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Silvia Valisena Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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Benjamin Azogui Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Rémy S Nizard Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Philippe M Tscholl Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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Etienne Cavaignac Department of Orthopaedics, Hôpital Pierre Paul Riquet, CHU Toulouse, Toulouse, France

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Pierre-Alban Bouché Department of Orthopaedics, Hôpital Lariboisière, Paris, France

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Didier Hannouche Department of Orthopaedics, University Hospitals of Geneva, Genève, Switzerland

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), minced cartilage procedures for allografts and autografts replacement ( 10 , 11 ), and multiple generations of autologous chondrocyte implantation (ACI). The latter has evolved from the injection of cultured autologous chondrocytes below a periosteum

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Mukai Chimutengwende-Gordon Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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James Donaldson Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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George Bentley Joint Reconstruction Unit, Royal National Orthopaedic Hospital Trust, Stanmore, UK

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to autologous chondrocyte implantation (ACI) except for very small lesions of less than 2 cm 2 . 25 Osteochondral allograft transplantation Fresh osteochondral allograft (OCA) transplantation is an alternative to OATS and may be useful in

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Markus Walther Schön Klinik München Harlaching – FIFA Medical Centre of Excellence, Harlachinger Straße, Munich, Germany
Ludwig Maximilian University Munich, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Zentrum München (MUM), Marchionostraße, Munich, Germany
Justus Maximilian University Wuerzburg, König-Ludwig-Haus, Brettreichstraße, Würzburg, Germany
Paracelsus Medizinische Privatuniversität, Strubergasse, Salzburg, Austria
Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany

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Oliver Gottschalk Schön Klinik München Harlaching – FIFA Medical Centre of Excellence, Harlachinger Straße, Munich, Germany
Ludwig Maximilian University Munich, Klinik für Orthopädie und Unfallchirurgie, Muskuloskelettales Zentrum München (MUM), Marchionostraße, Munich, Germany
Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany

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Matthias Aurich Working Group Clinical Tissue Regeneration of the German Society of Orthopaedics and Traumatology (DGOU), Berlin, Germany
Martin-Luther-University Halle-Wittenberg, Universitätsklinikum Halle (Saale), DOUW - Abteilung für Unfall- und Wiederherstellungschirurgie, Ernst-Grube-Straße, Halle, Germany
BG-Klinikum Bergmannstrost Halle, Halle, Saale, Germany

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. AOFAS American Orthopedic Foot and Ankle Society ACI Autologous chondrocyte implantation (scientifically neutral term, includes protected trademarks like MACI®) DGOU German Society of Orthopedic and Trauma Surgeons BMS Bone

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Helen Anwander Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Philipp Vetter Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Christophe Kurze Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Chui J Farn Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
Department of Orthopedic Surgery, National Taiwan University Hospital, Taiwan, Republic of China

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Fabian G Krause Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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. The sealing of the defect with a collagen matrix after BMS describes the technique of autologous matrix-induced chondrogenesis (AMIC) ( 6 ). Autologous chondrocyte implantation (ACI) ( 7 ) is a two-step procedure. Initially, healthy cartilage is

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Maurilio Marcacci Rizzoli Orthopaedic Institute - II Clinic- Biomechanics Laboratory, Bologna, Italy

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Luca Andriolo Rizzoli Orthopaedic Institute - II Clinic- Biomechanics Laboratory, Bologna, Italy

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Elizaveta Kon Rizzoli Orthopaedic Institute - II Clinic- Biomechanics Laboratory, Bologna, Italy

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Nogah Shabshin Carmel Medical Center, Department of Radiology, Haifa, Israel

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Giuseppe Filardo Rizzoli Orthopaedic Institute - II Clinic- Biomechanics Laboratory, Bologna, Italy

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cartilage treatments. 15 Perifocal bone marrow oedema-like signals are a frequent finding after both chondral and osteochondral surgical procedures (e.g. microfracture, autologous chondrocyte implantation, osteochondral autograft or allograft

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Fabian Krause Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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Helen Anwander Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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disability subscales and high patient satisfaction after 24 months and 10-year follow-up ( 35 ). Cartilage implantation (regeneration) Autologous chondrocyte implantation (ACI) is a two-step procedure ( 36 ). Healthy chondrocytes are sampled from a

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Ahmed Mabrouk Mid Yorkshire Teaching Hospitals, Yorkshire, United Kingdom
Institut du mouvement et de l’appareil locomoteur, Marseille, France

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Jae-Sung An Institut du mouvement et de l’appareil locomoteur, Marseille, France

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Kristian Kley Orthoprofis Hannover, Hannover, Germany

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Komal Tapasvi The Orthopaedic Speciality Clinic, Pune, India

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Sachin Tapasvi The Orthopaedic Speciality Clinic, Pune, India

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Matthieu Ollivier Institut du mouvement et de l’appareil locomoteur, Marseille, France

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autologous chondrocyte implantation (ACI) in cartilage defects of the medial femoral condyle with or without high tibial osteotomy in patients with varus deformity of less than 5° . Archives of Orthopaedic and Trauma Surgery 2013 133 43 – 49 . ( https

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Javier Masquijo Department of Pediatric Orthopaedics, Sanatorio Allende, Córdoba, Argentina

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Alpesh Kothari Department of Paediatric Orthopaedics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

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marrow stimulation (microfractures), OATS, fresh osteochondral allograft, autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI). This is a very unusual scenario for the paediatric–adolescent population and

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Sebastian Kopf Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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Manuel-Paul Sava Orthopedics and Traumatology 2nd Department, Colentina Clinical Hospital, Bucharest, Romania

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Christian Stärke Department of Orthopaedic Surgery, Otto-von-Guericke University Magdeburg, Germany

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Roland Becker Center of Orthopaedics and Traumatology, Brandenburg Medical School Theodor Fontane, Germany

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evidence-based systematic analysis . Am J Sports Med 2009 ; 37 : 2053 – 2063 . 70. Minas T Gomoll AH Rosenberger R Royce RO Bryant T . Increased failure rate of autologous chondrocyte implantation

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Tobias Winkler Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Sven Geissler Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Tazio Maleitzke Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

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Carsten Perka Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany

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Georg N Duda Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health Center for Regenerative Therapies, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

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Alexander Hildebrandt Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany

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that supports physiological bone formation via endochondral ossification by providing an organized pore network ( 62 ). Autologous chondrocyte implantation (ACI) also used as matrix-associated ACI (MACI), a cell-based approach (in the case of MACI

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