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turnover, long-term use is associated with an altered bone structure and biomechanics. 2 As a direct consequence, the occurrence of atypical femoral fractures has been described and linked to a negative side-effect of antiresorptive therapy. 3
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) of denosumab treatment with longer follow-up. The authors found, however, that the ratio of osteonecrosis of the jaw increased with increasing denosumab exposure and all of the rare atypical femoral fractures in their patients occurred following long
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University of Leeds, Leeds, UK
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2012 ; 23 : 1823 – 1834 . 30. MacKenzie SA Ng RT Snowden G Powell-Bowns MFR Duckworth AD Scott CEH . Periprosthetic atypical femoral fractures exist and are associated with duration of
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran
Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
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& Lee SH. Effect of Teriparatide on Healing of Atypical Femoral Fractures: A Systemic Review . Journal of Bone Metabolism 2015 22 183 – 189 . ( https://doi.org/10.11005/jbm.2015.22.4.183 ) 32 Kanakaris NK West RM & Giannoudis PV