Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania
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Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania
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Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania
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Department of Emergency Medicine, Emergency University Hospital, Bucharest, Romania
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Department of Orthopaedics and Traumatology, Emergency University Hospital Bucharest, Romania
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intervention. These interventions aim to alleviate symptoms, especially since RCC bone metastases tend to be osteolytic ( 11 ). Even with advancements like T cell checkpoint and tyrosine kinase inhibitors, managing bone metastasis remains challenging ( 12 , 13
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Introduction Due to constantly improving treatments that prolong the palliative phase of many different cancers, the incidence of bone metastases is increasing. 1 Nowadays, over two-thirds of patients receiving palliative care will
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diagnostic problem or if ablative surgery is planned. Evaluating laboratory findings, the patient’s condition and the local stage of the tumour, we can decide whether to perform radical or palliative surgery. In cases with multiple bone metastases, surgery
Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania
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Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania
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Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania
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Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania
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Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania
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Orthopedics and Traumatology Department, University Emergency Hospital Bucharest, Bucharest, Romania
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Introduction The most common malignant bone tumors are bone metastases, which are caused by visceral tumors and primary hematopoietic neoformations. With the evolution of oncological treatments, which have led to increased survival of cancer
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Tumour endoprostheses have facilitated limb-salvage procedures in primary bone and soft tissue sarcomas, and are increasingly being used in symptomatic metastases of the long bones.
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The objective of the present review was to analyse articles published over the last three years on tumour endoprostheses and to summarize current knowledge on this topic. The NCBI PubMed webpage was used to identify original articles published between January 2015 and April 2018 in journals with an impact factor in the top 25.9% of the respective category (orthopaedics, multidisciplinary sciences).
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The following search-terms were used: tumour endoprosthesis, advances tumour endoprosthesis, tumour megaprosthesis, prosthetic reconstruction AND tumour. We identified 347 original articles, of which 53 complied with the abovementioned criteria.
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Articles were categorized into (1) tumour endoprostheses in the shoulder girdle, (2) tumour endoprostheses in the proximal femur, (3) tumour endoprostheses of the knee region, (4) tumour endoprostheses in the pelvis, (5) (expandable) prostheses in children and (6) long-term results of tumour endoprostheses.
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The topics of interest covered by the selected studies largely matched with the main research questions stated at a consensus meeting, with survival outcome of orthopaedic implants being the most commonly raised research question.
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As many studies reported on the risk of deep infections, research in the future should also focus on potential preventive methods in endoprosthetic tumour reconstruction.
Cite this article: EFORT Open Rev 2019;4:445-459. DOI: 10.1302/2058-5241.4.180081
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Bone metastases arise most commonly in patients suffering from breast, prostate, kidney or lung cancer. 1 Two-thirds of all patients dying of cancer reportedly develop bone metastases; 2 however, a modern, image-based study would
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metastasize to the bone. Still, the most frequent histotypes are breast cancer, pulmonary cancer (non-small cell lung cancer), thyroid, and prostatic cancer ( 1 ). These four histotypes account for 80% of all bone metastases ( 1 ). There are various
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regarding anti-angiogenesis. It is approved and successfully used in the treatment of hypervascularised bone metastases of renal cell carcinoma. Wang et al. ( 60 ) presented a case report in 2019 of an effective combined treatment of denosumab and
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, a fracture was reported following daily ibandronate prescribed for bone metastases in breast cancer. 22 Since the application of antiresorptive drugs in these patients is also employed in long-term settings, this phenomenon is expected to become
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
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Department of Pediatrics, Kyung Hee University College of Medicine, Seoul, Republic of Korea
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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experiments; v) study subjects with non-osteoporotic fractures; or non-vertebral fractures; vi) study subjects with secondary osteoporosis, such as (GIOP, malignant tumor associated bone diseases, bone metastases); vii) study subjects participants with