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Fabian Krause Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Helen Anwander Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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stimulation (regeneration) In 1959, Pridie ( 22 ) introduced bone marrow stimulation (BMS; i.e. microfracture, retrograde drilling) of OLT. Today, BMS is the most common first-line technique of operative treatment for OLT, even without proven superiority

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Markus Walther Schön Klinik München Harlaching – FIFA Medical Centre of Excellence, Harlachinger Straße, Munich, Germany
Ludwig Maximilian University Munich, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Zentrum München (MUM), Marchionostraße, Munich, Germany
Justus Maximilian University Wuerzburg, König-Ludwig-Haus, Brettreichstraße, Würzburg, Germany
Paracelsus Medizinische Privatuniversität, Strubergasse, Salzburg, Austria
Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany

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Oliver Gottschalk Schön Klinik München Harlaching – FIFA Medical Centre of Excellence, Harlachinger Straße, Munich, Germany
Ludwig Maximilian University Munich, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Zentrum München (MUM), Marchionostraße, Munich, Germany
Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany

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Matthias Aurich Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany
Martin-Luther-University Halle-Wittenberg, Universitätsklinikum Halle (Saale), DOUW - Abteilung für Unfall- und Wiederherstellungschirurgie, Ernst-Grube-Straße, Halle, Germany
BG-Klinikum Bergmannstrost Halle, Halle, Saale, Germany

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marrow stimulation (scientifically neutral term, includes protected trademarks like MFx®, Microfracture®, Nanofracture®, Microdrilling®) M-BMS Matrix-associated bone marrow stimulation (scientifically neutral term, includes protected trademarks

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Alfonso Vaquero-Picado Department of Orthopaedic Surgery, ‘La Paz’ University Hospital, Spain

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, ‘La Paz’ University Hospital, Spain

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Supplemental bone marrow stimulation These techniques are designed to recreate the environment of an ACL reconstruction to enhance healing of isolated meniscal tears. While in ACL reconstruction drilling tunnels releases growth factors, blood and platelets

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Helen Anwander Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Philipp Vetter Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Christophe Kurze Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Chui J Farn Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Department of Orthopedic Surgery, National Taiwan University Hospital, Taiwan, Republic of China

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Fabian G Krause Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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treatment group. BMS, bone marrow stimulation; AMIC, autologous matrix-induced chondrogenesis; ACI, autologous chondrocyte implantation; MACI, matrix-induced ACI; OATS, osteochondral autologous transplantation surgery; + add. therapies, with additional

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Joseph J Ruzbarsky Steadman Philippon Research Institute, Vail, Colorado, USA
Steadman Clinic and United States Coalition for the Prevention of Illness and Injury in Sport, Vail, Colorado, USA

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Rui W Soares Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio, USA

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Spencer M Comfort Steadman Philippon Research Institute, Vail, Colorado, USA

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Justin W Arner Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

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Marc J Philippon Steadman Philippon Research Institute, Vail, Colorado, USA
Steadman Clinic and United States Coalition for the Prevention of Illness and Injury in Sport, Vail, Colorado, USA

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intake of losartan) provided superior repair via decreasing fibrocartilage formation and resulting in hyaline-like cartilage as compared with outcomes from bone marrow stimulation only NA   Kobayashi et al. ( 13 ) In a murine model of muscle

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Mukai Chimutengwende-Gordon Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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James Donaldson Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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George Bentley Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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been used. This review discusses current treatment options with a focus on chronic osteochondral defects of the knee. Bone marrow stimulation techniques Bone marrow stimulation procedures are commonly used to treat osteochondral lesions and are

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Oliver Marin-Peña Orthopedic Surgery and Traumatology, University Hospital Infanta Leonor, Madrid, Spain

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Marc Tey-Pons Hospital del Mar, Barcelona, Spain

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Luis Perez-Carro Clinica Mompia Santander, Spain

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Hatem G. Said Assiut University Hospital, Assiut, Egypt

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Pablo Sierra Madrid. University Hospital Torrejon, Madrid, Spain

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Pedro Dantas Hospital CUF Descobertas, Lisboa, Portugal

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Richard N. Villar Spire Cambridge Lea Hospital, Cambridge, UK

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marrow stimulation techniques like BST Cargel, 24 AMIC techniques 25 or with chondrocyte cultures. 26 These are promising techniques but there is still a lack of long-term results ( Fig. 2 ). Fig. 2 Arthroscopic view from the

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Ahmed Mabrouk Mid Yorkshire Teaching Hospitals, Yorkshire, United Kingdom
Institut du mouvement et de l’appareil locomoteur, Marseille, France

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Jae-Sung An Institut du mouvement et de l’appareil locomoteur, Marseille, France

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Kristian Kley Orthoprofis Hannover, Hannover, Germany

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Komal Tapasvi The Orthopaedic Speciality Clinic, Pune, India

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Sachin Tapasvi The Orthopaedic Speciality Clinic, Pune, India

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Matthieu Ollivier Institut du mouvement et de l’appareil locomoteur, Marseille, France

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to achieve the desired outcomes with no complications. Kumagai et al. 2018 ( 31 ) compared OWHTO + OATs vs OWHTO + bone marrow stimulation (BMS) in patients with spontaneous osteonecrosis of the knee (SONK) of the MFC. The mean femorotibial angle

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Tahir Ögüt Cerrahpasa Medical School, Departmant of Orthopaedics and Traumatology, University of Istanbul, Turkey
Nisantasi Ortopedi Merkezi, Hakkı Yeten Cad., Unimed Center, No:19, 34365 Fulya, Istanbul, Turkey

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N. Selcuk Yontar Cerrahpasa Medical School, Departmant of Orthopaedics and Traumatology, University of Istanbul, Turkey
Nisantasi Ortopedi Merkezi, Hakkı Yeten Cad., Unimed Center, No:19, 34365 Fulya, Istanbul, Turkey

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, Kanazawa K , Takeyama A , et al. . Arthroscopic bone marrow stimulation techniques for osteochondral lesions of the talus: prognostic factors for small lesions . Am J Sports Med 2013 ; 41 : 528 - 534 . 29 Choi WJ

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Silvia Valisena Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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Benjamin Azogui Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Rémy S Nizard Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Philippe M Tscholl Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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Etienne Cavaignac Department of Orthopaedics, Hôpital Pierre Paul Riquet, CHU Toulouse, Toulouse, France

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Pierre-Alban Bouché Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Didier Hannouche Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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performance ( 2 , 4 , 5 ). In the last century, the treatment of symptomatic patients has remarkably evolved. Repair techniques such as bone marrow stimulation, debridement, abrasion, and subchondral drilling have been gradually replaced by microfractures

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