Gerardo Fusco
Gerardo Fusco
Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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IRCCS Humanitas Research Hospital, Milan, Italy
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Francesco M. Gambaro
Francesco M. Gambaro
Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
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IRCCS Humanitas Research Hospital, Milan, Italy
These authors contributed equally to the article and should both be considered first authors
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Berardo Di Matteo
Berardo Di Matteo
Humanitas University, Department of Biomedical Sciences, Milan, Italy
First Moscow State Medical University – Sechenov University, Moscow, Russia
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First Moscow State Medical University – Sechenov University, Moscow, Russia
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Elizaveta Kon
Elizaveta Kon
Humanitas University, Department of Biomedical Sciences, Milan, Italy
IRCCS Humanitas Research Hospital, Milan, Italy
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IRCCS Humanitas Research Hospital, Milan, Italy
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digestion with collagenase and trypsin, but, following safety and regulatory concerns, minimally manipulative methods were developed, 45 exploiting mechanical forces such as centrifugation or microfragmentation in order to obtain a readily injectable
Alessandro Bensa
Alessandro Bensa
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Alessandro Sangiorgio
Alessandro Sangiorgio
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Angelo Boffa
Angelo Boffa
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Manuela Salerno
Manuela Salerno
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Giacomo Moraca
Giacomo Moraca
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Giuseppe Filardo
Giuseppe Filardo
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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deleterious effects of different CS on cartilage tissue, inducing apoptosis in human chondrocytes and aggravating the condition of the cartilage matrix already suffering from the OA environment, upregulating aggrecanases, collagenases, and metalloproteinases
