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Andrew J Harrison Bioventus International, Taurusavenue, Hoofddorp, Netherlands

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Michael R Redler Connecticut Orthopaedics, Department of Orthopaedics, University of Virginia, Frank H. Netter School of Medicine, Quinnipiac University, USA

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David M Taylor Leeds General Infirmary, Leeds, UK

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Ansar Mahmood Department Trauma & Orthopaedic Surgery, Queen Elizabeth Hospital, Birmingham, UK

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John T Jones Statistician - Raleigh, NC

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Yukihiro Arai Department of Orthopaedic Surgery, Teikyo University School of Medicine

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Yoshinobu Watanabe Department of Orthopaedic Surgery, Teikyo University School of Medicine

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ultrasound (LIPUS) has been used to accelerate the process of fracture repair in humans since it was first reported in 1983 by Xavier and Duarte ( 9 ). In 1994, it was approved in the United States for accelerated healing of certain fresh fractures. By 2000

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Mustafa S. Rashid Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK

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Yves Tourné Institut Grenoblois de Chirurgie du Pied, Echirolles, France

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Kar H. Teoh Princess Alexandra Hospital, Harlow, UK

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union may lag behind clinical union in some cases. 5 One method that has been used to achieve union of fractures, osteotomies and fusion, is the application of low intensity pulsed ultrasound (LIPUS) therapy ( Table 1 ). 6 The increasing use of

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Felix Christoph Finger BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Steffen Schröter Diakonie Klinikum Jung-Stilling GmbH, Department of Trauma and Reconstructive Surgery, Siegen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany

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Christoph Ihle BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Moritz Herbst BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Tina Histing BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany

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Marc-Daniel Ahrend BG Klinik Tübingen, Department of Traumatology and Reconstructive Surgery, Eberhard Karls University of Tübingen, Tübingen, Germany
Osteotomie Komitee der Deutschen Knie Gesellschaft (DKG), Munich, Germany
AO Research Institute Davos, Davos, Switzerland

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study on 136 knees that low-intensity pulsed ultrasound (LIPUS) does not promote bone healing after opening HTO ( 52 ). The study found no significant differences in bone consolidation of the osteotomy gap at 6 weeks, as well as 3, 6 and 12 months

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Morten Schultz Larsen Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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Hagen Schmal Department of Orthopaedics and Traumatology, Odense University Hospital, Denmark

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(LIPUS) 57 and bone marrow aspirate concentrate 58 has been reported in small retrospective series and case control series, but evidence is still too limited to conclude any beneficial effect. Conclusions Atypical femoral fractures (AFFs

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Paul L Rodham Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Vasileios P Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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Nikolaos K Kanakaris Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland
Department of Trauma & Orthopaedics, University of Leeds, Leeds, United Kingdom of Great Britain and Northern Ireland

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Peter V Giannoudis Academic Department of Trauma & Orthopaedics, Leeds General Infirmary, Leeds, United Kingdom of Great Britain and Northern Ireland

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-operative techniques to stimulate the biology of non-healing fractures, particularly in comorbid patients who are at high risk from an anaesthetic point of view. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive technique that works through stimulating

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Elena Gálvez-Sirvent Department of Orthopaedic Surgery, ‘Infanta Elena’ University Hospital, Valdemoro, Madrid, Spain

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Aitor Ibarzábal-Gil Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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E. Carlos Rodríguez-Merchán Department of Orthopaedic Surgery, ‘La Paz’ University Hospital-IdiPaz, Madrid, Spain

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reintervention. 36 Non-invasive methods have been proposed to promote fracture healing, such as electrical stimulation in the form of pulsed electromagnetic fields (PEMFs), extracorporeal shock waves (ESWs) and low-intensity pulsed ultrasound (LIPUS

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Akintunde George Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Marianne Ellis Centre for Integrated Bioprocessing Research, Department of Chemical Engineering, University of Bath, Bath, UK

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Harinderjit Singh Gill Department of Mechanical Engineering, University of Bath, Bath, UK

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developed to enhance fracture healing: pulsed electromagnetic fields (PEMFs) and low intensity impulse ultrasounds (LIPUS), of which most studies confirm the beneficial effects. Factors which inhibit osseointegration include: excessive implant mobility and

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George D Chloros Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK
Orthopaedic Surgery Working Group, Society of Junior Doctors, Athens, Greece

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Christos D Kakos Orthopaedic Surgery Working Group, Society of Junior Doctors, Athens, Greece

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Ioannis K Tastsidis Orthopaedic Surgery Working Group, Society of Junior Doctors, Athens, Greece
University of Patras, School of Medicine, Patras, Greece

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Vasileios P Giannoudis Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK

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Michalis Panteli Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK

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Peter V Giannoudis Academic Department of Trauma and Orthopaedics, School of Medicine, University of Leeds, Leeds, UK
NIHR Leeds Biomedical Research Center, Chapel Allerton Hospital, Leeds, UK

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-019-0213-5 ) 120 Nolte P Anderson R Strauss E Wang Z Hu L Xu Z Steen RG . Heal rate of metatarsal fractures: a propensity-matching study of patients treated with low-intensity pulsed ultrasound (LIPUS) vs. surgical and other treatments . Injury 2016

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