Search for other papers by Stephanie Marrannes in
Google Scholar
PubMed
Search for other papers by Klaas Victor in
Google Scholar
PubMed
Search for other papers by Nele Arnout in
Google Scholar
PubMed
Search for other papers by Tine De Backer in
Google Scholar
PubMed
Search for other papers by Jan Victor in
Google Scholar
PubMed
Search for other papers by Thomas Tampere in
Google Scholar
PubMed
Introduction Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), is a well-known complication following orthopaedic surgery. In the absence of thromboprophylaxis, incidences up to 40% have been
Search for other papers by Dimitrios A. Flevas in
Google Scholar
PubMed
Search for other papers by Panayiotis D. Megaloikonomos in
Google Scholar
PubMed
Search for other papers by Leonidas Dimopoulos in
Google Scholar
PubMed
Search for other papers by Evanthia Mitsiokapa in
Google Scholar
PubMed
Search for other papers by Panayiotis Koulouvaris in
Google Scholar
PubMed
Search for other papers by Andreas F. Mavrogenis in
Google Scholar
PubMed
Introduction Venous thromboembolism (VTE) is a common complication during and after hospitalization for medical and surgical patients, including orthopaedic patients. More than half of all hospitalized patients are at risk for VTE, with a
Faculty of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
Search for other papers by Leonard Christianto Singjie in
Google Scholar
PubMed
Search for other papers by Reynaldo Halomoan in
Google Scholar
PubMed
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Search for other papers by Ifran Saleh in
Google Scholar
PubMed
Search for other papers by Endrotomo Sumargono in
Google Scholar
PubMed
Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Search for other papers by Erica Kholinne in
Google Scholar
PubMed
Introduction Patients undergoing major orthopedic surgeries, such as total hip replacement (THR), total knee replacement (TKR), and trauma surgery (hip/femur fracture), are at an elevated risk of venous thromboembolism (VTE). Deep vein
Search for other papers by Ioannis Ktistakis in
Google Scholar
PubMed
Search for other papers by Vasileios Giannoudis in
Google Scholar
PubMed
Search for other papers by Peter V. Giannoudis in
Google Scholar
PubMed
tables. Results For part A, the following guidelines were reviewed (see Table 1 ). 1 , 3 - 6 NICE guidelines (CG92) recommend combined VTE prophylaxis with mechanical and pharmacological methods for patients undergoing hip fracture
Search for other papers by Stefan Lazic in
Google Scholar
PubMed
Search for other papers by Oliver Boughton in
Google Scholar
PubMed
Search for other papers by Catherine F. Kellett in
Google Scholar
PubMed
Search for other papers by Deiary F. Kader in
Google Scholar
PubMed
Search for other papers by Loïc Villet in
Google Scholar
PubMed
MSK Lab, Imperial College London, UK
Search for other papers by Charles Rivière in
Google Scholar
PubMed
increased risk of surgical site infection. 45 Venous thromboembolism (VTE) prophylaxis Preventing post-operative VTE without significantly increasing the risk of bleeding is best accomplished with a multimodal patient-specific approach using non
Search for other papers by Haroon Majeed in
Google Scholar
PubMed
,681,447 Bladder injury 31 9,771,348 Rupture of a structure 18 975,811 Compartment syndrome 48 12,239,999 VTE 118 10,648,277 Tendon injury 132 10,706,687 Psychiatric issues 40 3,386,709 Pressure
Department of Pharmaceutical, Lanzhou University Second Hospital, Lanzhou, Gansu province, P.R. China
Search for other papers by Xiangji Dang in
Google Scholar
PubMed
Search for other papers by Mei Liu in
Google Scholar
PubMed
Search for other papers by Qiang Yang in
Google Scholar
PubMed
Search for other papers by Jin Jiang in
Google Scholar
PubMed
Search for other papers by Yan Liu in
Google Scholar
PubMed
Search for other papers by Hui Sun in
Google Scholar
PubMed
Search for other papers by Jinhui Tian in
Google Scholar
PubMed
venous thromboembolism (VTE), myocardial infarction (MI), cerebrovascular accident, and transient ischemic attack present a unique challenge due to their heightened susceptibility to thromboembolic events. These factors intricately contribute to the
Department of Orthopaedic Surgery, Vejle Hospital, Vejle, Denmark
Search for other papers by Claus Varnum in
Google Scholar
PubMed
Search for other papers by Alma Bečić Pedersen in
Google Scholar
PubMed
Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Search for other papers by Ola Rolfson in
Google Scholar
PubMed
Lund University, Skåne University Hospital, Department of Orthopedics, Malmö, Sweden
Search for other papers by Cecilia Rogmark in
Google Scholar
PubMed
Department of Clinical Medicine, University of Bergen, Bergen, Norway
Search for other papers by Ove Furnes in
Google Scholar
PubMed
Department of Clinical Medicine, University of Bergen, Bergen, Norway
Search for other papers by Geir Hallan in
Google Scholar
PubMed
Department of Orthopaedics and Traumatology, Turku University Hospital, Turku, Finland
Search for other papers by Keijo Mäkelä in
Google Scholar
PubMed
Department of Surgery, Epworth HealthCare, University of Melbourne, Melbourne, Australia
Search for other papers by Richard de Steiger in
Google Scholar
PubMed
Centre for Hip Surgery, Wrightington Hospital, Wrightington, Wigan and Leigh NHS Trust, Lancashire, United Kingdom
Search for other papers by Martyn Porter in
Google Scholar
PubMed
Orthopaedic Research Unit, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Odense, Denmark
Search for other papers by Søren Overgaard in
Google Scholar
PubMed
thromboembolism (VTE) and blood transfusion have also been thoroughly investigated. Pharmacological thromboprophylaxis is a standard and well-accepted peri-operative treatment. Despite treatment, risk of symptomatic VTE has been reported to be up to 6% within 90
Search for other papers by Richard Peter Almeida in
Google Scholar
PubMed
Search for other papers by Lipalo Mokete in
Google Scholar
PubMed
Search for other papers by Nkhodiseni Sikhauli in
Google Scholar
PubMed
Search for other papers by Allan Roy Sekeitto in
Google Scholar
PubMed
Search for other papers by Jurek Pietrzak in
Google Scholar
PubMed
, enoxaparin (low molecular weight heparin), fondaparinux, rivaroxaban and aspirin to mitigate the risk of venous thromboembolic events (VTE). 4 , 31 Each of the agents have different mechanisms of actions, dosages and routes of administration, with negative
Search for other papers by Ioannis V. Papachristos in
Google Scholar
PubMed
NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK
Search for other papers by Peter V. Giannoudis in
Google Scholar
PubMed
(Xarelto), apixaban (Eliquis) and edoxaban (Lixiana) and was quite recently introduced in 2013 for prevention of thrombo-embolism after elective total hip or knee replacement. Their indications were extended to treatment of venous thrombo-embolism (VTE) and