Di Zhao
Di Zhao
The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Ling-feng Zeng
Ling-feng Zeng
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Gui-hong Liang
Gui-hong Liang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
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Jian-ke Pan
Jian-ke Pan
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Ming-hui Luo
Ming-hui Luo
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Yan-hong Han
Yan-hong Han
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Jun Liu
Jun Liu
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
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Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China
The fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China
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Wei-yi Yang
Wei-yi Yang
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Introduction Osteoarthritis (OA) is a severe and painful joint disease that limits daily activities and reduces quality of life. OA is estimated to be the third leading cause of disability, affecting approximately 350 million people worldwide
Xiaofeng Deng
Xiaofeng Deng
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Haoran Xu
Haoran Xu
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Xiaoxia Hao
Xiaoxia Hao
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Jiawei Liu
Jiawei Liu
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Xingru Shang
Xingru Shang
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Tao Xu
Tao Xu
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Introduction The main pathological changes of osteoarthritis (OA) are related to cartilage degeneration, subchondral bone thickening, synovitis, and structural lesions of the joint capsules, ligaments, and associated muscles ( 1 , 2 ). The
Julien Favre
Julien Favre
Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
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Brigitte M. Jolles
Brigitte M. Jolles
Swiss BioMotion Laboratory, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
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Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
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Introduction Osteoarthritis (OA), the most common type of arthritis, is a disease causing pain, deformity, and dysfunction of the joints. This condition affects a constantly increasing portion of the population, inducing serious socio
Mario Herrera-Pérez
Mario Herrera-Pérez
Foot and Ankle Unit, Orthopaedic Department, Hospital Universitario de Canarias, Tenerife, Spain
Department of Surgery, Universidad de La Laguna, Tenerife, Spain
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Department of Surgery, Universidad de La Laguna, Tenerife, Spain
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Victor Valderrabano
Victor Valderrabano
Foot and Ankle Unit, Orthopaedic Department, Schmerzklinik, Basel, Switzerland
University of Basel, Basel, Switzerland
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University of Basel, Basel, Switzerland
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Alexandre L Godoy-Santos
Alexandre L Godoy-Santos
Orthopaedic Department, Hospital Israelita, Sao Paulo, Brazil
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César de César Netto
César de César Netto
Director of the UIOWA Orthopedic Functional Imaging Research Laboratory (OFIRL), Iowa, USA
Department of Orthopedic and Rehabilitation, University of Iowa, Iowa, USA
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Department of Orthopedic and Rehabilitation, University of Iowa, Iowa, USA
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David González-Martín
David González-Martín
Foot and Ankle Unit, Orthopaedic Department, Hospital Universitario de Canarias, Tenerife, Spain
Department of Surgery, Universidad de La Laguna, Tenerife, Spain
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Department of Surgery, Universidad de La Laguna, Tenerife, Spain
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Sergio Tejero
Sergio Tejero
Foot and Ankle Unit, Hospital Universitario Virgen del Rocío, Sevilla, Spain
Department of Surgery, Universidad de Sevilla, Sevilla, Spain
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Department of Surgery, Universidad de Sevilla, Sevilla, Spain
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Introduction Ankle osteoarthritis (OA) is a chronic disease affecting approximately 1% of the world population, with an estimated incidence of 30 cases per 100 000 inhabitants, and corresponds to between 2 and 4% of all patients with general
Myles C Murphy
Myles C Murphy
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
School of Health Sciences and Physiotherapy, The University of Notre Dame Australia, Fremantle, Western Australia, Australia
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School of Health Sciences and Physiotherapy, The University of Notre Dame Australia, Fremantle, Western Australia, Australia
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Christopher Latella
Christopher Latella
School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Ebonie K Rio
Ebonie K Rio
La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia
Australian Ballet, Southbank, Victoria, Australia
Victorian Institute of Sport, Albert Park Victoria, Australia
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Australian Ballet, Southbank, Victoria, Australia
Victorian Institute of Sport, Albert Park Victoria, Australia
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Janet L Taylor
Janet L Taylor
School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Neurophysiology Research Laboratory, School of Medical and Health Sciences, Centre for Human Performance, Edith Cowan University, Joondalup, Western Australia, Australia
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Stephanie Martino
Stephanie Martino
Cubus Physio Zug, Zug, Switzerland
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Colin Sylvester
Colin Sylvester
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
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William Hale
William Hale
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
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Andrea B Mosler
Andrea B Mosler
Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia
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La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia
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Introduction Osteoarthritis (OA) is a leading cause of pain and disability globally ( 1 ). It results in substantial health expenditure in Australia, with over $3.5 billion being spent annually on OA burden ( 2 ). OA presents as pain and
Hamid Rahmatullah Bin Abd Razak
Hamid Rahmatullah Bin Abd Razak
Department of Bioengineering, Imperial College London, London, UK
Sengkang General Hospital, Singapore
Joint first authors
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Sengkang General Hospital, Singapore
Joint first authors
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Daniel Chew
Daniel Chew
Faculty of Medicine, Imperial College London, London, UK
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Joint first authors
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Zepur Kazezian
Zepur Kazezian
Department of Bioengineering, Imperial College London, London, UK
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Anthony M.J. Bull
Anthony M.J. Bull
Department of Bioengineering, Imperial College London, London, UK
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Introduction Osteoarthritis (OA) is a global disease with a variety of pathophysiological factors. 1 These factors can be mechanical, biological or a combination of both. Cardinal features of OA include loss of joint space and cartilage
Mara Meyer Günderoth
Mara Meyer Günderoth
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
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Alexandra Bannach-Brown
Alexandra Bannach-Brown
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, QUEST Center for Responsible Research, Berlin, Germany
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Tobias Winkler
Tobias Winkler
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
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Johannes Keller
Johannes Keller
Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Robert Karl Zahn
Robert Karl Zahn
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
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Tazio Maleitzke
Tazio Maleitzke
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Musculoskeletal Surgery, Berlin, Germany
Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, Berlin, Germany
Trauma Orthopaedic Research Copenhagen Hvidovre (TORCH), Department of Orthopaedic Surgery, Copenhagen University Hospital – Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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Introduction Rheumatoid arthritis (RA) and osteoarthritis (OA) are the most common forms of arthritis and affect large parts of the global population. While both diseases share some phenotypical similarities (joint swelling and stiffness
Tommaso Bonanzinga
Tommaso Bonanzinga
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Pietro Conte
Pietro Conte
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Giuseppe Anzillotti
Giuseppe Anzillotti
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Vincenzo Longobardi
Vincenzo Longobardi
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Elizaveta Kon
Elizaveta Kon
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia
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Department of Traumatology, Orthopaedics and Disaster Surgery, Moscow, Russia
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Maria Rescigno
Maria Rescigno
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Maurilio Marcacci
Maurilio Marcacci
IRCCS Humanitas Research Hospital, via Manzoni, Rozzano, Milan, Italy
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, Pieve Emanuele, Milan, Italy
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Introduction Osteoarthritis (OA), most commonly developing in the knee joint, is the main cause of disability in older adults and is characterized by pain, loss of function, and decreased quality of life (QoL). Nowadays, an estimated 240
Alessandro Bensa
Alessandro Bensa
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Alessandro Sangiorgio
Alessandro Sangiorgio
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Angelo Boffa
Angelo Boffa
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Manuela Salerno
Manuela Salerno
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Giacomo Moraca
Giacomo Moraca
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
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Giuseppe Filardo
Giuseppe Filardo
Service of Orthopaedics and Traumatology, Department of Surgery, EOC, Lugano, Switzerland
Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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Applied and Translational Research (ATR) Center, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Università della Svizzera Italiana, Faculty of Biomedical Sciences, Lugano, Switzerland
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Introduction Knee osteoarthritis (OA) is one of the most common orthopedic diseases and represents a major cause of knee pain and disability in older adults ( 1 , 2 ). The prevalence of this degenerative condition is currently rising, with a
Huub H. de Klerk
Huub H. de Klerk
Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands
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Chantal L. Welsink
Chantal L. Welsink
Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands
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Anne J. Spaans
Anne J. Spaans
Department of Orthopaedic Surgery, St Maartenskliniek, Nijmegen/Boxmeer, The Netherlands
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Lukas P. E. Verweij
Lukas P. E. Verweij
Department of Orthopaedic Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Movement Sciences (AMS), Academic Center for Evidence-Based Sports Medicine (ACES), Amsterdam, The Netherlands
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Michel P. J. van den Bekerom
Michel P. J. van den Bekerom
Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands
Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
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Introduction Degenerative joint disease of the elbow is less common compared to the hip and knee. The prevalence of primary elbow osteoarthritis (OA) is 2–3%. 1 , 2 OA of the elbow can cause severe disabling symptoms of pain, locking
