Humanitas Clinical and Research Center, Milan, Italy
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Humanitas Clinical and Research Center, Milan, Italy
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Humanitas Clinical and Research Center, Milan, Italy
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available 15 , 29 , 30 including synovial leukocyte esterase (LE), 19 , 31 , 32 synovial alpha defensin (AD), 16 , 33 and synovial C-reactive protein (CRP). 34 , 35 Deirmengian et al 15 have identified and studied the diagnostic
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many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses. 34 Defensins in mammals are classified into alpha, beta and theta categories, based on their size and pattern of disulfide bonding. Alpha-defensins are particularly found
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causative organisms. LE is a cheap screening tool which, due to its specificity, has been shown to be accurate at excluding cases of infection in cases of PJI. Alpha-defensin assay There has been increasing interest in the use of the alpha-defensin
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days is necessary to detect low-virulent and difficult-to-detect pathogens, such as Cutibacterium species. Alpha defensin Alpha defensin is an antimicrobial peptide released by activated neutrophils as a response to bacterial infection that
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Department of Orthopaedics and Trauma Surgery, Medical University of Vienna, Austria
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diagnosis of PJI. Promising results were reported for alpha defensin, an antimicrobial peptide released by neutrophils in response to pathogens. The quantitative alpha-defensin test (ELISA) showed sensitivities ranging from 75 to 100% and specificities from
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be useful to detect periprosthetic hip infection . Clin Orthop Relat Res 2010 ; 468 ( 12 ): 3263 - 3267 . 29. Bonanzinga T Zahar A Dütsch M . How reliable is the alpha-defensin immunoassay test for diagnosing
Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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Division of Orthopaedics and Trauma Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
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acnes). 50 Similarly, due to the low virulence of most Cutibacteria, there is no role for CRP as diagnostic criterion 50 as well as alpha defensin. 51 CRP is, however, important for general evaluation of the patient. Pre-revision tissue culture with
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Shoulder Elbow Surg 2019 ; 28 : 1 – 8 . 61. Goswami K Parvizi J Maxwell Courtney P . Current recommendations for the diagnosis of acute and chronic PJI for hip and knee-cell counts, alpha-defensin, leukocyte esterase
