Laboratory of Tribology and System Dynamics, Ecole Centrale Lyon, France.
Laboratory of Bioengineering and Bioimagery for Bone and Articulation, Paris-Diderot University, France.
Search for other papers by Jean-Charles Aurégan in
Google Scholar
PubMed
Search for other papers by Catherine Bosser in
Google Scholar
PubMed
Search for other papers by Morad Bensidhoum in
Google Scholar
PubMed
Search for other papers by Thierry Bégué in
Google Scholar
PubMed
Search for other papers by Thierry Hoc in
Google Scholar
PubMed
and bone tissues with age. Hence, measurement of certain skin parameters could be performed in order to estimate bone parameters. The general process of ageing could explain the origins of the correlation between the alterations of skin and bone
Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK
Search for other papers by Marilena Giannoudi in
Google Scholar
PubMed
NIHR Leeds Biomedical Research Centre, Chapel Allerton Hospital, Leeds, UK
Search for other papers by Peter V Giannoudis in
Google Scholar
PubMed
inhibitors have been associated with an increased risk of adverse events in the elderly population when compared to their younger counterparts. This is due to changes in the pharmacokinetics and pharmacodynamics within the ageing population, as well as the
Search for other papers by Yangqi Xu in
Google Scholar
PubMed
Search for other papers by Tony B Huang in
Google Scholar
PubMed
Department of Orthopaedic Surgery, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia
Queensland University of Technology (QUT), Brisbane, Queensland, Australia
Search for other papers by Michael A Schuetz in
Google Scholar
PubMed
Department of Orthopaedics, St. Vincent’s Hospital, Fitzroy, Victoria, Australia
Search for other papers by Peter F M Choong in
Google Scholar
PubMed
Search for other papers by the ICARAUS group in
Google Scholar
PubMed
$46 000 in developed countries (United States and Australia) ( 7 , 8 ). The incidence of PJI is expected to increase substantially over the next few decades because of the ageing populations and changing demographic characteristics, including rates
Search for other papers by The International Orthopaedic Diversity Alliance in
Google Scholar
PubMed
, the medical profession will be affected by reducing workforce numbers due to ageing and feminization. 30 The number of orthopaedic surgeons has risen sharply in 30 years, increasing from 1.44:100,000 inhabitants in 1981 to 4.3 in 2013. Between
Search for other papers by Shankar Aissvarya in
Google Scholar
PubMed
Genetics & Regenerative Medicine Research Group, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Malaysian Research Institute on Ageing (MyAgeing), Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Search for other papers by King-Hwa Ling in
Google Scholar
PubMed
School of Medicine, Faculty of Medicine and Health Sciences, Taylor's University, Selangor, Malaysia
Search for other papers by Manohar Arumugam in
Google Scholar
PubMed
Genetics & Regenerative Medicine Research Group, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Malaysian Research Institute on Ageing (MyAgeing), Universiti Putra Malaysia, Serdang, Selangor, Malaysia
Search for other papers by Karuppiah Thilakavathy in
Google Scholar
PubMed
-
Dupuytren’s contracture (DC) is a fibroproliferative disorder of the palmar fascia characterised by the digits’ flexion contractures and is associated with abnormal build-up of type III collagen. The prevalence of the disease is reported to be highest among Northern European descendants. However, the disease is widespread globally with varying prevalence.
-
DC is a multifactorial disease, having both genetic and environmental factors contributing to the causality of the disease.
-
Over the years, various studies have been conducted to understand the molecular mechanism and genetic aspects of DC but there is a lack of reports on the variants found in the exonic regions. Most reports are backdated making it necessary to re-evaluate the variants to further understand the genetic aetiology of DC.
-
In this review, we first highlight the genetic aspects and previous genetic studies on DC. The report is followed by a discussion on the molecular pathways suggested to be associated with DC and a summary of the genetic variants in the exonic regions found in DC and their connections with the molecular pathways.
-
A total of nine variants were reported originating from six genes comprising three pathways. Most variants reported are involved in the Wnt signalling pathway. Moreover, all variants identified are in European/Caucasian subjects and the variants found in the exonic regions are missense variants.
-
A comparison of these findings with variants from populations of other regions can be conducted to identify the variants with the most occurrence to act as biomarkers or therapeutic targets for DC.
Humanitas Clinical and Research Center, Milan, Italy
Search for other papers by Tommaso Bonanzinga in
Google Scholar
PubMed
Search for other papers by Matteo Carlo Ferrari in
Google Scholar
PubMed
Search for other papers by Piergiuseppe Tanzi in
Google Scholar
PubMed
Humanitas Clinical and Research Center, Milan, Italy
Search for other papers by Filippo Vandenbulcke in
Google Scholar
PubMed
Search for other papers by Akos Zahar in
Google Scholar
PubMed
Humanitas Clinical and Research Center, Milan, Italy
Search for other papers by Maurilio Marcacci in
Google Scholar
PubMed
is not standardized worldwide and the outcome is frequently unsatisfactory because of the increasing number of highly virulent and antibiotic-resistant bacteria, and due to an ageing patient population presenting with many comorbidities. PJI
Search for other papers by Dominic Davenport in
Google Scholar
PubMed
Search for other papers by Venu Kavarthapu in
Google Scholar
PubMed
suggest that around 8.5 million people in the UK are affected by joint pain secondary to arthritis, and a rise in the ageing population has resulted in an increase in THA operations of around 4% per year over the last six years. 1 Multiple studies
Search for other papers by Rafik Yassa in
Google Scholar
PubMed
Search for other papers by Mahdi Yacine Khalfaoui in
Google Scholar
PubMed
Search for other papers by Ihab Hujazi in
Google Scholar
PubMed
Search for other papers by Hannah Sevenoaks in
Google Scholar
PubMed
Search for other papers by Paul Dunkow in
Google Scholar
PubMed
Introduction Hip fractures are common orthopaedic injuries with an estimated 60 000 to 75 000 cases each year in the United Kingdom, at an estimated annual cost of £2 billion to the NHS. This cost is growing due to the increase in the ageing
Search for other papers by Cheuk Yin Li in
Google Scholar
PubMed
Search for other papers by Kenneth Jordan Ng Cheong Chung in
Google Scholar
PubMed
Search for other papers by Omar M. E. Ali in
Google Scholar
PubMed
Search for other papers by Nicholas D. H. Chung in
Google Scholar
PubMed
Search for other papers by Cheuk Heng Li in
Google Scholar
PubMed
increasingly ageing population. 3 The most common indication for TKR is osteoarthritis (OA). 1 In 2018, 96.2% of primary knee replacements were conducted solely due to osteoarthritis. 2 TKR helps to improve quality of life and function in end
Search for other papers by Jennette Higgs in
Google Scholar
PubMed
Search for other papers by Emma Derbyshire in
Google Scholar
PubMed
Search for other papers by Kathryn Styles in
Google Scholar
PubMed
-
Osteoporosis is a prevalent and debilitating condition with no signs of subsiding. Rising numbers of people consuming nutrient-poor diets coupled with ageing populations and sedentary lifestyles appear to be the main drivers behind this.
-
While the nutrients calcium and vitamin D have received most attention, there is growing evidence that wholefoods and other micronutrients have roles to play in primary and potentially secondary osteoporosis prevention.
-
Until recently, calcium and vitamin D were regarded as the main nutrients essential to bone health but now there are emerging roles for iron, copper and selenium, among others.
-
Fruit and vegetables are still not being eaten in adequate amounts and yet contain micronutrients and phytochemicals useful for bone remodelling (bone formation and resorption) and are essential for reducing inflammation and oxidative stress.
-
There is emerging evidence that dried fruits, such as prunes, provide significant amounts of vitamin K, manganese, boron, copper and potassium which could help to support bone health.
-
Just 50 g of prunes daily have been found to reduce bone resorption after six months when eaten by osteopaenic, postmenopausal women.
-
Dairy foods have an important role in bone health. Carbonated drinks should not replace milk in the diet.
-
A balanced diet containing food groups and nutrients needed for bone health across the whole lifecycle may help to prevent osteoporosis.
-
Greater efforts are needed to employ preventative strategies which involve dietary and physical activity modifications, if the current situation is to improve.
Cite this article: EFORT Open Rev 2017;2:300-308. DOI: 10.1302/2058-5241.2.160079
