalborg, Denmark

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Andrew Taylor Department of Orthopaedic Surgery, Nottingham University Hospitals, UK

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Peter Toft Tengberg Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark

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Ilija Ban Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark

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Danish Orthopaedic Trauma Society Department of Orthopaedic Surgery, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark

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  • Nonunions are a relevant economic burden affecting about 1.9% of all fractures. Rather than specifying a certain time frame, a nonunion is better defined as a fracture that will not heal without further intervention.

  • Successful fracture healing depends on local biology, biomechanics and a variety of systemic factors. All components can principally be decisive and determine the classification of atrophic, oligotrophic or hypertrophic nonunions. Treatment prioritizes mechanics before biology.

  • The degree of motion between fracture parts is the key for healing and is described by strain theory. If the change of length at a given load is > 10%, fibrous tissue and not bone is formed. Therefore, simple fractures require absolute and complex fractures relative stability.

  • The main characteristics of a nonunion are pain while weight bearing, and persistent fracture lines on X-ray.

  • Treatment concepts such as ‘mechanobiology’ or the ‘diamond concept’ determine the applied osteosynthesis considering soft tissue, local biology and stability. Fine wire circular external fixation is considered the only form of true biologic fixation due to its ability to eliminate parasitic motions while maintaining load-dependent axial stiffness. Nailing provides intramedullary stability and biology via reaming. Plates are successful when complex fractures turn into simple nonunions demanding absolute stability. Despite available alternatives, autograft is the gold standard for providing osteoinductive and osteoconductive stimuli.

  • The infected nonunion remains a challenge. Bacteria, especially staphylococcus species, have developed mechanisms to survive such as biofilm formation, inactive forms and internalization. Therefore, radical debridement and specific antibiotics are necessary prior to reconstruction.

Cite this article: EFORT Open Rev 2020;5:46-57. DOI: 10.1302/2058-5241.5.190037

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Mattia Loppini Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona – Università degli Studi di Genova, Savona, Italy

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Francesco Manlio Gambaro Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy

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Rob G H H Nelissen Landelijke Registratie Orthopedische Implantaten (Dutch Arthroplasty Register), ’s Hertogenbosch, The Netherlands
Department of Orthopaedics, Leiden University Medical Center, Leiden, The Netherlands

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Guido Grappiolo IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Fondazione Livio Sciutto Onlus, Campus Savona – Università degli Studi di Genova, Savona, Italy

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Introduction Total hip arthroplasty (THA) is one of the most frequent and successful surgeries performed in the orthopedic field, nevertheless, a clear consensus on post-surgical management still lacks ( 1 ). The need to define a clear

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Maria Beatriz Quaresma Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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José Portela Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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Joaquim Soares do Brito Orthopaedics Department, University Hospital Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal

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behaviours, as well as the variety of joints involved, is difficult to establish an absolute standard for treatment. 8 The current consensus for treating a diffuse tenosynovial giant-cell tumour of the knee is surgical resection of the lesional tissue

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Abdus S. Burahee The Peripheral Nerve Injury Service, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Andrew D. Sanders The Peripheral Nerve Injury Service, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Dominic M. Power The Peripheral Nerve Injury Service, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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render the nerve susceptible to subluxation or neo-compression. There is no consensus on the management of cubital tunnel, and the aim of this article is to provide a guide to management based on our clinical experience of treating failed surgery

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Ioannis Ktistakis School of Medicine, University of Leeds, UK

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Vasileios Giannoudis School of Medicine, University of Leeds, UK

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Peter V. Giannoudis School of Medicine, University of Leeds; National Institute for Health Research, Leeds Biomedical Research Unit, Leeds, UK

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years ago, a non-consensus between units existed regarding the anticoagulation chemical VTE prophylaxis pre-operatively. But they advocated the start of Heparin (UFH or LWMH) 6-12 hours after surgery for 4 weeks, the early mobilization of the frail

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